A5058319433- Tuberculosis Research and Epidemiology
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycobacterium research and diagnosis
- Mosquito-borne diseases and control
- Hepatitis C virus research
- HIV Research and Treatment
- Hepatitis B Virus Studies
- Diagnosis and treatment of tuberculosis
- Pneumonia and Respiratory Infections
- HIV/AIDS Research and Interventions
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Vector-Borne Animal Diseases
- T-cell and Retrovirus Studies
- Malaria Research and Control
- Viral Infections and Vectors
- HIV/AIDS drug development and treatment
- vaccines and immunoinformatics approaches
- Infectious Diseases and Tuberculosis
- Animal Disease Management and Epidemiology
- Immune responses and vaccinations
- Machine Learning in Bioinformatics
- Respiratory viral infections research
Fundação Oswaldo Cruz
2016-2025
Faculdade de Tecnologia e Ciências
2024
Knowledge Integration (United Kingdom)
2021
KU Leuven
2021
Rega Institute for Medical Research
2021
ORCID
2020
Universidade Estadual de Feira de Santana
2017-2018
University of Oslo
2018
Universidade de São Paulo
2009-2010
Universidade Cidade de São Paulo
2010
This study aims to describe the oral microbiome diversity and prevalence of ARGs in periodontal health disease.The human cavity harbors a complex microbial community known as microbiome. These organisms are regularly exposed selective pressures, such usage antibiotics, which drive evolution acquisition antibiotic resistance genes (ARGs). Resistance among bacteria jeopardizes not only therapy for infections, but also extra-oral infections caused by bacterial translocation.We carried out...
Host resistance to Mycobacterium tuberculosis (Mtb) infection requires the activities of multiple leukocyte subsets, yet roles different innate effector cells during are incompletely understood. Here we uncover an unexpected association between eosinophils and Mtb infection. In humans, decreased in blood but enriched resected human lung lesions autopsy granulomas. An influx is also evident infected zebrafish, mice, nonhuman primate granulomas, where they functionally activated degranulate....
Abstract Oxidative stress triggers ferroptosis, a form of cellular necrosis characterized by iron-dependent lipid peroxidation, and has been implicated in Mycobacterium tuberculosis (Mtb) pathogenesis. We investigated whether Bach1, transcription factor that represses multiple antioxidant genes, regulates host resistance to Mtb. found BACH1 expression is associated clinically with active pulmonary tuberculosis. Bach1 deletion Mtb-infected mice increased glutathione levels Gpx4 inhibit...
The genotypes of hepatitis B (HBV) and delta (HDV) viruses circulating among fulminant cases from the western Amazon Basin Brazil were characterized in this study. HBV HDV isolates obtained liver samples 14 patients who developed died during 1978-1989. DNA RNA detected all samples. Phylogenetic analyses sequences showed that they clustered with previously genotype 3 (HDV-3). F, A D found 50.0, 28.6 21.4 % cases, respectively. These results confirm predominance HDV-3 South America its...
Abstract Background Plasmodium vivax malaria clinical outcomes are a consequence of the interaction multiple parasite, environmental and host factors. The molecular genetic determinants driving susceptibility to disease severity in this infection largely unknown. Here, network analysis large-scale data from significant number individuals with different presentations P. was performed an attempt identify patterns association between various candidate biomarkers outcomes. Methods A...
There is currently no system to track the emergence of Zika virus (ZIKV) subtypes. We developed a surveillance able retrieve sequence submissions and further classify distinct ZIKV genotypes in world. This approach was detect new occurrence from an African lineage Brazil 2019.
HIV/Mycobacterium tuberculosis (Mtb) co-infected individuals have an increased risk of prior to loss peripheral CD4 T cells, raising the possibility that HIV co-infection leads cell depletion in lung tissue before it is evident blood. Here, we use rhesus macaques study early effects simian immunodeficiency virus (SIV) on pulmonary granulomas. Two weeks after SIV inoculation Mtb-infected macaques, Mtb-specific cells are dramatically depleted from granulomas, blood, airways, and lymph nodes,...
Introduction Evidence exists that some individuals possibly resist (resisters) Mycobacterium tuberculosis (Mtb) infection despite sustained exposure, but the protective mechanisms involved are not yet fully understood. We aimed to investigate immune responses induced by stimulation with live Mtb in resisters compared those latent TB (LTBI). Methods HIV-uninfected healthcare workers working facilities for over 5years were screened sensitization using interferon-gamma release assay (IGRA) and...
Summary Several new direct‐acting antiviral ( DAA ) drugs are in development for chronic hepatitis C viral HCV infection, and NS 3‐ 4A serine protease the 5B RNA ‐dependent polymerase have been major targets. variants displaying drug‐resistant phenotypes observed both vitro during clinical trials. Our aim was to characterize amino acid changes at positions previously associated with resistance 3) 5B) regions from treatment‐naïve patients infected genotypes 1a, 1b 3a. All 1383 3 sequences...
Localised cutaneous leishmaniasis (LCL) is the most common form of characterised by single or multiple painless chronic ulcers, which commonly presents with secondary bacterial infection. Previous culture-based studies have found staphylococci, streptococci, and opportunistic pathogenic bacteria in LCL lesions, but there been no comparisons to normal skin. In addition, this approach has strong bias for determining composition. The present study tested hypothesis that communities lesions...
BackgroundA major goal of tuberculosis (TB) epidemiological studies is to obtain results that can be generalized the larger population with TB. The ability extrapolate findings on determinants TB treatment outcomes also important.MethodsWe compared baseline clinical and demographic characteristics anti-TB between persons enrolled in Regional Prospective Observational Research Tuberculosis (RePORT)-Brazil cohort June 2015 2019, registry cases reported Brazilian National Program (Information...
Blood-sucking phlebotomine sand flies (Diptera: Psychodidae) transmit leishmaniasis as well arboviral diseases and bartonellosis. Sand fly females become infected with Leishmania parasites them while imbibing vertebrates' blood, required a source of protein for maturation eggs. In addition, both males consume plant-derived sugar meals energy. Plant may comprise sugary solutions such nectar or honeydew (secreted by plant-sucking homopteran insects), phloem sap that obtain piercing leaves...
It is unclear whether diabetes or prediabetes affects unfavorable treatment outcomes and death in people with tuberculosis (PWTB).
Abstract Recent studies have demonstrated an increased prevalence of human immunodeficiency virus type 1 (HIV‐1) subtype C in southern Brazil. Although Santa Catarina State (SC) is located this area and presents one the country's highest incidences HIV/AIDS, knowledge on molecular epidemiology HIV‐1 such lacking. The aim study was to investigate diversity epidemiological profile HIV‐1‐infected patients from SC. DNA samples were PCR amplified subtypes determined using both env gag genes by...
Approximately 1.4 million people die annually worldwide from tuberculosis. Large epidemiologic studies can identify determinants of unfavorable clinical outcomes according to age, which guide public health policy implementation and management improve outcomes. We obtained data the national tuberculosis case registry; were reported Brazilian National Program (SINAN) between 2010 2019. Clinical variables compared age groups (child: <10 years, young: 10-24years, adult: 25-64years, elderly:...
Tuberculosis-diabetes mellitus (TB-DM) is linked to a distinct inflammatory profile, which can be assessed using multi-omics analyses. Here, machine learning algorithm was applied multi-platform data, including cytokines and gene expression in peripheral blood eicosanoids urine, Brazilian multi-center TB cohort. There were four clinical groups: TB-DM(n = 24), only(n 28), DM(HbA1c ≥ 6.5%) 11), control group of close contacts who did not have or DM(n 13). After cross-validation, baseline...
SARS-CoV-2 infection leads to vastly divergent clinical outcomes ranging from asymptomatic fatal disease. Co-morbidities, sex, age, host genetics and vaccine status are known affect disease severity. Yet, how the inflammatory milieu of lung at time exposure impacts control viral replication remains poorly understood. We demonstrate here that immune events in mouse closely preceding significantly impact we identify key innate pathways required limit replication. A diverse set pulmonary...
SummaryBackgroundSince 2014, Brazil has gradually implemented the Xpert MTB/RIF (Xpert) test to enhance early tuberculosis (TB) and drug-resistant (DR-TB) detection control, yet its nationwide impact remains underexplored. Our study conducts an intervention time-series analysis (ITSA) evaluate how Xpert's implementation improved TB DR-TB nationwide.Methods1,061,776 cases from Brazil's National Registry (2011–2022) were reviewed ITSA (2011–2019) was used gauge of adoption on notification....
Severity of COVID-19 is affected by multiple factors; however, it not understood how the inflammatory milieu lung at time SARS-CoV-2 exposure affects control viral replication. Here, we demonstrate that immune events in mouse closely preceding infection affect and identify innate pathways limit Pulmonary stimuli including resolved, antecedent respiratory infections with Staphylococcus aureus or influenza, ongoing pulmonary Mycobacterium tuberculosis infection, ovalbumin/alum-induced asthma,...
Leishmania braziliensis is the etiological agent of cutaneous leishmaniasis, a disease with high public health importance, affecting 12 million people worldwide. Although its genome sequence was originally published in 2007, two reference annotations still presents at least 80% genes simply classified as hypothetical or putative proteins. Furthermore, it notable absence non-coding RNA (ncRNA) sequences from species databases. These poorly annotated coding and ncRNAs could be important...