A5037404963- Advanced Radiotherapy Techniques
- Breast Cancer Treatment Studies
- Ultrasound Imaging and Elastography
- Advances in Oncology and Radiotherapy
- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Radiation Therapy and Dosimetry
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Diagnosis and Treatment
- Microwave Engineering and Waveguides
- Prostate Cancer Treatment and Research
- Medical Imaging Techniques and Applications
- Ultrasonics and Acoustic Wave Propagation
- Millimeter-Wave Propagation and Modeling
- Lung Cancer Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Brain Metastases and Treatment
- Nanoplatforms for cancer theranostics
- Antenna Design and Optimization
- Effects of Radiation Exposure
- Breast Implant and Reconstruction
- Real-time simulation and control systems
- Peroxisome Proliferator-Activated Receptors
- Genomics, phytochemicals, and oxidative stress
- Innovative Energy Harvesting Technologies
Kuopio University Hospital
2010-2024
Leeds Teaching Hospitals NHS Trust
2013
University of Eastern Finland
2005-2010
Sunnybrook Health Science Centre
2006-2009
Brigham and Women's Hospital
2006
Harvard University
2006
University of Toronto
2006
The aim of the present study was to introduce a new restricted tangential volumetric modulated arc therapy (tVMAT) technique for whole breast irradiation and compare its dosimetric properties other currently used cancer radiotherapy techniques.Ten consecutive women with left-sided were enrolled in this retrospective study. Four treatment plans generated each patient: 1) standard field-in-field (FinF), 2) intensity (tIMRT), 3) VMAT two dual arcs 50-60° 4) continuous (cVMAT) 240°. created...
Macrophage scavenger receptor A (SR-A) and class B CD36 (CD36) contribute to foam cell formation atherogenesis via uptake of modified lipoproteins. So far, the role these receptors has been studied mainly using knockout models totally lacking receptors. We SR-A in by RNA interference (RNAi)-mediated silencing, which is a clinically feasible method down-regulate expression constructed lentivirus vectors encoding short hairpin RNAs (shRNAs) against mouse CD36. Decreased but not led reduced...
AimsThe loss of nuclear factor E2-related 2 (Nrf2) has been shown to protect against atherogenesis in apoE-deficient mice. The mechanism by which Nrf2 deficiency affords atheroprotection this model is currently unknown, but combined systemic and local vascular effects on lesion macrophages have proposed. We investigated the effect bone marrow-specific early low-density lipoprotein (LDL) receptor-deficient (LDLR−/−) mice, assessed cellular accumulation modified LDLs expression inflammatory...
A commercial deep learning (DL)-based automated segmentation tool (AST) for computed tomography (CT) is evaluated accuracy and efficiency gain within prostate cancer patients. Thirty patients from six clinics were reviewed with manual- (MC), automated- (AC) edited (AEC) contouring methods. In the AEC group, created contours (prostate, seminal vesicles, bladder, rectum, femoral heads penile bulb) edited, whereas MC group included empty datasets MC. one clinic, lymph node CTV delineations...
Wireless implantable devices revolutionize the field of biomedical engineering as soon satisfactory power supplies are conceived. This paper presents a novel ultrasound-based method for powering battery-free electrical implant. Contrary to commonly used RF and inductive methods, ultrasonic transmission helps avoid problems with electromagnetic coupling offers use selection data frequencies not limited by national regulations. The proof-of-concept link is based on piezoelectric crystals....
The use of hypofractionated stereotactic body radiotherapy (SBRT) as primary treatment modality in clinically localized prostate cancer (PCa) is emerging, because the low α/β-ratio favors high dose per fraction PCa. There a need for more data about SBRT, especially high-risk PCa patients. purpose this retrospective study was to evaluate safety and short-term efficacy robotic SBRT clinical patient cohort with including also patients (D'Amico risk stratification).A total 240 consecutive were...
Abstract Background The use of stereotactic body radiotherapy (SBRT) as the primary treatment modality in clinically localized prostate cancer (PCa) is emerging. aim study was to analyze long-term results PCa patients treated with SBRT. Methods This non-selected, real-life patient cohort included 213 a robotic SBRT device during 2012–2015. Results median follow-up 64 months (range, 10–85 months), and all risk-groups were represented 47 (22.1%), 56 (26.3%) 110 (51.6%) classified into D’Amico...
Background Several genome-wide association studies have reported a risk locus for coronary artery disease (CAD) in the 9p21. 3 chromosomal region. This region encodes lncRNA INK4 ( ANRIL ) and its genetic variance has strong with CAD, but mechanisms atherogenesis remain unclear. Objectives study aimed to investigate role of murine ortholog human 9p21.3 hypercholesterolemic mice. Methods Murine knockout mice (Chr4 Δ70 kb /Δ70 were crossbred Ldlr −/− ApoB 100/100 mice, atherosclerotic plaque...
This study aimed to determine the geometrical uncertainty of position heart with daily cone beam computed tomography (CBCT) during deep-inspiration breath-hold (DIBH) treatment left breast.A visually guided optical respiratory monitoring system was used in DIBH 15 breast cancer patients. Heart determined relation planning target volume (PTV) 225 fractions which low-dose CBCT images were compared CT images. In addition, lung apex and diaphragm measured evaluate success DIBH.The median shift 1...
In this paper, a computational model for localized harmonic motion (LHM) imaging-based monitoring of high-intensity focused ultrasound surgery (FUS) is presented. The LHM technique based on focused, time-varying radiation force excitation, which induces local oscillatory motions at the focal region. These vibrations are tracked, using pulse-echo imaging, and then, used to estimate mechanical properties sonication feasible FUS because changes in material during coagulation process affect...
Many noninvasive ultrasound techniques have been developed to explore mechanical properties of soft tissues. One these methods, Localized Harmonic Motion Imaging (LHMI), has proposed be used for surgery monitoring. In LHMI, dynamic radiation-force stimulation induces displacements in a target that can measured using pulse-echo imaging and estimate the elastic target. this initial, simulation study, use one-dimensional phased array is explored induction tissue motion. The study compares three...
Cerebral ischemia is a risk factor for Alzheimer's disease (AD). Moreover, recent evidence indicates that it two-way street as the incidence rate of stroke significantly higher in AD patients than those without disease. Here we investigated interaction ischemic brain insults and 9-month-old ApdE9 mice, which show full-blown accumulation Aβ deposits microgliosis brain. Permanent occlusion middle cerebral artery (pMCAo) resulted 36% larger infarct mice compared to their wild-type (wt)...
Purpose: To assess the feasibility of MR-guided soft tissue core biopsies on an open 0.23 T magnet.Material and Methods: Twenty-nine consecutive patients with known or suspected benign malignant tumours underwent MR imaging. A one-slice dynamic enhancement sequence was used to obtain curve tumour. biopsy tumour performed in same session.Results: All could be magnet. Standard images curves were deciding route target. The specimens sufficient for histopathological diagnosis 27 29...
Ray tracing is a widely used approach for deterministic modelling of radio channels. We present our path generation pipeline, which combines environment discretization-based propagation search with refinement, outputs validated paths fulfilling the Fermat's principle least time. propose novel gradient descent-based solution refinement. Whole pipeline implemented as GPU computations using NVIDIA CUDA and OptiX ray engine, experimental results show efficacy approach.
A computational model for local harmonic motion (LHM) imaging‐based monitoring of high‐intensity focused ultrasound surgery (FUS) is presented. LMH technique based on a radiation force excitation, which induces mechanical vibrations at the focal region. These pulse‐echo imaged are then used to estimate properties sonication LHM has been proven be feasible FUS because changes in material during coagulation affect measured displacements. The presented includes separate models simulate acoustic...
Ultrasound-stimulated vibro-acoustography (USVA) is one of the recent noninvasive techniques that have been developed to explore mechanical properties soft tissues. USVA based on interference two focused ultrasound beams a slightly different frequency. This produces time variation acoustic radiation force vibrates joint focal region at difference In this paper, we simulated displacement amplitudes in blood vessel using frequencies and elasticity parameters. The frequency was varied between...
This paper presents a new descriptor for human detection in still images. It is referred to as isotropic granularity-tunable gradients partition (IGGP), which extended from (GGP) descriptors. The representation achieved by aligning the features with different orientation channels according their principal angles. benefits of this extension are two folds: firstly, since partitions’ sizes all equal, noise introduce small partitions original GGP descriptors eliminated and performance can be...