A5104753181- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Monoclonal and Polyclonal Antibodies Research
- Trace Elements in Health
- Atherosclerosis and Cardiovascular Diseases
- Circadian rhythm and melatonin
- T-cell and B-cell Immunology
- Glutathione Transferases and Polymorphisms
- Cancer Cells and Metastasis
- Nutrition, Genetics, and Disease
- Immunotherapy and Immune Responses
- Adipokines, Inflammation, and Metabolic Diseases
- Fatty Acid Research and Health
- Exercise and Physiological Responses
- Virus-based gene therapy research
- Diet and metabolism studies
- Cancer, Hypoxia, and Metabolism
- Dietary Effects on Health
- Immune Response and Inflammation
- Child Nutrition and Feeding Issues
- Cancer-related molecular mechanisms research
- HER2/EGFR in Cancer Research
- Lymphoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Folate and B Vitamins Research
Faculdade de Medicina de São José do Rio Preto
2014-2025
Florida International University
2025
Hospital Israelita Albert Einstein
2024
Faculdade de Medicina do ABC
2024
The University of Texas Health Science Center at San Antonio
1989-2009
Audie L. Murphy Memorial VA Hospital
2009
Taichung Veterans General Hospital
1991
Murphy Oil Corporation (United States)
1991
Memorial Sloan Kettering Cancer Center
1976-1985
Oklahoma Medical Research Foundation
1984
AKR mice were protected from lethal irradiation and established as long-lived chimeras by transplanting allogeneic C57BL/6 (B6) bone marrow that had been treated in vitro with anti-Thy-1 antiserum without complement. In these chimeras, which designated [B6 {arrow} AKR], virtually all the thymus spleen cells shown to be derived B6 donor; several immune functions studied follows: (a) The chimeric tolerant of histocompatibility antigens both donor recipient strain nearly fully reactive third...
After passage of spleen cells from nu/nu mice over a nylon wool column, concanavalin A-responsive can be detected in the presence 2-mercaptoethanol, and specific cytotoxic T lymphocytes generated without exposure to interleukin 2 (IL-2). The born parents nursed by mothers had significantly fewer Thy-1+ lesser capacity generate than did conventionally bred mice. Nonetheless, such were clearly present. IL-2 may act cause these post-thymic proliferate. Therefore, it seems inappropriate consider...
Abstract Three and one-half-week-old male inbred Fischer rats housed individually at 24 ± 1°C with Purina Chow water ad libitum were randomly assigned to six different rhythmometry chambers, each lighted daily for 12 hr darkened the following hr. The timing of these regimens differed from one chamber next by 4 (i.e., was illuminated 0600 1800, 1000 2200, etc.). Thus, completely light-dark synchronized animals sampled chambers any given clock time intended represent, in relation onset light...
NZB mice are extensively used throughout the world as a model system for studying autoimmune disease. Apparently associated with propensity to early development of hemolytic anemia, breeding capacity is defective; and life span these animals short. As part general effort improve in our colonies, comparison influence two commercial diets on was made. One diet provided low protein relatively high fat; other, somewhat higher lower fat content. Improved performance observed fed fat, intake. But,...
Head and neck cancer (HNC) is one of the most common types in world, characterized by resistance to conventional therapies an unfavorable prognosis due presence tumor stem cells (TSCs). TSCs are cell subpopulations with high potential for invasion, migration, metastasis, being responsible initiation dissemination cancer. This study aimed evaluate efficacy treatments cetuximab paclitaxel, alone combination, from oral cavity (SCC-28) hypopharynx (FADU) lines. In addition, influence gene...
Aspirin-like drugs (ALD) enhance T cell proliferation by suppressing PG production in monocytes. Normal human cells do not produce any eicosanoids. Therefore we studied whether ALD would affect purified directly. We found that enhanced the and IL-2 of absence This effect did depend on arachidonic acid metabolism as no lipoxygenase products only nonsuppressive levels cyclooxygenase were detected cultures. Several possible mechanisms ruled out including 1) mitogen binding, 2) induction...
The effect of dietary restriction on the expression retroviral envelope glycoprotein, gp70, and formation gp70-anti gp70 immune complexes was investigated in lupus-prone NZB x NZW F1 hybrid mice. Restricting total calorie intake from usual 20 to only 10 calories per day after weaning markedly reduced serum levels both free antibody-complexed prevented renal disease, increased life spans these reduction evident 2 wk feeding animals low-calorie diet, concentration remained virtually unchanged...
Antibodies against cellular antigens appear during aging in some strains of mice but not others. In susceptible strains, manifestations autoimmunity include development Coombs positive hemolytic anemia, circulating anti-DNA and anti-desoxynucleoprotein antibodies, LE cells, immunologically based renal cardiac lesions. Neonatal thymectomy may accelerate these autoimmune phenomena. The are prone to lose immune capacities (particularly cell-mediated responses) with aging. Thymectomy accelerates...
Abstract Effector cells mediating natural killer (NK) cell activity and antibody‐dependent cellular cytotoxicity (ADCC) have been receiving considerable interest recently as they may represent an additional defense mechanism against maglinancy. Spleen from normal young C3H (MTV+) female mice were found to relatively high activities toward RL 1 YAC‐1 tumor lines cell‐mediated chicken RBC SB targets. Serum inhibition of NK ADCC was either not demonstrable or only seen at low levels in the...
Sporadic colorectal cancer (SCRC) is the third most common worldwide and includes malignancies that occur in colon rectum.Age greater than 60 years, smoking, alcohol habits are some of risk factors for SCRC.Detoxification elimination carcinogens contained tobacco require metabolic activation mediated by enzymes metabolize xenobiotics (XME).Polymorphisms genes such as GSTP1 , GSTT1 GSTM1 encode involved XMEs may be related to important processes carcinogenesis.
Autoimmune-prone B/W mice, which are known to develop severe glomerulonephritis and vasculitis, also found arteritis proliferative fatty-proliferative lesions of the aorta its branches as well renal inflammatory lesions. High intake saturated fat in diet enhances development these atherosclerotic autoimmune significantly female whereas restriction dietary calories inhibits their development. Ad lib feeding laboratory chow, high fiber low fat, does not foster vascular but permit disease.