Bloodstream infections (BSI) are associated with high morbidity and mortality. This scenario worsens the emergence of drug-resistant pathogens, resulting in which difficult to treat or even untreatable conventional antimicrobials. The aim this study is describe epidemiological aspects BSI caused by multiresistant gram-negative bacilli (MDR-GNB). We conducted a laboratory-based surveillance for bacteremia over 1-year period. bacterial isolates were identified MALDI-TOF/MS antimicrobial...

To provide species distribution and antifungal susceptibility profiles of 358 Trichosporon clinical isolates collected from 24 tertiary-care hospitals.Species identification was performed by sequencing the IGS1 region rDNA. Antifungal testing for amphotericin B, fluconazole, voriconazole posaconazole followed Clinical Laboratory Standards Institute reference method. Tentative epidemiologic cutoff values (97.5% ECVs) antifungals asahii were also calculated.Isolates cultured mostly urine...

Patients presenting with severe COVID-19 are predisposed to acquire secondary fungal infections such as COVID-19-associated candidemia (CAC), which associated poor clinical outcomes despite antifungal treatment. The extreme burden imposed on facilities during the pandemic has provided a permissive environment for emergence of clonal outbreaks multiple Candida species, including C. auris and parapsilosis. Here we report largest CAC outbreak date caused by fluconazole resistant (FLZR)...

Abstract Klebsiella pneumoniae is one of the leading causes bloodstream (BSI) and urinary tract infections (UTI), but limited data available regarding community-acquired (CA) infections. This study characterized clinical aspects CA-BSI CA-UTI caused by K. molecular features isolates, including their resistance profiles. Sixty-five isolates (CA-BSI, n = 24; CA-UTI, 41) underwent antimicrobial susceptibility testing, β-lactamase virulence gene assessment, capsular genotyping, typing. Older...

To investigate the occurrence of Trichosporon asahii fungemia among critically ill COVID-19 patients.From 1 July to 30 September 2020, cases T (TAF) in a Brazilian referral centre were investigated. The epidemiology and clinical courses detailed, along with mycological investigation that included molecular species identification, haplotype diversity analysis antifungal susceptibility testing.Five patients developed TAF period. All five had common risk conditions for TAF: central venous...

Invasive infections caused by Candida spp. are an important problem in immunocompromised patients. There is scarce data on the epidemiology of blood stream candidiasis Salvador, Brazil. This study evaluates risk factors associated with candidemia, among patients admitted to three tertiary, private hospitals, We conducted a case-control, retrospective compare diagnosis candidemia different tertiary hospitals Patients were matched for nosocomial, acquired infections, according causal agent:...

Bloodstream infections (BSIs) are among the most concerning bacterial infections. They one of leading causes morbidity and mortality, occur in 30-70% critical care patients. The prompt identification causative microorganism can help choosing appropriate antimicrobial therapy that will lead to better clinical outcomes. Blood culture is relevant tests for microbiological diagnosis introduction MALDI-TOF significantly decreased time identifying microorganisms. However, it depends on growth...

We report the first two cases of Trichosporon mycotoxinivorans infections in Latin America. also conducted a literature review and microbiological investigation, including that clinical environmental isolates. A 30-year-old man with chronic renal failure had disseminated infection after dialysis 15-year-old boy cystic fibrosis (CF) pulmonary exacerbations positive respiratory samples. relevant revealed deep-seated were related to immunosuppression or invasive devices, while most CF patients...

ABSTRACT The clinical management of meningitis caused by Escherichia coli is greatly complicated when the organism becomes resistant to broad-spectrum antibiotics. We sought characterize antimicrobial susceptibilities, sequence types (ST), and presence known drug resistance genes E. isolates that between 1996 2011 in Salvador, Brazil. then compared these findings those for from community-acquired urinary tract infections (UTI) occurred during same time period city. found 19% cases less than...

Carbapenemases have great importance in the global epidemiological scenario since infections with carbapenemase-producing bacteria are associated high mortality, especially hospitalized patients intensive care units. This study describes two microorganisms producers of New Delhi Metallo-b-lactamase, Klebsiella pneumoniae and Citrobacter freundii, from admitted to a public hospital Salvador, Bahia. These first clinical cases Metallo-b-lactamase described north northeast Brazil. The isolates...

To determine the incidence, aetiology and pneumococcal serotype distribution of community-acquired pneumonia (CAP) in Brazilian adults during a 2-year period.Prospective population-based surveillance study.Patients from two emergency hospitals Brazil were consecutively included this study.A total 111 aged 50 years older with radiographically-confirmed CAP requiring an department visit prospectively enrolled between January 2018 2020.Incidence rates calculated according to age pathogen....

To report the frequency of methicillin-resistant Staphylococcus aureus (MRSA) infection and to compare antimicrobial resistance patterns between community-acquired (CA) nosocomial (NI) strains stratified for methicillin, this retrospective study on patients under 20 years age was conducted from April 1995 December 2005 in a pediatric teaching hospital Salvador, Brazil. Of 308 S. isolated, 185 (60.1%) were reviewed, out which 125 (67.6%) 55 (29.7%) had CA or NI infection, respectively, 5...

This study aimed to estimate the disease burden of BSIs caused by gram-negative bacteria (GNB-BSIs) in a Brazilian hospital from 2015 2019, measured disability-adjusted life-years (DALYs).

Justificativa e objetivos: Infecções Relacionadas à Assistência Saúde (IRAS) são consideradas um problema de saúde pública cujo controle pode minimizar a morbimortalidade dos pacientes. A instituição precoce isolamento contato para pacientes possivelmente colonizados por microrganismos multirresistentes (MR), reduzir sua disseminação os casos IRAS custos hospitalares. O objetivo deste estudo foi avaliar frequência impacto culturas vigilância positivas com (MR) após surto Enterococcus spp....

Deep infections of the extremities are a challenge that threaten limb salvage.To investigate whether results bone and deep tissue cultures from patients with trophic ulcers coincide.A retrospective study was conducted data 54 admitted to Complexo Hospitalar Universitário Professor Edgard Santos, Salvador (BA), Brazil. The analyzed all for whom material foot wounds in loss had been performed using two specimen types: fragments tendon. concordance between sample types total number...

Severe lower extremity wounds have an increased risk of complications and limb loss. The aim this study was to evaluate compare the microbiological profile antibiotic resistance in diabetic nondiabetic patients. A cross-sectional comparative carried out at a public hospital including 111 patients with moderate severe wound infections. Tissue samples were collected during surgical procedure. One hundred four (94%) had positive cultures 88 (79%) Gram-negative microorganism. Among 185 cultured...

A pandemia de COVID-19 acelerou o avanço da resistência bacteriana devido as altas taxas prescrições antibióticos, internações prolongadas em UTIs, uso dispositivos invasivos, além falhas na aplicação medidas prevenção e controle infecções ambientes hospitalares. O objetivo desse trabalho foi avaliar impacto no aumento Enterobacterales Produtoras Carbapenemases (EPC), isolados clínicos um hospital alta complexidade Salvador-BA. No período 2019 a 2022, foram avaliados 566 consecutivos, não...

Candidemia é uma das principais Infecções de Corrente Sanguínea (ICS) em hospitais terciários, associada a maior permanência hospitalar e taxas mortalidade, principalmente pacientes críticos, uso antibióticos, imunossupressores, nutrição parenteral procedimentos invasivos. Nos últimos anos, infecções causadas por Candida não-albicans tem aumentado forma significativa, especialmente C. parapsilosis, tropicalis, glabrata krusei. O objetivo desse trabalho foi descrever prevalência espécies...

In the US only .2% of AIDS patients are afflicted with Isospora belli infection in Brazil less than 1% were diagnosed isosporosis while Haiti 15% present this infection. 7 cases chronic diarrhea caused by presented. The diagnosis was established direct stool examination using modified Ziehl-Neelsen coloration test. All treated 800 mg sulfamethoxazole and 160 trimetoprim orally 4 times/day for 10 days subsequently 2 weeks maintaining a daily dose 3 times/week prophylaxis recurrence. had...

As Infecções de Corrente Sanguínea (ICS) causadas por Enterobacterales são eventos frequentes e relacionados à elevada morbimortalidade, principalmente quando isolados resistentes aos carbapenêmicos. No Brasil, o primeiro relato produtores Carbapenemases (ERC) ocorreu em 2005, enquanto a detecção da carbapenemase do tipo KPC aconteceu pela primeira vez 2009. A partir então, outros relatos surgiram no país, mas para alguns estados brasileiros os dados ainda escassos, como é caso Bahia. Assim,...