A5001075589- Genomics, phytochemicals, and oxidative stress
- Eicosanoids and Hypertension Pharmacology
- Nitric Oxide and Endothelin Effects
- Glutathione Transferases and Polymorphisms
- Sulfur Compounds in Biology
- Heme Oxygenase-1 and Carbon Monoxide
- Peroxisome Proliferator-Activated Receptors
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Redox biology and oxidative stress
- Free Radicals and Antioxidants
- Circular RNAs in diseases
- Inflammatory mediators and NSAID effects
- Atherosclerosis and Cardiovascular Diseases
- Retinal Diseases and Treatments
- Lung Cancer Treatments and Mutations
- Antioxidant Activity and Oxidative Stress
- Cholesterol and Lipid Metabolism
- Effects and risks of endocrine disrupting chemicals
- Cancer Research and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Adenosine and Purinergic Signaling
- Adipose Tissue and Metabolism
- Virus-based gene therapy research
- Alcohol Consumption and Health Effects
University of Eastern Finland
2016-2025
Finland University
2010-2022
American Nephrology Nurses Association
2012-2013
Kuopio University Hospital
2007-2012
Tohoku University
2008-2010
University of Oulu
2010
Institute for Molecular Science
2008
Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA)
2008
Medical University of Vienna
2008
Amsterdam UMC Location University of Amsterdam
2008
The molecular mechanisms through which oxidized lipids and their electrophilic decomposition products mediate redox cell signalling is not well understood may involve direct modification of signal-transduction proteins or the secondary production reactive oxygen nitrogen species in cell. Critical adaptation cells to oxidative stress, including exposure subtoxic concentrations lipids, transcriptional regulation antioxidant enzymes, many are controlled by antioxidant-responsive elements...
The amyloid hypothesis of Alzheimer's disease (AD) postulates that amyloid-β (Aβ) deposition and neurotoxicity play a causative role in AD; oxidative injury is thought to be central the pathogenesis. An endogenous defense system against stress induced by binding transcription factor nuclear E2-related 2 (Nrf2) antioxidant response element (ARE) enhancer sequence. Nrf2-ARE pathway activated reactive oxygen species trigger simultaneous expression numerous protective enzymes scavengers. To...
Nitro-fatty acids (NO2-FAs) are electrophilic signaling mediators formed in vivo via nitric oxide (NO)- and nitrite (NO2−)-dependent reactions. modulate cascades reversible covalent post-translational modification of nucleophilic amino regulatory proteins enzymes, thus altering downstream events, such as Keap1-Nrf2-antioxidant response element (ARE)-regulated gene expression. In this study, we investigate the molecular mechanisms by which 9- 10-nitro-octadec-9-enoic acid (OA-NO2) activate...
Objective— Atheroprotective blood flow induces expression of anti-inflammatory Krüppel-like factor 2 (KLF2) and activates antioxidant transcription nuclear erythroid 2-related (Nrf2) in vascular endothelium. Previously, we obtained KLF2-induced gene profiles ECs, containing several Nrf2 target genes. Our aim was to investigate the role KLF2 shear stress–mediated activation human umbilical vein endothelial cells (HUVECs). Methods Results— Expression its targets NAD(P)H dehydrogenase quinone...
Reactive oxygen species (ROS) play a major role in vascular inflammation and pathophysiology of many diseases such as atherosclerosis injury-induced neointima formation after balloon angioplasty. Nuclear factor E2-related factor-2 (Nrf2) is transcription orchestrating antioxidant cytoprotective responses on oxidative electrophilic stress, it has been shown to have antiinflammatory effects cells vitro. We therefore postulated that Nrf2 gene transfer would salutary angioplasty.Transduction...
Electrophilic fatty acid derivatives, including nitrolinoleic and nitro-oleic (OA-NO2), can mediate anti-inflammatory pro-survival signaling reactions. The transcription factor Nrf2, activated by electrophilic acids, suppresses redox-sensitive pro-inflammatory gene expression protects against vascular endothelial oxidative injury. It was therefore postulated that activation of Nrf2 OA-NO2 accounts in part for its actions, motivating the characterization Nrf2-dependent -independent effects on...
Besides their well-characterized proinflammatory and proatherogenic effects, oxidized phospholipids, such as oxPAPC (oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-phosphocholine) have been shown to beneficial responses in vascular cells via induction of antioxidant enzymes heme oxygenase-1. We therefore hypothesized that could evoke a general cytoprotective response activation antioxidative transcription factor Nrf2. Here, we show increases nuclear accumulation Using the small interfering...
Age-related macular degeneration (AMD) is a multi-factorial disease that the leading cause of irreversible and severe vision loss in developed countries. It has been suggested pathogenesis dry AMD involves impaired protein degradation retinal pigment epithelial cells (RPE). RPE are constantly exposed to oxidative stress may lead accumulation damaged cellular proteins, DNA lipids evoke tissue deterioration during aging process. The ubiquitin-proteasome pathway lysosomal/autophagosomal two...
Neural stem/progenitor cells (NPCs) proliferate and produce new neurons in neurogenic areas throughout the lifetime. While these represent potential therapeutic treatment of neurodegenerative diseases, regulation neurogenesis is not completely understood. We show that deficiency nuclear factor erythroid 2-related (Nrf2), a transcription induced response to oxidative stress, prevents ischemia-induced increase newborn subgranular zone dentate gyrus. Consistent with this finding, growth NPC...
The NRF2 pathway is frequently activated in various cancer types, yet a comprehensive analysis of its effects across different malignancies currently lacking. We developed activity metric and utilized it to conduct pan-cancer oncogenic signaling. identified an immunoevasive phenotype where high associated with low interferon-gamma (IFNγ), HLA-I expression T cell macrophage infiltration squamous the lung, head neck area, cervix esophagus. Squamous overactive tumors comprise molecular...
Numerous electrophilic metabolites are formed during cellular activity, particularly under conditions of oxidative, inflammatory and metabolic stress. Among them lipid oxidation nitration products, compounds derived from amino acid central carbon metabolism. Here we focus on one target electrophiles, the Kelch-like ECH associated protein 1 (KEAP1)/nuclear factor erythroid 2 p45-related (NRF2) partnership. Many these reactive modify C151, C273 and/or C288 within KEAP1. Other types...
The Kelch-like ECH-associated protein 1 (KEAP1) - Nuclear factor erythroid 2 -related (NRF2) pathway is the major transcriptional stress response system in cells against oxidative and electrophilic stress. NRF2 frequently constitutively active many cancers, rendering resistant to chemo- radiotherapy. Loss-of-function (LOF) mutations repressor KEAP1 are common non-small cell lung cancer, particularly adenocarcinoma. While can occur throughout gene, they enriched certain areas, indicating that...