A5016122319- Toxoplasma gondii Research Studies
- Macrophage Migration Inhibitory Factor
- Parasitic Infections and Diagnostics
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Galectins and Cancer Biology
- Pregnancy and preeclampsia studies
- Hepatitis Viruses Studies and Epidemiology
- COVID-19 Impact on Reproduction
- Rural Development and Agriculture
- Synthesis and Biological Evaluation
- Heme Oxygenase-1 and Carbon Monoxide
- Pneumocystis jirovecii pneumonia detection and treatment
- Cardiovascular Issues in Pregnancy
- Corneal Surgery and Treatments
Universidade Federal de Uberlândia
2014-2024
The combination of sulfadiazine and pyrimethamine plus folinic acid is the conventional treatment for congenital toxoplasmosis. However, this classical presents teratogenic effects bone marrow suppression. In sense, new therapeutic strategies are necessary to reduce these improve control infection. context, biogenic silver nanoparticles (AgNp-Bio) appear as a promising alternative since they have antimicrobial, antiviral, antiparasitic activity. purpose study investigate action AgNp-Bio in...
Classical treatment for congenital toxoplasmosis is based on combination of sulfadiazine and pyrimethamine plus folinic acid. Due to teratogenic effects bone marrow suppression caused by pyrimethamine, the establishment new therapeutic strategies indispensable minimize side improve control infection. Previous studies demonstrated that enrofloxacin toltrazuril reduced incidence Neospora caninum Toxoplasma gondii The aim present study was evaluate efficacy in T. infection human trophoblast...
Toxoplasma gondii is able to infect a wide range of vertebrates, including humans. Studies show that cyclooxygenase-2 (COX-2) modulator immune response in multiple types infection, such as Trypanosoma cruzi. However, the role COX-2 during T. infection still unclear. The aim this study was investigate by moderately or highly virulent strains Calomys callosus rodents and human THP-1 cells. C. were infected with 50 cysts (ME49), treated inhibitors (meloxicam celecoxib) evaluated check body...
MIF is a pro-inflammatory cytokine that plays important roles in physiology, pathology, immunology and parasitology, including the control of infection by protozoa parasites such as Toxoplasma gondii. As function congenital toxoplasmosis not fully elucidated yet, present study brings new insights for T. gondii absence based on pregnant C57BL/6MIF-/- mouse models. Pregnant C57BL/6WT mice were infected with 05 cysts (ME49 strain) first day pregnancy (dop) euthanized at 8 dop. Non-pregnant...
Macrophage migration inhibitory factor (MIF) is a potent pro-inflammatory cytokine, which mediates the regulation of diverse cellular functions. It produced by extravillous trophoblastic cells and has been found to be involved in pathogenesis diseases caused some protozoa, including Toxoplasma gondii. Previous studies demonstrated ability T. gondii take advantage MIF action human trophoblast cells. However, gondii-infected (HTR8/SVneo cell line) not fully investigated. The present study...
Galectin-3 (Gal-3) is a β-galactoside-binding lectin expressed in cells of the placental microenvironment. This involved various biological processes, such as modulation immune system and control parasitic illness. Toxoplasma gondii infection can lead to congenital transmission cause miscarriages, prematurity fetal anomalies. However, little known about role Gal-3 T. study aimed unravel underlying mechanisms during infection. For this purpose, we promoted knockdown expression by using RNA...
Macrophage Migration Inhibitory Factor (MIF) is a cytokine that was first described as protein able to inhibit the random migration of macrophages. Nowadays, MIF has been associated with several others functions related physiology pathology and control infection by intracellular parasites. In this sense, some methodologies have proposed therapeutic strategy or clarify roles in parasitology. present study we aimed investigate anti-MIF ISO-1 strategies human placenta evaluate how these...