A5044682895- Toxoplasma gondii Research Studies
- Parasites and Host Interactions
- Parasitic Infections and Diagnostics
- Heme Oxygenase-1 and Carbon Monoxide
- Research on Leishmaniasis Studies
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Prenatal Substance Exposure Effects
- Natural product bioactivities and synthesis
- Dermatological diseases and infestations
- Iron Metabolism and Disorders
- Synthesis and Biological Evaluation
- Homelessness and Social Issues
- Trypanosoma species research and implications
- Neonatal Health and Biochemistry
- Rabies epidemiology and control
- Immune Response and Inflammation
- T-cell and Retrovirus Studies
- Galectins and Cancer Biology
- Hemoglobinopathies and Related Disorders
- Folate and B Vitamins Research
- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
Universidade Federal de Uberlândia
2019-2024
Escola Bahiana de Medicina e Saúde Pública
2011
Iron is an important constituent of our environment, being necessary for both mammalian and pathogenic protozoa survival. Iron-containing proteins exert a wide range biological processes such as biodegradation biosynthesis, well immune function, fetal development, physical mental well-being. This work aimed to investigate the effect iron deprivation in Toxoplasma gondii infection outcome. C57BL/6 mice were orally infected with T. treated chelator, deferoxamine, or supplemented (ferrous...
Galectin-3 (Gal-3) is a β-galactoside-binding lectin expressed in cells of the placental microenvironment. This involved various biological processes, such as modulation immune system and control parasitic illness. Toxoplasma gondii infection can lead to congenital transmission cause miscarriages, prematurity fetal anomalies. However, little known about role Gal-3 T. study aimed unravel underlying mechanisms during infection. For this purpose, we promoted knockdown expression by using RNA...
Heme oxygenase-1 (HO-1) enzyme exerts beneficial effects at the maternal-fetal interface, especially in trophoblasts, being involved survival and maturation of these cell phenotypes. Trophoblast cells play essential roles throughout pregnancy, gateway for pathogens vertically transmitted, such as Toxoplasma gondii . It was previously shown that HO-1 activity control T. infection vivo ; however, its contribution trophoblast during infection, remain undefined. Thus, this study aimed to...
The enzyme heme oxygenase-1 (HO-1) has cytoprotective effects by catalyzing the degradation of to produce carbon monoxide, iron and biliverdin. Furthermore, HO-1 activity been associated with successful pregnancy. On other hand, in context certain inflammatory conditions, can induce overload cell death. To investigate role gestational malaria, pregnant BALB/c mice were infected Plasmodium berghei ANKA early, mid late gestation. We found that malaria affected pregnancy outcome three periods...
5-Lipoxygenase (5-LO) is an enzyme required for the production of leukotrienes and lipoxins interferes with parasitic infections. In vitro, Toxoplasma gondii inhibits leukotriene B4 (LTB4) production, mice deficient in 5-LO are highly susceptible to infection. The aim this study was investigate effects pharmacological inhibition pathway exogenous LTB4 supplementation during experimental toxoplasmosis. For purpose, C57BL/6 were orally infected T. treated or MK886 (a selective inhibitor...
Toxoplasma gondii is a protozoan with worldwide distribution and triggers strong Th1 immune response in infected susceptible hosts. On the contrary, most helminth infections are characterized by Th2 use of helminth-derived antigens to regulate inflammatory disorders has been broadly investigated.The aim this study was investigate whether treatment Strongyloides venezuelensis antigen extract (SvAg) would alter against T gondii.C57BL/6 mice were orally treated SvAg, parasitological,...
Background HTLV-1 infection alters the immune function and increases risk of several infectious diseases. In this meta-analysis, we assess association between HTLV- 1/2 and active tuberculosis (TB). Methods Four databases were searched for relevant articles that describe frequency HTLV- 1/2 among TB patients control groups healthy individuals or patients without a history TB. Data analyzed using EasyMA software. Results The search yielded two hundred eight articles. Six met...
Canine demodicosis is a common inflammatory parasitic skin disease caused by Demodex mites. House dust mites, such as Dermatophagoides spp., play an important role in the pathogenesis of canine atopic dermatitis (AD). The goal this experimental work was to investigate whether demodectic dogs could be previously exposed/sensitized house mites’ antigens. First prevalence southeastern region Brazil investigated analyzing clinical files that were admitted Veterinary Hospital. Subsequently, IgG...
Trichoderma are fungi that well-known to inhibit the growth of a variety plant pathogens. Currently, there is an increasing search for new drugs treat toxoplasmosis. The aims this study were investigate effect ExtTs in control Toxoplasma gondii proliferation vitro and course toxoplasmosis mouse model. Firstly, cytotoxicity was evaluated by cultivating macrophages with different concentrations extract cell viability assessed MTT assay. Next, infectivity T. treated analyzed infecting J774...