A5100684869- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- RNA Research and Splicing
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Estrogen and related hormone effects
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- HER2/EGFR in Cancer Research
- Glutathione Transferases and Polymorphisms
- NF-κB Signaling Pathways
- Sphingolipid Metabolism and Signaling
- Endoplasmic Reticulum Stress and Disease
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Breast Cancer Treatment Studies
- Dermatological and Skeletal Disorders
- Cancer Research and Treatments
- Ubiquitin and proteasome pathways
- Fibroblast Growth Factor Research
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Cancer Mechanisms and Therapy
- Skin and Cellular Biology Research
Nanjing Medical University
2020-2025
South China Agricultural University
2025
The Ohio State University
2004-2025
Shanghai Jiao Tong University
2021-2025
International Peace Maternity & Child Health Hospital
2025
Shanghai Children's Medical Center
2025
Guiyang Medical University
2025
Third Affiliated Hospital of Southern Medical University
2025
East China University of Science and Technology
2024
Tianjin Medical University
2017-2024
Necroptotic factors are generally assumed to play a positive role in tumor therapy by eliminating damaged cells. Here we show that, contrary expectation, necroptotic RIPK1, RIPK3, and MLKL promote growth. We demonstrate that genetic knockout of genes or cancer cells significantly attenuated their abilities grow an anchorage-independent manner. In addition, they exhibited enhanced radiosensitivity. The also showed greatly reduced ability form tumors mice. Moreover, necrosulfonamide (NSA),...
Abstract Escherichia coli MLB (MG1655 Δ pflB ldhA ), which can hardly grow on glucose with little succinate accumulation under anaerobic conditions. Two-stage fermentation is a in the first stage used for cell growth and second product production. The ability of consumption production conditions be improved significantly by using acetate as solo carbon source aerobic condition during two-stage fermentation. Then, adaptive laboratory evolution (ALE) growing was applied here. We assumed that...
A simple and ultrasensitive microRNA (miRNA) electrochemical biosensor employing multiwalled carbon nanotube (MWCNT)-polyamidoamine (PAMAM) dendrimer methylene blue (MB) redox indicator is reported in this work. The assay utilizes a glass (GC) electrode modified with MWCNT-PAMAM, on which the oligonucleotide capture probes are immobilized. detection of miRNAs completed by measuring reduction signal change MB before after probe hybridization target miRNA (miRNA24 used as model case)....
Biocompatibility, targeting, and clearance are key challenges in the design of new MRI contrast agents. Herein, we report on a tumor-targeting, gadolinium biomineralized human transferrin (Tf) protein-based nanoparticle (Gd@Tf NP) for use. As compared to conventionally used chelates, resultant Gd@Tf NPs possess outstanding chemical stability exhibited superior longitudinal relaxation. More importantly, our MR images show that indeed retained natural tumor targeting ability subsequent...
Personalized antitumor immunotherapy utilizing neoantigen vaccines holds great promise. However, the limited immunogenicity of existing recognized neoantigens and inadequate stimulation immune responses by conventional adjuvants pose significant challenges. To address these limitations, we developed a nanovaccine that combines BCG bacterial cell wall skeleton (BCG-CWS) based nanoscale adjuvant (BCNA) with peptide (M27 M30). This integrated approach provides an efficient translational...
Diabetic nephropathy is characterized by accumulation of glomerular extracellular matrix proteins, such as fibronectin (FN). Here, we investigated whether sphingosine kinase (SphK)1 pathway responsible for the elevated FN expression in diabetic nephropathy. The SphK1 and were examined streptozotocin-induced rat kidney mesangial cells (GMC) exposed to high glucose (HG). up-regulation was concomitant with activation reflected an increase activity 1-phosphate (S1P) production both HG-treated...
Ubiquitination is a reversible process of posttranslational protein modification through the action family deubiquitylating enzymes which contain ubiquitin-specific protease 9x (USP9X). Recent evidence indicates that USP9X involved in progression various human cancers. The aim was to detect expression from normal epithelium invasive esophageal squamous cell cancer (ESCC) and evaluate relevance tumor prognosis.In this study, immunohistochemical analysis performed on tissues constructed ESCC...
The accumulation of glomerular extracellular matrix (ECM) is one the critical pathological characteristics diabetic renal fibrosis. Fibronectin (FN) an important constituent ECM. Our previous studies indicate that activation sphingosine kinase 1 (SphK1)-sphingosine 1- phosphate (S1P) signaling pathway plays a key regulatory role in FN production mesangial cells (GMCs) under condition. Among five S1P receptors, S1P2 receptor most abundant. Berberine (BBR) treatment also effectively inhibits...
MicroRNAs refer to small RNA molecules that destroy the messenger by binding on them inhibiting production of protein. However, role miR-155 in uveal melanoma metastasis remains largely unknown. In this study, we found was upregulated both cells and tissues. Transfection mimic into led an increase cell growth invasion; contrast, inhibition resulted opposite effects. Also, identified Nedd4-family interacting protein 1 as a direct target miR-155, expression inhibited miR-155. Furthermore,...
Carbon nanotubes (CNTs) labeled with aptamer and horseradish peroxidase (HRP) were used as a probe to amplify the impedimetric sensing of aptamer-protein (with thrombin model) interaction. The HRP-biocatalyzed oxidation 3,3-diaminobenzidine (DAB) in presence H2O2 postelectropolymerization insoluble precipitates produced on electrode supports signal amplification route for process. Thrombin was sensed by 1 immobilized glassy carbon electrode. multiwalled CNT-aptamer 2-HRP linked 1-thrombin...
Abstract Lung cancer is the leading cause of deaths in United States, surpassing breast as primary cancer-related mortality women. The goal present study was to identify early molecular changes lung induced by exposure tobacco smoke and thus potential targets for chemoprevention. Female A/J mice were exposed either or HEPA-filtered air via a whole-body chamber (6 h/d, 5 d/wk 3, 8, 20 weeks). Gene expression profiles tissue from control smoke-exposed animals established using 15K cDNA...
Breast cancer is the most common malignancy in women, and neoadjuvant chemotherapy has been recommended to patients with locally advanced breast as initial treatments. Long non-coding RNA (lncRNA) MEG3, an identified tumor suppressor, implicated development of various cancers. However, there no data evaluate effect MEG3 polymorphisms on treatment cancer. Genotyping was performed using Nanodispenser Spectro CHIP chip spotting Mass ARRAY Compact System. Univariate multivariate logistic...
Triple negative breast cancer (TNBC) is a subtype of with poor prognosis and lack effective treatment target. Here we screened differentially expressed lncRNAs through bioinformatics analysis identified CARMN as downregulated lncRNA which lowest in TNBC. We aimed to identify the potential role molecular mechanisms TNBC.Predictive value was explored cohorts. TNBC cell lines overexpression or silence were used for vitro vivo experiments. RNA-seq overexpressed cells performed exploring...
Cognitive impairment (CI) is a prevalent and significant health concern among patients undergoing maintenance hemodialysis (MHD). Recent studies have highlighted the growing interest in dynapenic abdominal obesity (DAO), which combines both low muscle strength excess fat. Despite increasing recognition of DAO, its association with CI MHD remains uncertain. The objective this study was to investigate relationship between DAO patients. We conducted multicenter, cross-sectional twenty dialysis...
Lumbar intervertebral disc degeneration (LIDD) serves as a principal contributor to low back pain, condition that poses considerable global health and socioeconomic challenges. Recent studies have emphasized the significance of ferroptosis, an iron-dependent mechanism programmed cell death, in nucleus pulposus cells (NPCs). This research examines protective role 1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃], active metabolite Vitamin D (VD), LIDD through modulation ferroptosis. The results indicate...
ABSTRACT This study aimed to elucidate the roles of junctional adhesion molecule 2 (JAM‐2), collagen I and matrix metalloproteinase (MMP‐2) in pathogenesis pelvic organ prolapse (POP) explore their potential as diagnostic markers. We examined 82 POP patients 64 controls using enzyme‐linked immunosorbent assay (ELISA) quantitative Polymerase Chain Reaction (qPCR) analyse protein gene expression levels JAM‐2, Collagen MMP‐2. Receiver operating characteristic (ROC) analysis evaluated efficacy,...