A5108474673- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Antibiotic Resistance in Bacteria
- Cystic Fibrosis Research Advances
- Pneumocystis jirovecii pneumonia detection and treatment
- Streptococcal Infections and Treatments
- Respiratory viral infections research
- Infective Endocarditis Diagnosis and Management
- Tracheal and airway disorders
- Otolaryngology and Infectious Diseases
- Public Health in Brazil
- Healthcare Regulation
- Tuberculosis Research and Epidemiology
- Neonatal and Maternal Infections
- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
- Food Safety and Hygiene
- Urinary Tract Infections Management
- Enterobacteriaceae and Cronobacter Research
- Escherichia coli research studies
- Mycobacterium research and diagnosis
- Salmonella and Campylobacter epidemiology
- Ocular Infections and Treatments
- Oral microbiology and periodontitis research
- Virology and Viral Diseases
Universidade Federal da Bahia
2014-2024
Fundação Oswaldo Cruz
2013-2024
Ministério da Saúde
2007-2024
Hospital Ana Nery
2017-2024
Hospital de São João
2024
Instituto Federal da Bahia
2023
Instituto de Saúde
2019
Faculdades Oswaldo Cruz
2014
Fundação de Amparo à Pesquisa do Estado da Bahia
2011
Ministério da Saúde
2002
Although cerebrospinal fluid (CSF) culture is the diagnostic reference standard for bacterial meningitis, its sensitivity limited, particularly when antibiotics were previously administered. CSF Gram staining and real-time PCR are theoretically less affected by antibiotics; however, it difficult to evaluate these tests with an imperfect standard. from patients suspected meningitis Salvador, Brazil tested culture, stain, using S. pneumoniae, N. meningitidis, H. influenzae specific primers...
A One Health approach for antimicrobial resistance must integrate whole-genome sequencing surveillance data of critical priority pathogens from human, animal and environmental sources to track hot spots routes transmission developing effective prevention control strategies. As part the Grand Challenges Explorations: New Approaches Characterize Global Burden Antimicrobial Resistance Program, we present genomic WHO carbapenemase-resistant, ESBL-producing, and/or colistin-resistant Escherichia...
Surveillance for Haemophilus influenzae meningitis cases was performed in Salvador, Brazil, before and after introduction of H. type b (Hib) immunization. The incidence Hib decreased 69% during the 1-year period initiation immunization (from 2.62 to 0.81 cases/100,000 person-years; P<.001). In contrast, a increased 8-fold 0.02 0.16 P=.008). Pulsed-field gel electrophoretic analysis demonstrated that isolates belonged 2 clonally related groups, both which were found commenced. Therefore,...
Pilus components of Streptococcus pneumoniae encoded by rlrA were recently shown to elicit protection in an animal model infection. Limited data are available on the prevalence operon pneumococci; therefore, we investigated its distribution and antigenic variation among disease-causing strains.The association with serotype genotype evaluated a global panel 424 pneumococci isolates (including 26 drug-resistant clones described Pneumococcal Molecular Epidemiology Network).The islet was found...
Bloodstream infections (BSI) are associated with high morbidity and mortality. This scenario worsens the emergence of drug-resistant pathogens, resulting in which difficult to treat or even untreatable conventional antimicrobials. The aim this study is describe epidemiological aspects BSI caused by multiresistant gram-negative bacilli (MDR-GNB). We conducted a laboratory-based surveillance for bacteremia over 1-year period. bacterial isolates were identified MALDI-TOF/MS antimicrobial...
This study aims to describe the oral microbiome diversity and prevalence of ARGs in periodontal health disease.The human cavity harbors a complex microbial community known as microbiome. These organisms are regularly exposed selective pressures, such usage antibiotics, which drive evolution acquisition antibiotic resistance genes (ARGs). Resistance among bacteria jeopardizes not only therapy for infections, but also extra-oral infections caused by bacterial translocation.We carried out...
Abstract Escherichia coli is a leading cause of invasive bacterial infections in humans. Capsule polysaccharide has an important role pathogenesis, and the K1 capsule been firmly established as one most potent types E. through its association with severe infections. However, little known about distribution, evolution functions across phylogeny, which fundamental to elucidating expansion successful lineages. Using systematic surveys isolates, we show that K1- cps locus present quarter...
O comportamento autolesivo é caracterizado por atos intencionais realizados sem intencionalidade suicida. Esse pode ser classificado de acordo com o tipo e a gravidade, sendo mais prevalente no sexo feminino. aumento da frequência desses comportamentos nos últimos anos reforça necessidade investigação desenvolvimento estratégias intervenção. Deste modo, este estudo teve objetivo identificar prevalência do em estudantes enfermagem. Trata-se um transversal, exploratório abordagem quantitativa,...
We examined strains of Trypanosoma cruzi isolated from patients with acute Chagas disease that had been acquired by oral transmission in the state Santa Catarina, Brazil (2005) and two isolates obtained a marsupial (Didelphis aurita) vector (Triatoma tibiamaculata). These were characterised through their biological behaviour isoenzymic profiles genotyped according to new Taxonomy Consensus (2009) based on discrete typing unities, is, T. genotypes I-VI. All exhibited biodeme type II. In six...
Multidrug-resistant gram-negative bacteria, such as carbapenem and colistin-resistant Klebsiella pneumoniae (ColR-CRKP), represent a major problem for health systems worldwide have high lethality. This study investigated the genetic relationship, antimicrobial susceptibility profile, resistance mechanisms to ColR-CRKP isolates from patients infected/colonized in tertiary hospital Salvador, Bahia/Brazil. From September 2016 January 2018, 46 (56 positive cultures) were enrolled investigation...
In 2010, Brazil introduced the ten-valent pneumococcal conjugate vaccine (PCV10) in national infant immunization program. Limited data on long-term impact of PCV10 are available from lower-middle-income settings. We examined invasive disease (IPD) Salvador, Bahia, over 11 years. Prospective laboratory-based surveillance for IPD was carried out 9 hospitals metropolitan region Salvador 2008 to 2018. defined as Streptococcus pneumoniae cultured a normally sterile site. Serotype determined by...
Since the introduction of Haemophilus influenzae type b (Hib) conjugate vaccines, meningitis caused by serotypes other than Hib has gained in importance. We conducted active hospital-based surveillance for over an 11-year period Salvador, Brazil. H. isolates were serotyped and analyzed polymerase chain reaction, pulsed-field gel electrophoresis, DNA sequencing to identify strains with a specific deletion (IS1016) bexA gene (IS1016-bexA). identified 43 cases non-type influenzae: 28 (65%)...
To combat rising incidence of serogroup C meningococcal disease in the city Salvador, Brazil, Bahia state immunization program initiated routine childhood with conjugate vaccine (MenC) February 2010, followed by mass MenC vaccination residents 10-24 years age from May through August 2010. We analyzed trends reported cases and distribution among isolates identified hospital-based surveillance Salvador January 2000 to December 2011 estimated effectiveness using screening method. Annual...
Abstract Background Prior to the availability of generic third-generation cephalosporins, penicillins were widely used for treatment pneumococcal meningitis in developing countries despite concerns about rising levels penicillin resistance among isolates. We examined impact on outcomes over a ten year period an infectious diseases hospital Brazil. Methods Clinical presentation, antimicrobial therapy and reviewed 548 patients with culture-confirmed from December, 1995, November, 2005....
Abstract Background Group A Streptococcus (GAS) strain diversity varies across different regions of the world, according to low versus high-income countries. These differences may be related geographic, environmental, socioeconomic, or host-related factors. However, local factors also affect diversity. We compared emm types GAS isolates from children with and without sore throat in one large urban setting Brazil. Methods Children 3-15 years age were consecutively recruited slum non-slum...
Streptococcus suis has been widely reported as a pathogen in animals, especially pigs. In terms of human health implications, it characterized zoonosis associated with the consumption pork products and occupational exposure, particularly Southeast Asian countries. Here, we present rare case S. infection Brazil, diagnosed an older adult swine farmer, small rural producer residing semi-arid region Bahia, Brazil.
Respiratory infection is very common in patients suffering from cystic fibrosis (CF). However, the antimicrobial resistance rate of isolates CF not often documented. In this study, 279 respiratory specimens 146 were prospectively collected July to December 2006. Microbiological cultures and susceptibility tests most frequently isolated bacteria performed. Sputum oropharyngeal swabs processed for culture. During study period, 50% harbored Staphylococcus aureus, 35% Pseudomonas aeruginosa,...