A5027896749- Research on Leishmaniasis Studies
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Trypanosoma species research and implications
- Infectious Diseases and Tuberculosis
- Immunodeficiency and Autoimmune Disorders
- Urticaria and Related Conditions
- Eosinophilic Disorders and Syndromes
- Toxin Mechanisms and Immunotoxins
- Leprosy Research and Treatment
- Health, Nursing, Elderly Care
- Immune responses and vaccinations
- T-cell and Retrovirus Studies
- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- Antifungal resistance and susceptibility
- Pleural and Pulmonary Diseases
- Cytokine Signaling Pathways and Interactions
- Infectious Diseases and Mycology
- Hemoglobinopathies and Related Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Science and Education Research
- Parasites and Host Interactions
- Cystic Fibrosis Research Advances
- Fungal Infections and Studies
Fundação Oswaldo Cruz
2014-2025
Universidade Salvador
2023-2025
Universidade do Estado da Bahia
2020-2024
Sadick Dermatology
2024
Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais
2020-2024
National Council for Scientific and Technological Development
2024
Universidade Federal da Bahia
1991-2021
Fundação de Amparo à Pesquisa do Estado da Bahia
2021
Escola Bahiana de Medicina e Saúde Pública
2003-2017
Complexo Hospitalar Universitário Professor Edgard Santos
2012
Mycobacterium tuberculosis infects one-third of the world's human population. This widespread infection depends on organism's ability to escape host defenses by gaining entry and surviving inside macrophage. DNA sequences M. have been cloned; these confer a nonpathogenic Escherichia coli strain an invade HeLa cells, augment macrophage phagocytosis, survive for at least 24 hours capacity gain into mammalian cells was localized two distinct loci cloned fragment.
Diabetes increases susceptibility to infections, including Leishmania braziliensis (Lb). Our group previously demonstrated that diabetic patients with cutaneous leishmaniasis (CL) take longer heal lesions compared non-diabetics. Since macrophages play a critical role in CL pathogenesis, we investigated how high glucose levels impact their response during Lb infection. Macrophages cultured conditions showed increased parasite load than those normal conditions. The production of inflammatory...
Cutaneous leishmaniasis (CL), characterized by an ulcerated lesion, is the most common clinical form of human leishmaniasis. Before ulcer develops, patients infected with Leishmania (Viannia) braziliensis present a small papule at site sandfly bite, referred to as early cutaneous (E-CL). Two four weeks later typical which considered here late CL (L-CL). Although there great deal known about T-cell responses in L-CL, little information situ inflammatory response E-CL. Histological sections...
Skin lesions from patients infected with Leishmania braziliensis has been associated inflammation induced by cytotoxic CD8+ T cells. In addition, cell-mediated cytotoxicity not linked to parasite killing. Meanwhile, the role played natural killer (NK) cells in cutaneous leishmaniasis (CL) remains poorly understood.In this study, we observed higher frequencies of NK peripheral blood CL compared healthy subjects, and that expressed more interferon-γ, tumor necrosis factor (TNF), granzyme B,...
Journal Article A proposed new clinical staging system for patients with mucosal leishmaniasis Get access Hélio A. Lessa, Lessa aServiço de Imunologia, Complexo Hospitalar Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil Search other works by this author on: Oxford Academic PubMed Google Scholar Marcus M. Luiz Henrique Guimarães, Guimarães Clara Mônica F. Lima, Lima Sergio Arruda, Arruda Paulo R. Machado, Machado Edgar Carvalho ⁎ BrazilbInstituto...
This paper reports the overall effects of three lectins, extracted from Canavalia brasiliensis, Dioclea violacea, and D. grandiflora, on BALB/c mice popliteal draining lymph nodes. These lectins have presented high stimulatory capacity node T cells. Additionally, they were able to induce apoptosis inflammation (frequently associated with endothelial venule necrosis). The data here suggest that Diocleinae studied can stimulate in vivo cell activation apoptosis, as well present important side effects.
Cutaneous leishmaniasis (CL) is the most frequent clinical form of tegumentary and characterised by a single or few ulcerated skin lesions that may disseminate into multiple ulcers papules, which characterise disseminated (DL). In this study, cells were quantified using immunohistochemistry haematoxylin eosin staining (CD4+, CD68+, CD20+, plasma neutrophils) histopathology was used to determine level inflammation in biopsies from patients with early CL, late CL DL (ulcers papules). The...
Cutaneous leishmaniasis exhibits a spectrum of clinical presentations dependent upon the parasites' persistence and host immunopathologic responses. Although cytolytic CD8 T cells cannot control parasites, they significantly contribute to pathologic In murine model cutaneous leishmaniasis, we previously found that NKG2D plays role in ability promote disease leishmanial lesions. Here, investigated whether human disease. We its ligands were expressed within lesions from L....
IFN-γ and TNF play critical roles in the control of Mycobacterium tuberculosis infection. Despite leading to an exaggerated production inflammatory cytokines, HTLV-1 infection increases risk developing (TB). However, immune mechanisms accounting for this phenomenon are still unclear. The aim study was evaluate immunological aspects HTLV-1/M. co-infection. In cross-sectional study, levels TNF, IL-1β, IL-17 were determined by ELISA supernatants either unstimulated or tuberculin purified...
Abstract Current diagnostic tests for tuberculosis (TB) are not able to predict reactivation disease progression from latent TB infection (LTBI). The main barrier predicting is the lack of our understanding host biomarkers associated with active disease. Here, we applied an immune-based gene expression profile by NanoString platform identify whole blood markers that can distinguish other lung diseases (OPD), and could be further evaluated as a predictor. Among 23 candidate genes...
Cutaneous leishmaniasis (CL) is caused by the bite of infected sand fly, which inoculates parasites Leishmania spp and triggers an immune response. An exacerbated cutaneous inflammatory response crucial for controlling parasite burden but can also promote tissue damage. This study aimed to characterize populations natural killer (NK), CD57+, CD4+ CD8+ T cells, CD20+ B as well CD68+ macrophages, in biopsies ulcerated CL lesions, quantify production perforin+, grazyme B+, interleukin 1 beta...
Abstract IL-4 regulates B cell differentiation and monocyte functions. Protein kinases, such as kinase C (PKC), transduce receptor signals. The involvement of PKC in IL-4R signaling was investigated human monocytes. Treatment with (10 ng/ml) for 10 min resulted a significant redistribution the activity from cytosol to nuclear fraction. Total localized fraction IL-4-treated control monocytes was, respectively, 68 19%. In contrast, similar found membrane cells. kinetics IL-4-mediated were...
Biopsies from human localized cutaneous lesions (LCL n = 7) or disseminated (DL 8) cases were characterized according to cellular infiltration,frequency of cytokine (IFN-<FONT FACE=Symbol>g</font>, TNF-alpha) iNOS enzyme producing cells. LCL, the most usual form disease with usually one two lesions, exhibits extensive tissue damage. DL is a rare widespread throughout body; exhibiting poor parasite containment but less We demonstrated that LCL exhibit higher frequency B lymphocytes and...
Disseminated leishmaniasis (DL) differs from other clinical forms of the disease due to presence many non-ulcerated lesions (papules and nodules) in non-contiguous areas body. We describe histopathology DL CD4-, CD20-, CD68-, CD31- von Willebrand factor (vW)-positive cells inflamed area. analysed eighteen biopsies quantified expression CD4, CD20, CD68, CD31 vW using Image-Pro software (Media Cybernetics). Diffuse lymphoplasmacytic perivascular infiltrates were found dermal skin. Inflammation...
BackgroundIn this study, we determined the accuracy of anti-Leishmania IgG and subclasses to distinguish clinical forms American tegumentary leishmaniasis (ATL) relationship between antibodies levels with cytokine production severity ATL.MethodsParticipants were 40 patients cutaneous (CL), 20 mucosal (ML), disseminated (DL), individuals subclinical Leishmania braziliensis infection (SC). Diagnosis was performed by DNA L. or IFN-γ in SC. soluble antigen supernatants mononuclear cells detected...
Introduction Leishmania braziliensis infection induces a large spectrum of lesions that clinically manifest as nodules or papules progress to ulcers. Although it is already known T helper cells predominate in the lesions, cytotoxic have also been reported be present, and their role leishmaniasis immunopathogenesis not well known. This study investigated amounts CD8+ granzyme B+ different clinical forms human cutaneous (CL). Methods Forty tissue fragments from early (E-CL) late CL (L-CL)...
Cutaneous leishmaniasis (CL), caused by Leishmania braziliensis, is the most important presentation of tegumentary (TL) in Latin American. While role dogs as reservoirs infantum, and clinic features canine visceral leishmanisis are well described, little known about importance transmission L. braziliensis to humans. In present study, we determine frequency infection with cutaneous mucosal ulcers an endemic area CL. We also describe clinical manifestations histopathologic features, if...
Poorly controlled diabetes mellitus leads to several comorbidities, including susceptibility infections. Hyperglycemia increases phagocyte responsiveness, however immune cells from people with show inadequate antimicrobial functions. We and others have shown that aberrant production of leukotriene B4 (LTB4) is detrimental host defense in models bacterial infection. Here, we will unveil the consequences high glucose outcome Leishmania braziliensis skin infection determine role LTB4 human...