A5072199748- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Plant Pathogens and Fungal Diseases
- Infectious Diseases and Mycology
- Bacterial Identification and Susceptibility Testing
- Nail Diseases and Treatments
- Yeasts and Rust Fungi Studies
- Plant Disease Resistance and Genetics
- Mycorrhizal Fungi and Plant Interactions
- Infections and bacterial resistance
- Reproductive tract infections research
- Pneumocystis jirovecii pneumonia detection and treatment
- Fungal Biology and Applications
- Cystic Fibrosis Research Advances
- Probiotics and Fermented Foods
- Bacterial biofilms and quorum sensing
- Antimicrobial Peptides and Activities
- Legionella and Acanthamoeba research
- Mycotoxins in Agriculture and Food
- Phytochemistry Medicinal Plant Applications
- Identification and Quantification in Food
- Genomics and Phylogenetic Studies
- Essential Oils and Antimicrobial Activity
- Property Rights and Legal Doctrine
- Maternal and Neonatal Healthcare
Universidade de São Paulo
2025
Westerdijk Fungal Biodiversity Institute
2021-2025
Universidade Federal de São Paulo
2016-2025
Universidade Federal do Paraná
2025
Institut Pasteur
2023
King Saud University
2023
Universidade Federal de Pernambuco
2016
Centro Universitário Eurípedes de Marilia
2008
Universidade Estadual do Oeste do Paraná
2008
In December 2020, Candida auris emerged in Brazil the city of Salvador. The first two C. colonized patients were same COVID-19 intensive care unit. Antifungal susceptibility testing showed low minimal inhibitory concentrations 1 µg/mL, 2 0.03 µg/L, and 0.06 µg/mL for amphotericin B, fluconazole, voriconazole, anidulafungin, respectively. Microsatellite typing revealed that strains are clonal belong to South Asian clade auris. travel restrictions during pandemic absence history among lead...
Abstract Objectives To describe the first outbreak of Candida auris in Brazil, including epidemiological, clinical and microbiological data. Methods After ‐colonised patient was diagnosed a COVID‐19 ICU at hospital Salvador, multidisciplinary team conducted local C . prevalence investigation. Screening cultures for were collected from patients, healthcare workers inanimate surfaces. Risk factors colonisation evaluated, fungemia episodes that occurred after investigation also analysed...
To provide species distribution and antifungal susceptibility profiles of 358 Trichosporon clinical isolates collected from 24 tertiary-care hospitals.Species identification was performed by sequencing the IGS1 region rDNA. Antifungal testing for amphotericin B, fluconazole, voriconazole posaconazole followed Clinical Laboratory Standards Institute reference method. Tentative epidemiologic cutoff values (97.5% ECVs) antifungals asahii were also calculated.Isolates cultured mostly urine...
Candidemia has been considered a persistent public health problem with great impact on hospital costs and high mortality. We aimed to evaluate the epidemiology prognostic factors of candidemia in tertiary Northeast Brazil from January 2011 December 2016. Demographic clinical data patients were retrospectively obtained medical records antifungal susceptibility profiling was performed using broth microdilution method. A total 68 episodes evaluated. found an average incidence 2.23 /1000...
Several studies have been developed regarding human health risks associated with the recreational use of beaches contaminated domestic sewage. These wastes contain various micro-organisms, including Candida tropicalis. In this context, objective study was to characterize C. tropicalis isolates from sandy beach Ponta Negra, Natal, Rio Grande do Norte, Brazil, expression in vitro virulence factors, adaptation osmotic stress and susceptibility antifungal drugs. We analyzed 62 environmental...
Abstract Background Trichosporon fungaemia (TF) episodes have increased in recent years and mortality rates remain high despite the advances management of sepsis. New concepts about its clinical course, treatment microbiology need to be investigated for better this infection. Objectives To describe aetiology, natural history, prognostic factors TF. Methods TF documented between 2005 2018 23 South American centres were retrospectively by using a standard form. Molecular identification,...
To investigate the occurrence of Trichosporon asahii fungemia among critically ill COVID-19 patients.From 1 July to 30 September 2020, cases T (TAF) in a Brazilian referral centre were investigated. The epidemiology and clinical courses detailed, along with mycological investigation that included molecular species identification, haplotype diversity analysis antifungal susceptibility testing.Five patients developed TAF period. All five had common risk conditions for TAF: central venous...
<title>Abstract</title> <italic>Trichosporon austroamericanum</italic> is a recently described species recognized for its emerging clinical significance in invasive trichosporonosis. In this study, we present the nanopore long-read-based <italic>de novo</italic> genome assembly of type-strain CBS 17435. Additionally, performed genomic comparative analyses with closest relative, inkin</italic>.
Trichosporon spp. are emerging pathogens that may cause high mortality rates, specifically among immunocompromised individuals. The objectives of this study were to perform a phylogenetic analysis clinical isolates. We also evaluated the expression different virulence factors in vitro. In addition, isolates grown presence cell-wall and membrane stressors. antifungal susceptibility profiling was determined. most prevalent strains belonged recently described species T. austroamericanum, with...
Trichosporon species are relevant etiologic agents of hospital-acquired infections. High mortality rates attributed to deep-seated infections in immunocompromised individuals, making fast and accurate identification for hastening the discovery best-targeted therapy. Recently, taxonomy has been reassessed, three genera have proposed pathogenic species: Trichosporon, Cutaneotrichosporon, Apiotrichum Matrix-assisted laser desorption ionization-time flight mass spectrometry (MALDI-TOF MS)...
There is worldwide concern with the increasing rates of infections due to multiresistant Candida isolates reported in tertiary medical centers. We checked for historical trends terms prevalence and antifungal susceptibility haemulonii species complex our yeast stock culture collected during last 11 years. The were identified by sequencing rDNA internal transcribed spacer (ITS) region, tests amphotericin B, voriconazole, fluconazole, anidulafungin, 5-fluorocytosine performed Clinical...
Abstract During an epidemiological survey, a potential novel species within the basidiomycetous yeast genus Trichosporon was observed. The clinical strain obtained from urine sample taken Brazilian kidney transplant recipient. molecularly identified using intergenic spacer (IGS1) ribosomal DNA locus and subsequent phylogenetic analysis showed that multiple strains were previously reported by other studies shared identical IGS1-genotype most closely related to of inkin . However, none these...
The aim of this study was to identify Candida species isolated from women diagnosed with recurrent vulvovaginal candidiasis (RVVC) and their partners; evaluate the fluconazole (FLZ) susceptibility isolates. In a period six years, among 172 patients candidiasis, 13 that presented RVVC partners were selected for investigation. isolates obtained using Chromagar medium, identification performed by phenotypic molecular methods FLZ evaluated E-test. Among 26 strains we identified 14 albicans,...
Trichosporon asahii is an opportunistic fungal pathogen that can cause severe infections with high mortality rates. Azole derivatives are the best-targeted therapy for T. invasive infections, but azole-resistant isolates have been reported.
We report the first two cases of Trichosporon mycotoxinivorans infections in Latin America. also conducted a literature review and microbiological investigation, including that clinical environmental isolates. A 30-year-old man with chronic renal failure had disseminated infection after dialysis 15-year-old boy cystic fibrosis (CF) pulmonary exacerbations positive respiratory samples. relevant revealed deep-seated were related to immunosuppression or invasive devices, while most CF patients...
Candida spp. has been reported as one of the common agents nosocomial bloodstream infections and is associated with a high mortality. Therefore, this study evaluated clinical findings, local epidemiology, microbiological aspects candidemia in eight tertiary medical centers state Parana, South Brazil. In study, we 100 episodes patients admitted to different hospitals five cities Brazil, using data collected locally (2016 2017) tabulated online. The incidence was found be 2.7 / 1000 day 1.2...