A5064383177- Toxoplasma gondii Research Studies
- Nutrition and Health in Aging
- Parasitic Infections and Diagnostics
- Healthcare Regulation
- Cytomegalovirus and herpesvirus research
- Child Nutrition and Feeding Issues
- Venomous Animal Envenomation and Studies
- Health, Nursing, Elderly Care
- Consumer Attitudes and Food Labeling
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Indigenous Health and Education
- Health, Education, and Aging
- Synthesis and Biological Evaluation
- Rabies epidemiology and control
- Science and Education Research
- Synthesis and bioactivity of alkaloids
- Physical Education and Gymnastics
- Iron Metabolism and Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Physical Education and Sports Studies
- Nutrition, Genetics, and Disease
- Palliative and Oncologic Care
- Obesity, Physical Activity, Diet
- Agricultural and Food Sciences
Universidade Federal de Uberlândia
2007-2025
Universidade Federal de Campina Grande
2018
Oslo University Hospital
2015
Congenital toxoplasmosis is represented by the transplacental passage of Toxoplasma gondii from mother to fetus. Our studies demonstrated that T. developed mechanisms evade host immune response, such as cyclooxygenase (COX)-2 and prostaglandin E2 (PGE2) induction, these mediators can be produced/stored in lipid droplets (LDs). The aim this study was evaluate role COX-2 LDs during infection human trophoblast cells villous explants. data inhibitors decreased replication villous. In BeWo cells,...
Toxoplasmosis is an alarming public health problem that affects more than one-third of the world's population. In our work, we investigated antiparasitic effects catalytically active [BpMP-I and Jararhagin (Jar)] inactive [Jararhagin-C (Jar-C)] snake venom metalloproteinases (SVMPs) in human HeLa cells. These toxins impaired parasite invasion intracellular growth, modulated IL-6, IL-8, MIF cytokines control cell susceptibility response against T. gondii. Furthermore, verified antiprotozoal...
The conventional treatment of congenital toxoplasmosis is mainly based on the combination sulfadiazine and pyrimethamine. However, therapy with these drugs associated severe side effects resistance, requiring study new therapeutic strategies. There are currently many studies natural products, including Copaifera oleoresin, showing actions against some pathogens, as Trypanosoma cruzi Leishmania . In present study, we investigated leaf hydroalcoholic extract oleoresin from multijuga Toxoplasma...
Abstract The combination of pyrimethamine and sulfadiazine is the standard care in cases congenital toxoplasmosis. However, therapy with these drugs associated severe sometimes life-threatening side effects. investigation phytotherapeutic alternatives to treat parasitic diseases without acute toxicity essential for advancement current therapeutic practices. present study investigates antiparasitic effects oleoresins from different species Copaifera genus against T. gondii . Oleoresins C....
Toxoplasma gondii is able to infect a wide range of vertebrates, including humans. Studies show that cyclooxygenase-2 (COX-2) modulator immune response in multiple types infection, such as Trypanosoma cruzi. However, the role COX-2 during T. infection still unclear. The aim this study was investigate by moderately or highly virulent strains Calomys callosus rodents and human THP-1 cells. C. were infected with 50 cysts (ME49), treated inhibitors (meloxicam celecoxib) evaluated check body...
Toxoplasma gondii is the etiologic agent of toxoplasmosis, a disease that affects about one-third human population. Most infected individuals are asymptomatic, but severe cases can occur such as in congenital transmission, which be aggravated with other pathogens, HIV-positive pregnant women. However, it unknown whether infection by Trypanosoma cruzi, Chagas disease, well one its proteins, P21, could aggravate T. infection.In this sense, we aimed to investigate impact cruzi and recombinant...
Growing concern about replacing fossil fuels with renewable energy sources, coupled society’s concerns environmental preservation, are the main reasons why governments have sought strategies for increased production and consumption of sustainable fuels. Radish (Raphanus sativus L.) belongs to group oilseeds Brassicaceae family, being widely cultivated in south central-west regions Brazil, physical chemical characteristics propitious biofuels. In this context, objective present work was...
P21 is a protein secreted by all forms of Trypanosoma cruzi ( T. ) with recognized biological activities determined in studies using the recombinant form protein. In our recent study, we found that ablation gene decreased Y strain axenic epimastigotes multiplication and increased intracellular replication amastigotes HeLa cells infected metacyclic trypomastigotes. present investigated effect vitro C2C12 cell lines tissue culture-derived trypomastigotes (TCT) wild-type knockout (TcP21 −/−...
Galectin-3 (Gal-3) is a β-galactoside-binding lectin expressed in cells of the placental microenvironment. This involved various biological processes, such as modulation immune system and control parasitic illness. Toxoplasma gondii infection can lead to congenital transmission cause miscarriages, prematurity fetal anomalies. However, little known about role Gal-3 T. study aimed unravel underlying mechanisms during infection. For this purpose, we promoted knockdown expression by using RNA...
BACKGROUND Leishmaniasis, a neglected disease caused by the parasite Leishmania, is treated with drugs associated high toxicity and limited efficacy, in addition to constant reports of emergence resistant parasites. In this context, snake serums emerge as good candidates since they are natural sources potential yield novel drugs. OBJECTIVES We aimed show antileishmanial effects γCdcPLI, phospholipase A2 inhibitor from Crotalus durissus collilineatus serum, against Leishmania (Leishmania)...