A5057662865- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Bacterial Infections and Vaccines
- Emergency and Acute Care Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Streptococcal Infections and Treatments
- Influenza Virus Research Studies
- Mosquito-borne diseases and control
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Antibiotic Use and Resistance
- Pleural and Pulmonary Diseases
- Antibiotics Pharmacokinetics and Efficacy
- Neonatal and fetal brain pathology
- Viral gastroenteritis research and epidemiology
- Nosocomial Infections in ICU
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Pediatric health and respiratory diseases
- Child and Adolescent Health
- Vaccine Coverage and Hesitancy
- Antimicrobial Resistance in Staphylococcus
- Virology and Viral Diseases
- Infective Endocarditis Diagnosis and Management
- Ultrasound in Clinical Applications
Universidade Federal da Bahia
2016-2025
Respiratory and Meningeal Pathogens Research Unit
2014-2016
University of the Witwatersrand
2014-2016
Fundação Oswaldo Cruz
2010-2016
National Council for Scientific and Technological Development
2015-2016
Turku University Hospital
2015-2016
Vienna Biocenter
2016
Valneva (Austria)
2016
Finnish Institute for Health and Welfare
2016
Fundação de Amparo à Pesquisa do Estado da Bahia
2016
We report an investigation for 16 bacteria and viruses among 184 children hospitalized with pneumonia in Salvador, Brazil. Etiology was established 144 (78%) cases. Viral, bacterial, mixed infections were found 110 (60%), 77 (42%), 52 (28%) patients, respectively. Rhinovirus (21%) Streptococcus pneumoniae the most common pathogens. Our results demonstrate importance of viral pneumococcal those patients.
Data on the prevalence of pneumococcal nasopharyngeal carriage and its risk factors among adolescents are scarce. The aim this study was to provide such information. A cross-sectional, population-based prospective conducted. Participants were 1013 (age range 10-19 years) randomly recruited in 22 public schools. Those schools chosen 307 from 11 Sanitary Districts Salvador, Brazil. Nasopharyngeal samples assessed by standard procedures recover identify Streptococcus pneumoniae. potential...
<h3>Objective:</h3> To determine whether the presence of in vitro penicillin-resistant <i>Streptococcus pneumoniae</i> increases risk clinical failure children hospitalised with severe pneumonia and treated penicillin/ampicillin. <h3>Design:</h3> Multicentre, prospective, observational study. <h3>Setting:</h3> 12 tertiary-care centres three countries Latin America. <h3>Patients:</h3> 240 aged 3–59 months, known susceptibility <i>S pneumoniae</i>. <h3>Intervention:</h3> Patients were...
<h3>Objective</h3> To examine the ability of criteria proposed by WHO to identify pneumonia among cases presenting with wheezing and extent which adding fever alters their performance. <h3>Design</h3> Prospective classification 390 children aged 2–59 months lower respiratory tract disease into five diagnostic categories, including pneumonia. for identification a set such modified were compared radiographically diagnosed as gold standard. <h3>Results</h3> The sensitivity was 94% <24 62%...
Community-acquired pneumonia (CAP) is a common cause of morbidity among children. Evidence on seasonality, especially the frequency viral and bacterial causative agents scarce; such information may be useful in an era changing climate conditions worldwide. To analyze distinct infections, meteorological indicators seasons children hospitalized for CAP Salvador, Brazil, nasopharyngeal aspirate blood were collected from 184 patients aged <5 y over 21-month period. Fourteen microbes investigated...
Abstract Human bocavirus (HBoV) is a human virus associated with respiratory disease in children. Limited information available on acute infection HBoV among children admitted to hospital community‐acquired pneumonia tropical regions and the current diagnosis inadequate. The aims were diagnose describe infections hospitalized for pneumonia. In Salvador, Brazil, 277 prospectively enrolled. Paired serum samples tested by IgG, IgM, IgG‐avidity enzyme immunoassays (EIAs) using recombinant VP2....
Zika virus (ZIKV) infection appeared in Brazil 2015, causing an epidemic outbreak with increased rates of microcephaly and other serious birth disorders. We reviewed 102 cases children who were diagnosed at had gestational exposure to ZIKV during the outbreak. describe clinical, neuroimaging, neurophysiological findings. Most mothers (81%) reported symptoms infection, especially cutaneous rash, first trimester pregnancy. The was severe 54.9% cases. All infants presented brain malformations....
Abstract Human bocavirus 1 (HBoV1) causes mild to life-threatening respiratory tract infections (RTI) in children but may persist the airways for months. The currently used PCR thus lead false diagnoses and irrelevant co-detections. Our aim was differentiate acute from persistent shedding by pretreatment of airway or serum samples with an endonuclease followed (ePCR). We show that HBoV1 DNA is protected a capsid phase not shedding, provide proof-of-concept novel test be applied routine...
Empirical antibiotic use is prescribed in managing children with pneumonia worldwide. We assessed the usefulness of procalcitonin (PCT) and interferon-alpha (IFN-α) differentiating viral from bacterial pneumonia. Among 159 hospitalized children, was diagnosed based on clinical complaints plus pulmonary infiltrate. Aetiology investigated for 9 viruses 4 atypical 3 typical bacteria. PCT IFN-α were measured serum sample collected admission. Eight patients had bacteraemic infections, 38...
Abstract This study assessed the inter‐observer agreement in interpretation of several radiographic features chest radiographs (CXR) 803 children aged 2–59 months with non‐severe acute lower respiratory tract infection (ALRI). Inclusion criteria comprised: report complaints, detection findings, and presence pulmonary infiltrate on CXR taken admission read by pediatrician duty. Data demographic clinical findings were collected from included a trial use amoxicillin (ClinicalTrials.gov...
The role of chest radiograph (CXR) among children with community-acquired pneumonia is controversial. We aimed to assess if there association between a specific etiology and radiologically confirmed pneumonia.This was prospective cross-sectional study. Based on report respiratory complaints fever/difficulty breathing plus the detection pulmonary infiltrate/pleural effusion CXR taken upon admission read by pediatrician duty, <5-year-old hospitalized were enrolled. On admission, clinical data...
ABSTRACT: Objective: To assess the gross motor development of children with presumed congenital Zika virus (ZIKV) infection over first 2 years their lives. Methods: Seventy-seven were assessed at median ages 11, 18, and 24 months, using evaluative instrument Gross Motor Function Measure (GMFM-66). At third assessment, diagnoses cerebral palsy (CP) classified by severity through Classification System (GMFCS) stratified topography indicating predominantly affected limbs. With these instruments...
To provide cutting‐edge information for the management of community‐acquired pneumonia in children under 5 years, based on latest evidence published literature. A comprehensive search was conducted PubMed, by using expressions: "community‐acquired pneumonia" AND "child" "etiology" OR "diagnosis" "severity" "antibiotic". All articles retrieved had title and abstract read, when papers reporting each subject were identified downloaded complete reading. In era largely implemented bacterial...
In 2010, Brazil introduced the ten-valent pneumococcal conjugate vaccine (PCV10) in national infant immunization program. Limited data on long-term impact of PCV10 are available from lower-middle-income settings. We examined invasive disease (IPD) Salvador, Bahia, over 11 years. Prospective laboratory-based surveillance for IPD was carried out 9 hospitals metropolitan region Salvador 2008 to 2018. defined as Streptococcus pneumoniae cultured a normally sterile site. Serotype determined by...
Pneumonia is an important cause of morbidity and mortality among children throughout the world. Vaccines are available for some organisms, but they underutilized and/or still in development. To evaluate potential impact vaccines, we review studies which etiology childhood community-acquired pneumonia was recorded. In North America Europe (9 studies), established 62% studied (range 43%-88%) by use noninvasive specific methods microbiologic diagnosis. The most often identified agents were S....
Oral amoxicillin (50 mg/kg/day) thrice daily is the first-line therapy for non-severe childhood pneumonia. Compliance could be enhanced if two doses are employed. We assessed equivalence of oral or twice in those patients. This randomized (1 : 1), controlled, triple-blinded investigation conducted at one centre Brazil included children aged 2–59 months with pneumonia diagnosed by trained paediatricians based on respiratory complaints and radiographic pulmonary infiltrate/consolidation....
The comparison of the frequencies bacterial and viral infections among children with community-acquired pneumonia (CAP) admitted in distinct severity categories, an original study, is lacking literature to-date. We aimed to achieve this goal.Children aged 2-59-months-old hospitalized CAP were included prospective study Salvador, Brazil. Clinical data biological samples collected investigate 11 viruses 8 bacteria. Severity was assessed by using World Health Organization criteria.One hundred...
OBJETIVO: Padronizar o uso dos antibióticos no tratamento das crianças e adolescentes com pneumonia comunitária Brasil. MÉTODOS: Foram utilizados os dados bases de Medline Literatura Latino-Americana do Caribe em Ciências da Saúde (LILACS); documentos Organização Mundial Pan-Americana Saúde, 1980 a 2002; busca na Internet, português, espanhol inglês, utilizando-se as palavras-chave "pneumonia, criança, adolescente, etiologia, tratamento"; questionamentos pesquisadores reconhecido saber sobre...