A5008798506- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Cytomegalovirus and herpesvirus research
- Neurogenesis and neuroplasticity mechanisms
- Helicobacter pylori-related gastroenterology studies
- Cancer-related Molecular Pathways
- Toxoplasma gondii Research Studies
- Circular RNAs in diseases
- Protein Degradation and Inhibitors
- Nerve injury and regeneration
- Neuroblastoma Research and Treatments
- Mycobacterium research and diagnosis
- Histone Deacetylase Inhibitors Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Veterinary medicine and infectious diseases
- Brain Metastases and Treatment
Faculdade de Medicina de São José do Rio Preto
2020-2025
Universidade Estadual Paulista (Unesp)
2022-2025
Head and neck cancer (HNC) is one of the most common types in world, characterized by resistance to conventional therapies an unfavorable prognosis due presence tumor stem cells (TSCs). TSCs are cell subpopulations with high potential for invasion, migration, metastasis, being responsible initiation dissemination cancer. This study aimed evaluate efficacy treatments cetuximab paclitaxel, alone combination, from oral cavity (SCC-28) hypopharynx (FADU) lines. In addition, influence gene...
Mutations and alterations in the expression of VEGFA, KRAS, NFE2L2 oncogenes play a key role cancer initiation progression. These genes are enrolled not only cell proliferation control, but also angiogenesis, drug resistance, metastasis, survival tumor cells. MicroRNAs (miRNAs) small, non-coding regulatory RNA molecules that can regulate post-transcriptional multiple target genes. We aimed to investigate if miRNAs hsa-miR-17-5p, hsa-miR-140-5p, hsa-miR-874-3p could interfere lines derived...
Toll-like receptor-2 (TLR2) is responsible for recognizing Helicobacter pylori (H. pylori) and activating the immune response. Polymorphisms in TLR2 may modulate gastric carcinogenesis.To evaluate whether 19216T/C (rs3804099) -196 to -174 ins/del (rs111200466) polymorphisms contribute carcinogenesis Brazilian population, determine influence of both H. infection on mRNA expression.DNA was extracted from 854 peripheral blood leukocyte or tissue samples [202 cancer (GC), 269 chronic gastritis...
Cancer biologists have focused on studying cancer stem cells (CSCs) because of their ability to self-renew and recapitulate tumor heterogeneity, which increases resistance chemotherapy is associated with relapse. Here, we used two approaches isolate CSCs: the first involved metabolic enzyme aldehyde dehydrogenase ALDH, second three cell surface markers CD44, CD117, CD133. ALDH showed a higher zinc finger E-box binding homeobox 1 (ZEB1) microRNA (miRNA) expression than CD44/CD117/133...