A5040856325- Seismic Imaging and Inversion Techniques
- Seismic Waves and Analysis
- Seismology and Earthquake Studies
- Geophysical Methods and Applications
- Geophysics and Sensor Technology
- Geophysical and Geoelectrical Methods
- earthquake and tectonic studies
- Drilling and Well Engineering
- Geological Modeling and Analysis
- Geochemistry and Geologic Mapping
- Earthquake Detection and Analysis
- Methane Hydrates and Related Phenomena
- High-pressure geophysics and materials
- Geological and Geochemical Analysis
- Hydraulic Fracturing and Reservoir Analysis
- Geological and Geophysical Studies
- Angiogenesis and VEGF in Cancer
- Reservoir Engineering and Simulation Methods
- Geological Studies and Exploration
- Atomic and Subatomic Physics Research
- Lymphatic System and Diseases
- Congenital heart defects research
- Geomagnetism and Paleomagnetism Studies
- Genomics, phytochemicals, and oxidative stress
- RNA Interference and Gene Delivery
University of Helsinki
2009-2025
Institute of Seismology
2024-2025
Geological Survey of Finland
2016-2025
University of Eastern Finland
2008-2013
Kuopio University Hospital
2008-2011
Ark Therapeutic (United States)
2009
University of California, San Diego
2009
Institute for Molecular Science
2008
Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA)
2008
Medical University of Vienna
2008
Besides their well-characterized proinflammatory and proatherogenic effects, oxidized phospholipids, such as oxPAPC (oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-phosphocholine) have been shown to beneficial responses in vascular cells via induction of antioxidant enzymes heme oxygenase-1. We therefore hypothesized that could evoke a general cytoprotective response activation antioxidative transcription factor Nrf2. Here, we show increases nuclear accumulation Using the small interfering...
We studied a possibility that shRNAs can lead to transcriptional gene activation at the promoter level via epigenetic mechanism.The purpose of this study was test effects on vascular endothelial growth factor (VEGF-A) expression by targeted small hairpin RNAs (shRNAs) in vitro and experimental animals vivo using stable local lentiviral transfer.One shRNA identified which strongly increased VEGF-A C166 cells mRNA protein whereas another decreased expression. Quantitative chromatin...
AimsThe loss of nuclear factor E2-related 2 (Nrf2) has been shown to protect against atherogenesis in apoE-deficient mice. The mechanism by which Nrf2 deficiency affords atheroprotection this model is currently unknown, but combined systemic and local vascular effects on lesion macrophages have proposed. We investigated the effect bone marrow-specific early low-density lipoprotein (LDL) receptor-deficient (LDLR−/−) mice, assessed cellular accumulation modified LDLs expression inflammatory...
We show that by using an advanced pre-stack depth imaging algorithm it is possible to retrieve meaningful and robust seismic images with sparse shot points, only 3–4 source points per kilometer along a profile. Our results encourage the use of 2D reflection profiling as reconnaissance tool for mineral exploration in areas limited access active surveys. used data acquired within COGITO-MIN project comprising two approximately 6 km long profiles at polymetallic Kylylahti massive sulfide mine...
A 10.5 km2 3D seismic survey was acquired over the Kylylahti mine area (Outokumpu mineral district, eastern Finland) as a part of COGITO-MIN (COst-effective Geophysical Imaging Techniques for supporting Ongoing MINeral exploration in Europe) project, which aimed at development cost-effective geophysical imaging methods exploration. The cost-effectiveness our case related to fact that an active-source accomplished by using receiver spread originally designed passive survey. array recorded...
Summary The XSoDEx (eXperiment of Sodankylä Deep Exploration) project acquired in total 82 km seismic reflection and refraction data to improve the understanding crustal composition and, consequently, mineral systems region Northern Finland. is part Central Lapland Greenstone belt, which famous for its resources. Here, we present first subsurface images resulting from processing, provide geological interpretation data. Our workflow comprised time domain signal migration velocity model...
Abstract. The Seismic and Electromagnetics Methods for Deep mineral exploration (SEEMS DEEP) project is associated with the Koillismaa Layered Igneous Complex (KLIC) in north-eastern Finland. KLIC characterized by a Bouguer positive gravity magnetic anomaly zone connecting two exposed ends of i.e. intrusion Näränkävaara intrusion. has potential to host several critical raw minerals, like nickel cobalt which are included European Union’s material list. For this purpose, regional seismic...
   Seismic imaging has traditionally been applied to far-field signals using earthquake tomography and, in more recent decades, ambient noise tomography. However, with modern large-N seismic arrays it demonstrated that structural observations at sub-wavelength distances are possible utilizing the surface wave focal spot method. The is zero-lag correlation amplitude field derived from dense array correlations. One advantage compared ability analyze waves length scales large...
We report on establishing the mobile Finnish Seismic Instrument Pool (FINNSIP) that is owned and operated by academic research institutions. The pool supports domestic international collaborative seismic research. At conclusion of 2020 to 2024 build-up stage, instrumentation includes 46 broadband seismometers digitizers, 5 accelerometers, 1216 71 Geospace SmartSolo autonomous geophone units, respectively, making FINNSIP one largest most coherent instrument pools in Europe public sector....
Vascular endothelial growth factors (VEGFs) and their receptors (VEGF-Rs) are among the most powerful regulating vascular growth. However, it has remained unknown whether stimulation of VEGF-R1, VEGF-R2 or both produces best angiogenic responses in myocardium. The aim this study was to compare VEGF-R1-specific ligand VEGF-B186, VEGF-R2-specific VEGF-E VEGF-A165, which stimulates receptors, regarding effects on angiogenesis left ventricular function mice. High-resolution echocardiography used...
In 2007, a 2D reflection seismic survey was conducted at the Kevitsa Ni-Cu-PGE (platinum group elements) deposit in northern Finland. The aims of were to delineate overall extent ore-bearing ultramafic intrusive complex, study response disseminated ore deposit, potentially find indications for new deposits, and extract structural information depth that may be associated with mineralization. processing sequence, specific focus given finding optimal CDP-line geometries crooked-line profiles...
Objective— The mature form of human vascular endothelial growth factor-D (hVEGF-D ΔNΔC ) is an efficient angiogenic factor, but its full mechanism action has remained unclear. We studied the effects hVEGF-D in cells using gene array, signaling, cell culture, and vivo transfer techniques. Methods Results— Concomitant with proliferative responses, enhanced phosphorylation VEGF receptor-2, Akt, nitric oxide synthase. Gene arrays, quantitative reverse transcription–polymerase chain reaction,...
We tested the applicability of a newly developed broadband (0–800 Hz) digital-based seismic landstreamer for open-pit mine planning in apatite-bearing Siilinjärvi central Finland. Four profiles, total approximately 2.5 km long (2–4 m source and receiver spacing), two inside pit on its margins, were acquired combination with wireless recorders connected to 10 Hz geophones fixed at every spacing along profiles while streamer data being acquired. Downhole logging laboratory physical property...
The main issues related to passive-source reflection imaging with seismic interferometry (SI) are inadequate acquisition parameters for sufficient spatial wavefield sampling and vulnerability of surface arrays the dominant influence omnipresent surface-wave sources. Additionally, long recordings provide large data volumes that require robust efficient processing methods. We address these problems by developing a two-step evaluation event detection (TWEED) method body waves in recorded...
In the Pyhäsalmi case study, seismic data is used in direct targeting of shallowly dipping mineralized zones a massive sulfide ore system that was deformed complex fold interference structures under high-grade metamorphic conditions. The volcanic-hosted (VHMS) deposit ([Formula: see text]) located Proterozoic volcanic belt central Finland. Acoustic impedance distinct from host rocks text]), enabling its detection with reflection methods. Drill-hole logging further indicates imaging contact...
Seismic reflection data was applied to a study of the upper crustal structures in Outokumpu mining and exploration area eastern Finland. The Cu-Co-Zn sulfide ore deposits are hosted by Palaeoproterozoic ophiolite-derived altered ultrabasic rocks (serpentinite, skarn rock, quartz rock) black schist within turbiditic mica schist. Mining has produced total 36 Mt from three historical one active mine. comprises 2D vibroseis surveyed along network local roads. seismic sections provide...
ABSTRACT A traveltime inversion technique is applied to model the upper ∼40 m of subsurface a glaciated shield rock area in order calculate static corrections for multi‐azimuth multi‐depth walk‐away vertical seismic profile and surface reflection profile. First break information from refraction survey used conjunction with ray‐tracing program an iterative damped least‐squares algorithm create two‐dimensional subsurface. The layout required crooked lines substantial gaps source receiver...
Summary We present the results of adapting seismic interferometry (SI) for reflection imaging in mineral exploration. use a unique dataset one-month ambient-noise recordings acquired with large-N array (~1000 receivers) deployed regular grid (50 m receiver interval, 200 line interval) directly above known mineralisation and underground mine infrastructure at Kylylahti polymetallic located Eastern Finland. Ambient-noise study area is dominated by road traffic activities (both surface...