A5080113475- Research in Social Sciences
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Bacterial Infections and Vaccines
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- NF-κB Signaling Pathways
- Genomics, phytochemicals, and oxidative stress
- Cancer Research and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Probiotics and Fermented Foods
- Lung Cancer Research Studies
- Tryptophan and brain disorders
- Meat and Animal Product Quality
- Neuroinflammation and Neurodegeneration Mechanisms
- Digestive system and related health
- Vitamin D Research Studies
- Advanced Chemical Sensor Technologies
- Contemporary Literature and Criticism
- Comics and Graphic Narratives
- Subtitles and Audiovisual Media
- Narrative Theory and Analysis
- Social Work Education and Practice
University of Helsinki
1983-2025
University of Eastern Finland
2023-2024
Finnish Institute for Health and Welfare
2015
National Institutes of Health
2014
Valio (Finland)
2005
Rockefeller University
1990
Finnish Defence Forces
1983
The Kelch-like ECH-associated protein 1 (KEAP1) - Nuclear factor erythroid 2 -related (NRF2) pathway is the major transcriptional stress response system in cells against oxidative and electrophilic stress. NRF2 frequently constitutively active many cancers, rendering resistant to chemo- radiotherapy. Loss-of-function (LOF) mutations repressor KEAP1 are common non-small cell lung cancer, particularly adenocarcinoma. While can occur throughout gene, they enriched certain areas, indicating that...
Abstract Immunotherapy has transformed cancer treatment, offering promising outcomes even in previously incurable cancers. However, responses to immuno-oncology (IO) treatments remain limited, with only a fraction of patients benefiting from these therapies. This limited efficacy arises lack predictive biomarkers, unknown mechanisms immune resistance, and the complex tumor-immune interactions, making it challenging predict which will benefit costly treatments. To address issues, we developed...
First-episode psychosis (FEP) is associated with inflammatory and brain structural changes, but few studies have investigated whether systemic inflammation associates changes in FEP. Thirty-seven FEP patients (median 27 days on antipsychotic medication), 19 matched controls were recruited. Serum levels of 38 chemokines cytokines, cardiovascular risk markers measured at baseline 2 months later. We collected T1- diffusion-weighted MRIs a 3 T scanner from the baseline. analyzed association...
Selective late-onset hypolactasia (lactose malabsorption) was examined in a fixed cohort of Finnish adolescents, now aged 17 to 25 years. This the third examination same subjects. In first 10 years ago prevalence 6.2%. second 5 three more cases were diagnosed, and 9.3%. this 10.3% (10/97); 2 newly manifested diagnosed. If those subjects included who not time but whose diagnosed previously or at least 20 old examination, 12.7% (13/102). 17- 20-year-olds 15.4%, 21- 25-year-olds it 11.1%. The...
Despite immunotherapy’s promise in cancer treatment, patient responses vary substantially because of the individual nature immune system and lack reliable biomarkers. To address this issue, we developed a precision ex vivo platform that integrates patient-specific tumor cells to study mechanisms antitumor response, predict immunotherapy outcomes, identify effective treatments. This revealed unique single-cell response sensitivities standard-of-care immunotherapies. Furthermore, were able...
An experimental system which allows the selective reisolation and structural analysis of a newly made (nascent) segment pneumococcal peptidoglycan at various times after its incorporation into preexisting old cell wall was developed. Age-related changes were observed in each one major nine peptide components resolvable by high-performance liquid chromatography method. The nascent (made 1.7% generation time) contained 60% peptides as alanyl-isoglutamyl-lysine tripeptide monomer, 12% directly...
Monessa oppilaitoksessa on huolestuttu yhteisöllisyyden heikkenemisestä ja sitä halutaan vahvistaa erilaisin toimenpitein. Tällä tavoitellaan myönteisiä vaikutuksia yksilöille, lähiyhteisöille organisaatioille. Tässä artikkelissa tarkastelemme yhteisöllisyyttä oppilaitoksissa pedagogisen hyvinvoinnin näkökulmasta kahdessa valmennuspilotissa, joista toinen toteutettiin ammatillisessa koulutuksessa korkeakoulukentällä. Pedagoginen hyvinvointi käsitteenä antaa oppilaitosyhteisöille välineen...
Abstract The Kelch-like ECH-associated protein 1 (KEAP1) – Nuclear factor erythroid 2-related 2 (NRF2) pathway is the major transcriptional stress response system in cells against oxidative and electrophilic stress. NRF2 frequently constitutively active many cancers, rendering resistant to chemo- radiotherapy. Loss-of-function (LOF) mutations repressor KEAP1 are common non-small cell lung cancer, particularly adenocarcinoma. While can occur throughout gene, they enriched certain areas,...
i n e Väitöstutkimukseni aiheena on epäröinti ja sen ilmeneminen vuorovaikutuksessa.Tutkin, miten ilmenee venäläisissä televisiokeskusteluissa vaikkapa, kun ihminen miettii sopivan ilmauksen valintaa tai suunnittelee tulevaa puheensa sisältöä rakennetta.Puhe ajassa lineaarisesti askel