A5101939003- Curcumin's Biomedical Applications
- Natural product bioactivities and synthesis
- Pharmacological Effects of Medicinal Plants
- Synthesis and biological activity
- Synthesis of Organic Compounds
- Biofuel production and bioconversion
- Endoplasmic Reticulum Stress and Disease
- Genomics, phytochemicals, and oxidative stress
- Enzyme Production and Characterization
- Analytical Chemistry and Sensors
- Advanced Chemical Sensor Technologies
- Electrochemical sensors and biosensors
- Crystal structures of chemical compounds
- Advanced Computational Techniques and Applications
- Gas Sensing Nanomaterials and Sensors
- Biochemical effects in animals
- Fungal Biology and Applications
- Microbial Natural Products and Biosynthesis
- Synthesis and Biological Evaluation
- Proteoglycans and glycosaminoglycans research
- Bioactive Compounds and Antitumor Agents
- Alkaloids: synthesis and pharmacology
- Sphingolipid Metabolism and Signaling
- Image Processing and 3D Reconstruction
- Advanced Graph Neural Networks
Huanggang Normal University
2022-2024
University of Electronic Science and Technology of China
2023
Hubei University
2022
Nanjing University of Science and Technology
2008-2019
Wenzhou Medical University
2016
Xuzhou University of Technology
2007
Beijing Institute of Technology
1992-2002
Major anti-inflammatory agents, steroids and cyclooxygenase, were proved to have serious side effects. Here, a series of chalcone derivatives synthesized screened for activities. QSAR study revealed that the presence electron-withdrawing groups in B-ring electron-donating A-ring chalcones was important inhibition LPS-induced IL-6 expression. Further, compounds 22, 23, 26, 40, 47 inhibited TNF-α release dose-dependent manner decreased TNF-α, IL-1β, IL-6, IL-12, COX-2 mRNA production....
BACKGROUND AND PURPOSE Inflammation is involved in the development and/or progression of many diseases including diabetic complications. Investigations on novel anti‐inflammatory agents may offer new approaches for prevention nephropathy. Our previous bioscreening synthetic analogues curcumin revealed C66 as a compound against LPS challenge macrophages. In this study, we hypothesized that affects high glucose (HG)‐induced inflammation profiles vitro and vivo then prevents renal injury rats...
Gastric cancer (GC) is one of the leading causes mortality in world. In addressing need treatments for relapsed disease, we report identification an existing U.S. Food and Drug Administration-approved small-molecule drug to repurpose GC treatment. Auranofin (AF), clinically used treat rheumatic arthritis, but it exhibited preclinical efficacy cells. By increasing intracellular reactive oxygen species (ROS) levels, AF induces a lethal endoplasmic reticulum stress response mitochondrial...
Sepsis, an acute inflammatory disease, remains the most common cause of death in intensive care units. A series benzimidazole and imidazopyridine derivatives were synthesized screened for anti-inflammatory activities, showed excellent inhibition expression cytokines LPS-stimulated macrophages. Compounds X10, X12, X13, X14, X15 inhibited TNF-α IL-6 release a dose-dependent manner, X12 no cytotoxicity hepatic cells. Furthermore, exhibited significant protection against LPS-induced septic mouse...
The synthesis of three series curcumin analogues with mono-carbonyl is described. Their in vitro anti-bacterial activities against seven Gram-positive and Gram-negative bacteria were tested the effect substituents on aryl ring space structure linking strain discussed. It was observed that part derivatives displayed significant activity when compared most them exhibited ampicillin-resisted Enterobacter cloacae. Compounds A12, B09, B13, B14 C09 show remarkable antibacterial vitro. result...
Curcumin (diferuloylmethane) is an orange-yellow compound from turmeric (Curcuma longa), a spice found in curry powder. Traditionally known for its anti-inflammatory effects, curcumin has established itself the last two decades to be potent immunomodulatory agent that can regulate activation of variety immunocytes and expression inflammatory factors. Considering beta-diketone moiety may result instability poor metabolic property, we previously designed series mono-carbonyl analogues with...
// Peng Zou 1,2,* , Yiqun Xia 3,* Weiqian Chen 2 Xi Shilong Ying Zhiguo Feng Tongke Qingqing Ye Zhe Wang Chenyu Qiu Shulin Yang 1 and Guang Liang School of Environmental Biological Engineering, Nanjing University Science Technology, Nanjing, Jiangsu, China Chemical Biology Research Center, Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 3 Department Digestive Diseases, The First Affiliated Hospital * These authors have contributed equally to this work Correspondence...
Pyocyanin, a major virulence factor produced by Pseudomonas aeruginosa, displays redox activity and damaging effects on mammalian cells. In this study, we investigated the of pyocyanin proliferation HepG2 tumour Interestingly, significantly inhibited cell triggered production large amounts reactive oxygen species (ROS), thereby upregulating superoxide dismutase (SOD) catalase (CAT). Additionally, treatment depleted reduced glutathione (GSH) decreased GSH/oxidized GSH (GSSG) ratio. These...
Gastric cancer is one of the leading causes mortality in world. Curcumin a natural product with multiple pharmacological activities, while its clinical application has been limited by poor chemical stability. We have previously designed series curcumin derivatives high stability and anticancer potentials. The present study aims to identify anti‐cancer effects mechanisms WZ26, an analog curcumin, gastric cells. In vitro, WZ26 showed higher much stronger anti‐proliferative than accompanied...
Curcumin has been reported to possess multiple bioactivities, such as antioxidant, anticancer, and anti-inflammatory properties, however the clinical application of curcumin significantly limited by its instability poor metabolism. Modification led discovery development lots novel therapeutic candidates. In recent years acute chronic inflammation focus numerous studies in various diseases. Here, we synthesized a series asymmetrical analogs with high vitro chemical stability, their activity...
Abstract Endoplasmic reticulum (ER) stress‐induced cancer cell apoptosis has become a novel signaling target for the development of therapeutic drugs treatment. Curcumin, dietary phytochemical, exhibits growth‐suppressive activity against cells via multitarget mechanisms. However, low stability and poor pharmacokinetics significantly limit its clinical applications. Thus, we designed synthesized monocarbonyl analog curcumin, 1,5‐bis(2‐methoxyphenyl) penta‐1,4‐dien‐3‐one (B63). This compound...
Inflammation is a hallmark of many diseases. Although steroids and cyclooxygenase inhibitors are main anti-inflammatory therapeutical agents, they may cause serious side effects. Therefore, developing non-steroid agents urgently needed. A novel hydrosoluble compound, C12 (2,6-bis(4-(3-(dimethylamino)-propoxy)benzylidene)cyclohexanone), has been designed synthesized as an agent in our previous study. In the present study, we investigated whether can affect inflammatory processes vitro vivo....
Using curcumol that was extracted from the volatile oil of Rhizoma Curcumae as raw material, its derivatives were synthesized and purified. The structures these compounds confirmed by 1H, 13C NMR, mass spectral data. test evaluated for their in vitro anti-tumor activity against gastric cancer cell lines SGC-7901 lung carcinoma line H460 methyl thiazolyl tetrazolium chromatometry. Distinct structure–activity relationships also revealed inhibiting proliferation. Presence electron-withdrawing...
UDP-glucose dehydrogenase (UGDH) catalyzes the conversion of to UDP-glucuronic acid by NAD + -dependent two-fold oxidation.Despite extensive investigation into catalytic mechanism UGDH, previously proposed mechanisms regarding first-step oxidation are somewhat controversial and inconsistent with some biochemical evidence, which instead supports a involving an bimolecular nucleophilic substitution (S N 2) reaction.To verify this speculation, essential Cys residue Streptococcus zooepidemicus...