A5100770548- Curcumin's Biomedical Applications
- Wound Healing and Treatments
- Genomics, phytochemicals, and oxidative stress
- Inflammasome and immune disorders
- Synthesis of Organic Compounds
- Heme Oxygenase-1 and Carbon Monoxide
- Advanced Glycation End Products research
- Biochemical effects in animals
- Antimicrobial Peptides and Activities
- Natural product bioactivities and synthesis
- Plant-derived Lignans Synthesis and Bioactivity
- Plant Molecular Biology Research
- Tumors and Oncological Cases
- Advancements in Transdermal Drug Delivery
- Protein Tyrosine Phosphatases
- Medical and Biological Ozone Research
- Dialysis and Renal Disease Management
- Chemokine receptors and signaling
- Ion Channels and Receptors
- Chronic Kidney Disease and Diabetes
- Fibroblast Growth Factor Research
- Smart Grid and Power Systems
- Atherosclerosis and Cardiovascular Diseases
- Chemotherapy-induced organ toxicity mitigation
- Sepsis Diagnosis and Treatment
Baylor College of Medicine
2023
Guizhou University
2022
Wenzhou Medical University
2012-2022
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2022
Shanxi Medical University
2022
CHN Energy (China)
2022
Hebei University of Technology
2017
Xinyang Normal University
2005-2016
Anhui Agricultural University
2009-2014
People's Bank of China
2013
BACKGROUND AND PURPOSE Inflammation is involved in the development and/or progression of many diseases including diabetic complications. Investigations on novel anti‐inflammatory agents may offer new approaches for prevention nephropathy. Our previous bioscreening synthetic analogues curcumin revealed C66 as a compound against LPS challenge macrophages. In this study, we hypothesized that affects high glucose (HG)‐induced inflammation profiles vitro and vivo then prevents renal injury rats...
Sepsis, an acute inflammatory disease, remains the most common cause of death in intensive care units. A series benzimidazole and imidazopyridine derivatives were synthesized screened for anti-inflammatory activities, showed excellent inhibition expression cytokines LPS-stimulated macrophages. Compounds X10, X12, X13, X14, X15 inhibited TNF-α IL-6 release a dose-dependent manner, X12 no cytotoxicity hepatic cells. Furthermore, exhibited significant protection against LPS-induced septic mouse...
// Peng Zou 1,2,* , Yiqun Xia 3,* Weiqian Chen 2 Xi Shilong Ying Zhiguo Feng Tongke Qingqing Ye Zhe Wang Chenyu Qiu Shulin Yang 1 and Guang Liang School of Environmental Biological Engineering, Nanjing University Science Technology, Nanjing, Jiangsu, China Chemical Biology Research Center, Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 3 Department Digestive Diseases, The First Affiliated Hospital * These authors have contributed equally to this work Correspondence...
There is a high incidence of acute and chronic skin defects caused by various reasons in clinically practice. The repair functional reconstruction have become major clinical problem, which needs to be solved urgently. Previous studies shown that fibroblast growth factor 10 (FGF10) plays role promoting the proliferation, migration, differentiation epithelial cells. However, little known about effect FGF10 on recovery process after damage. In this study, we found expression endogenous was...
Clock genes are considered to be the molecular core of biological clock in vertebrates and they directly involved regulation daily rhythms vertebrate tissues such as skeletal muscles. Fish myotomes composed anatomically segregated fast slow muscle fibers that possess different metabolic contractile properties. To date, there is no report on characterization circadian system components muscles fish. In present study, (clock, arntl1/2, cry1/2/3, cry-dash, npas2, nr1d1/2, per1/2/3, rorα tim...
// Xiaoou Shan 1, 2, * , Yali Zhang Hongjin Chen Lili Dong 3 Beibei Wu 2 Tingting Xu Jie Hu 1 Zhiguo Liu Wei Wang 4 Liqin Feng Guang Liang Chemical Biology Research Center at School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China The Second Affiliated Hospital and Yuying Children's Zhengzhou, Henan, Pharmacy, Qingdao Qingdao, Shandong, These authors contributed equally to this work Correspondence to: Liang, email: wzmcliangguang@163.com Feng, zhiguof@126.com...
Here, we explored the correlation between gut microbiota and bone health effects of high-fructose corn syrup (HFCS) on both. Sixteen 3-week-old male C57BL/6J mice were randomly divided into two groups given purified water (control group) or 30% HFCS in (HFCS for 16 weeks. The assessed via enzyme-linked immunosorbent assays, histopathological assays colon bone, 16S rDNA sequence analysis microbiota. serum group had lower levels alkaline phosphatase (BALP), Gla protein (BGP), insulin-like...
Keratinocyte growth factor 1 (KGF1) is a that promotes epidermal cell proliferation, migration, differentiation, and wound repair. It expressed at low levels in form of inclusion body E. coli. In order to increase its expression activity, we produced tobacco plants expressing KGF1 via Agrobacterium-mediated transformation using potato virus X (PVX) -based vector (pgR107). The contained the sequence encoding gene fused with green florescence protein. recombinant plasmid was introduced into...
Abstract: Sepsis remains a leading cause of death worldwide. Despite years extensive research, effective drugs to treat sepsis in the clinic are lacking. In this study, we found novel imidazopyridine derivative, X22, which has powerful anti-inflammatory activity. X22 dose-dependently inhibited lipopolysaccharide (LPS)-induced proinflammatory cytokine production mouse primary peritoneal macrophages and RAW 264.7 macrophages. also downregulated LPS-induced gene expression vitro. vivo,...
Autophagy and endoplasmic reticulum stress (ER stress) are important in numerous pathological processes traumatic brain injury (TBI). Growing evidence has indicated that pyroptosis-associated inflammasome is involved the pathogenesis of TBI. Platelet derived growth factor (PDGF) been reported to be as a potential therapeutic drug for neurological diseases. However, roles PDGF, autophagy ER pyroptosis have not elucidated This study investigated after TBI at different time points. We found...
SK66-his, a novel glycine-rich peptide derived from the CG13551 gene of Drosophila, was directly expressed in Escherichia coli with help glucose effect lac repressor and efficiently purified high yield (10.063 mg/l). It showed significant activity against Gram-positive bacteria. We determined MIC value 9 μg ml−1 Bacillus thuringiensis.
Tip clearance between the runner blade tip and shroud in a Kaplan turbine is inevitable, leakage flow (TLF) vortex (TLV) induced by have considerable effect on behaviors. To reveal of characteristics, based Reynolds time-averaged Navier-Stokes (N-S) equation shear stress transfer (SST) k-ω turbulence model, three-dimensional simulated using ANSYS CFX. Meanwhile, laws are emphatically analyzed summarized. Results show with increase clearance, negative pressure region suction side (SS) middle,...
Daintain/AIF-1 was identified from injured rat carotid arteries and porcine intestine in the mid 1990s. It is involved autoimmune disorders, chronic rejection of allografts, gliomas, breast cancer. Since it convenient economical to obtain such a peptide biologically, this study, we describe expression, purification, characterization recombinant human daintain/AIF-1 (rhdaintain/AIF-1). The backbone vector pET32a, high-level expression plasmid, used construct pET32a-daintain/AIF-1 plasmid for...
Recent data indicated that aging accelerated glomerular fibrin deposition induced by lipopolysaccharide (LPS) in mice. Our hypothesis was may exacerbate inflammatory responses deposition. Both young and aged rats with LPS were treated tranexamic acid (TA) TA plus urokinase (UK). Infiltrating cells expressions of monocyte chemoattractant protein 1, intercellular adhesion molecule vascular endothelial-cadherin markedly upregulated the LPS+TA group compared group. Reduction LPS+TA+UK associated...
The inhibitory impacts of spikes on LFP theta rhythms(4-8Hz) are investigated around sporadic spikes(SSs) based intracerebral EEG 4 REM sleep patients with temporal lobe epilepsy(TLE) under the pre-surgical monitoring. Sequential interictal in both genesis area and extended propagation pathway collected, that, SSs only anterior hippocampus(aH)(possible Entorhinal cortex(EC)), EC(possible aH), aH EC synchronously. Instantaneous power was estimated by using Gabor wavelet transform, level...