A5052201487- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Leptospirosis research and findings
- Vector-borne infectious diseases
- Vector-Borne Animal Diseases
- Insect and Pesticide Research
- Viral Infections and Vectors
- Parasites and Host Interactions
- Insect Pest Control Strategies
- Virology and Viral Diseases
- Psychodrama and Leishmaniasis Studies
- Toxin Mechanisms and Immunotoxins
- Heat shock proteins research
- Viral gastroenteritis research and epidemiology
- Business and Management Studies
- Virus-based gene therapy research
- Parasite Biology and Host Interactions
- T-cell and Retrovirus Studies
- Parasitic Diseases Research and Treatment
- Zoonotic diseases and public health
- Insect symbiosis and bacterial influences
- Healthcare during COVID-19 Pandemic
- Insect Resistance and Genetics
- Child Nutrition and Water Access
- Vaccine Coverage and Hesitancy
Fundação Oswaldo Cruz
2015-2025
Universidade Federal da Bahia
2014-2024
National Council for Scientific Research
2024
Scientific Research and Development (Germany)
2024
Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais
2014-2022
Ministério da Saúde
2014-2016
Hospital Ana Nery
2014
Background Leptospirosis has emerged as an urban health problem slum settlements have rapidly spread worldwide and created conditions for rat-borne transmission. Prospective studies not been performed to determine the disease burden, identify risk factors infection provide information needed guide interventions in these marginalized communities. Methodology/Principal Findings We enrolled followed a cohort of 2,003 residents from community city Salvador, Brazil. Baseline one-year serosurveys...
Background Rat-borne leptospirosis is an emerging zoonotic disease in urban slum settlements for which there are no adequate control measures. The challenge elucidating risk factors and informing approaches prevention the complex heterogeneous environment within slums, vary at fine spatial scales influence transmission of bacterial agent. Methodology/Principal Findings We performed a prospective study 2,003 residents city Salvador, Brazil during four-year period (2003–2007) used...
Background The Norway rat (Rattus norvegicus) is the principal reservoir for leptospirosis in many urban settings. Few studies have identified markers infestation slum environments while none evaluated association between household and Leptospira infection humans or use of as a predictive model to stratify risk leptospirosis. Methodology/Principal Findings We enrolled cohort 2,003 residents from Salvador, Brazil 2004, followed during four annual serosurveys identify serologic evidence...
Vaccination is a major strategy to prevent the coronavirus disease 2019 (COVID-19). However, information about factors associated with men and women intention be vaccinated are scarce. To determine COVID-19 vaccine acceptance identify hesitancy according sex, we performed cross-sectional population-based random survey in Salvador, Brazil between Nov/2020-Jan/2021. Participants were interviewed obtain data on receive pay for vaccine, as well demographics, comorbidities, influenza vaccination...
The sand fly Lutzomyia longipalpis is primarily responsible for the transmission of visceral leishmaniasis (VL) in New World, and dogs are considered to be main urban reservoir this disease. In order improve efficacy control measures, it essential assess capacity Leishmania infantum vector by naturally infected dogs. present study investigated existence correlations between canine clinical presentation intensity parasite load blood, skin spleen addition, we also attempted establish tissue...
Visceral Leishmaniasis (VL) has spread to many urban centers worldwide. Dogs are considered the main reservoir of VL, because canine cases often precede occurrence human cases. Detection and euthanasia serologically positive dogs is one primary VL control measures utilized in some countries, including Brazil. Using accurate diagnostic tests can minimize undesirable consequence this measure, culling false-positive dogs, reduce maintenance false-negative endemic areas. In December 2011,...
Host tissues affected by Leishmania infantum have differing degrees of parasitism. Previously, the use different biological to detect L. DNA in dogs has provided variable results. The present study was conducted evaluate accuracy molecular diagnostic testing (qPCR) from an endemic area for canine visceral leishmaniasis (CVL) determining which tissue type highest rate parasite detection. Fifty-one symptomatic were tested CVL using serological, parasitological and methods. Latent class...
Oleylphosphocholine (OlPC) is a miltefosine derivative that more effective than against Leishmania infections in rodent models. Because canines are natural host for , the improved treatment of canine leishmaniasis essential both veterinary medicine and as large animal model clinical development. Oleylphosphocholine, at dosage 4 mg/kg/day 28 days, was compared with approved regimen 2 days 33 naturally infected Brazilian dogs (17 randomly assigned to receive OlPC versus 16 designated...
Blood-sucking phlebotomine sand flies (Diptera: Psychodidae) transmit leishmaniasis as well arboviral diseases and bartonellosis. Sand fly females become infected with Leishmania parasites them while imbibing vertebrates' blood, required a source of protein for maturation eggs. In addition, both males consume plant-derived sugar meals energy. Plant may comprise sugary solutions such nectar or honeydew (secreted by plant-sucking homopteran insects), phloem sap that obtain piercing leaves...
Background Visceral leishmaniasis (VL) is a zoonosis of great importance. Limitations in current VL control measures compromise efficacy, indicating the need to implement new strategies. The aim this study was evaluate effectiveness mass use deltamethrin-impregnated collars dogs as public health measure and prevent canine visceral (CVL). Methodology An interventional implemented two endemic areas district Monte Gordo (Bahia-Brazil): an intervention area, which seronegative were collared,...
Abstract Clinical manifestations in canine visceral leishmaniasis (CVL) have not been clearly associated with immunological status or disease progression. We simultaneously assessed biomarkers of inflammation, immune activation, oxidative stress, and anti-sand fly saliva IgG concentrations dog sera different clinical to characterize a biosignature CVL severity. In cross-sectional exploratory study, random population 70 dogs from an endemic area Brazil was classified according severity...
Human visceral leishmaniasis occurs in periodic waves endemic areas of Brazil. In this study we followed the prevalence human and Leishmania infantum infection stray dogs an area at periods time between 1997 2010. Prevalence had two peaks (40 cases) 2006 with sharp declines to 2 cases 2001 5 2008. Similar fluctuations were also observed occurrence positive spleen culture anti-Leishmania serology dogs, although proportion active parasitism remained relatively high even low disease. These...
Background Dogs are considered sentinels in areas of Trypanosoma cruzi transmission risk to humans. ELISA is generally the method choice for diagnosing T. exposure dogs, but its performance substantially depends on antigenic matrix employed. In previous studies, our group has developed four chimeric antigens (IBMP-8.1, 8.2, 8.3, and 8.4) evaluated their potential For human sera, these presented superior diagnostic performances as compared commercial tests available Brazil, Spain, Argentina....
INTRODUCTION Portal hypertension and periportal fibrosis commonly occur in severe Schistosoma mansoni infection. Changes lipid profile elevated levels of circulating liver enzymes have also been described infected individuals. The present study sought to assess the alterations laboratory parameters associated with disorder individuals by S. who visited a private routine service. Levels (gamma-glutamyl transferase [γ-GT], aspartate transaminase [AST], alanine [ALT], alkaline phosphatase...
Visceral leishmaniasis (VL) is a serious public health challenge in Brazil and dogs are considered to be the main urban reservoir of causative agent. The culling animals control VL some countries makes accurate diagnosis canine (CVL) essential. Recombinant antigens rLci1A rLci2B were selected from cDNA library Leishmania infantum amastigotes due their strong potential as candidates diagnostic testing for CVL. present multicentric study aimed evaluate sensitivity prototype test using these...
Cutaneous leishmaniasis (CL), caused by Leishmania braziliensis, is the most important presentation of tegumentary (TL) in Latin American. While role dogs as reservoirs infantum, and clinic features canine visceral leishmanisis are well described, little known about importance transmission L. braziliensis to humans. In present study, we determine frequency infection with cutaneous mucosal ulcers an endemic area CL. We also describe clinical manifestations histopathologic features, if...
Visceral leishmaniasis (VL) is a zoonosis caused by the protozoan Leishmania infantum and in Brazil transmitted mainly bite of Lutzomuyia longipalpis sand flies. Data about presence, distribution, natural infection rate, seasonal monthly dynamics vector population are important for optimizing measures to control VL endemic areas. This study aimed identify fly fauna an area detect prevalence L. Lu. elucidate influence bioclimatic factors on fluctuations this vector. HP light traps were set...
Domestic dogs are the principal reservoir hosts of Leishmania infantum in regions where visceral leishmaniasis (VL) is endemic. Although serologic methods frequently used for screening infected dogs, antibody-based tests require further assessment, due to lack sensitivity and specificity. In this study, we employed a multi-antigen printing immunoassay (MAPIA) compare antibody responses novel recombinant proteins L. with potential detection canine VL. MAPIA strips were prepared employing 12...
Background Canine Visceral leishmaniasis (CVL) is a serious public health problem, thus for its control, the Ministry of Health in Brazil recommends rapid diagnosis and euthanasia seropositive dogs endemic areas. Therefore, our group had previously selected six recombinant proteins (rLci1, rLci2, rLci4, rLci5, rLci8, rLci12) due to their high potential CVL diagnostic testing. The present study aims produce an immunodiagnostic test using aforementioned antigens, improve performance...
Dogs living in areas of Leishmania (Viannia) braziliensis transmission may present canine tegumentary leishmaniasis (CTL) characterized by cutaneous or muzzle ulcers as well asymptomatic L. infection. It is not clear if dogs participate the chain to humans. However, remain with chronic for a long time, and there are no public policies about CTL, these animals die sacrificed. Here we compare efficacy intralesional meglumine antimoniate 0.9% NaCl solution CTL treatment. This randomized control...