A5059206058- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal and Macular Surgery
- Ocular Diseases and Behçet’s Syndrome
- Intraocular Surgery and Lenses
- Traumatic Ocular and Foreign Body Injuries
- Ocular Surface and Contact Lens
- Retinal Development and Disorders
- Facial Trauma and Fracture Management
- Ocular Oncology and Treatments
- Ocular Infections and Treatments
- Cerebral Venous Sinus Thrombosis
- Vasculitis and related conditions
- Zebrafish Biomedical Research Applications
- Drug-Induced Ocular Toxicity
- Corneal surgery and disorders
- Neurological Disorders and Treatments
- Long-Term Effects of COVID-19
- Ophthalmology and Eye Disorders
- Dermatologic Treatments and Research
- Sympathectomy and Hyperhidrosis Treatments
- Advanced Glycation End Products research
- Systemic Lupus Erythematosus Research
Medical University of Lublin
2016-2025
Medical University of Warsaw
2023
Jagiellonian University
2023
Górnośląskie Centrum Medyczne
2023
Medical University of Silesia
2023
Collegium Medicum in Bydgoszcz
2022
1 Military Clinical Hospital with Outpatient Clinic
2006-2020
University Clinical Center Tuzla
2018
University of Cologne
2005-2015
Instytut Medycyny Wsi im. Witolda Chodźki
1995-2007
Age-related macular degeneration (AMD) is a multi-factorial disease that the leading cause of irreversible and severe vision loss in developed countries. It has been suggested pathogenesis dry AMD involves impaired protein degradation retinal pigment epithelial cells (RPE). RPE are constantly exposed to oxidative stress may lead accumulation damaged cellular proteins, DNA lipids evoke tissue deterioration during aging process. The ubiquitin-proteasome pathway lysosomal/autophagosomal two...
Background and objectives: We aimed to investigate changes in the radial peripapillary capillary (RPC) network using optical coherence tomography angiography (OCTA) patients who recovered from coronavirus disease 2019 (COVID-19). Materials Methods: This was a prospective study of hospitalized due COVID-19 bilateral pneumonia between March May 2021. The control group included healthy individuals matched for age sex. Two months after discharge, underwent ophthalmological examination, including...
Age-related macular degeneration (AMD) is the main reason for blindness in elderly people developed countries. Current screening protocols have limitations detecting early signs of retinal degeneration. Therefore, it would be desirable to find novel biomarkers detection AMD. Development help prevention, diagnostics, and treatment Proteomic analysis tear film has shown promise this research area. If an optimal set could obtained from accessible body fluids, represent a reliable way monitor...
Abstract MicroRNAs (miRNAs) regulate gene expression; many of them act in the retinal pigment epithelium (RPE), and RPE degeneration is known to be a critical factor age‐related macular (AMD). Repeated injections with anti‐VEGFA (vascular endothelial growth A) are only effective therapy wet AMD. We investigated correlation between expression 18 miRNAs involved regulation VEGFA serum 76 AMD patients 70 controls. Efficacy treatment was evaluated by counting number delivered up 12 years. In...
Aims/Purpose: To evaluate the impact of dry eye disease (DED) on refractive errors in patients after cataract surgery. Methods: Fifty undergoing surgery were studied. Two study groups and a control group distinguished. The first (group A, n = 22, 44%) with preoperatively diagnosed DED who received appropriate treatment (eyelid margin hygiene moisturizing ocular surface). second B, 14, 28%) whom such was also implemented, despite lack diagnosis DED. remaining ( (Group C). Biometric...
Heavy silicone oils are currently under investigation as a permanent tamponade in eyes with inferior PVR. This study was an of Densiron 68 (Fluoron GmbH, Neu-Ulm, Germany) and several new heavy oil admixtures on the basis perfluoroalkanes F4H5 (perfluorobutylpentane), F4H6 (perfluorobutylhexane), F4H8 (perfluorobutyloctane) respect to their long-term tolerance rabbit model.Because better solubility F4Hn-species (n = 5-8) comparison F6H8, we used F4H5, F4H6, generate highly viscous, (HSO)....
In this study, mass spectrometry was used to explore the canine tear proteome. Tear samples were obtained from six healthy dogs, and one-dimensional sodium dodecyl sulphate polyacrylamide gel electrophoresis (1D SDS-PAGE) as a first step separate intact proteins into 17 bands. Each fraction then trypsin digested analysed by matrix-assisted laser desorption/ionization time-of-flight tandem (MALDI-TOF-MS/MS) characterize protein components in each fraction. total, 125 identified, with MCA...
The purpose of this study was to evaluate retinal and choroidal microvascular alterations with optical coherence tomography angiography (OCTA) in COVID-19 patients hospitalized because bilateral pneumonia caused by SARS-CoV-2. vessel density (VD) foveal avascular zone (FAZ) 63 SARS-CoV-2 who had positive polymerase chain reaction (PCR) tests recovered after receiving treatment 45 healthy age- gender-matched controls were evaluated compared using OCTA the superficial capillary plexus (SCP)...
Diabetes is considered an epidemic of the 21st century, and most common microvascular complication, which affects every third patient, diabetic retinopathy. In course retinopathy, endothelial barrier retinal vessels damaged, begins with damage to glycocalyx. Sulodexide rebuilds glycocalyx increases tightness blood-retinal barrier, thereby protecting against caused by hyperglycemia. Its multidirectional mechanism action makes it effective drug in treatment mild moderately advanced...
Purpose.: Tumor necrosis factor alpha (TNF)-α contributes to inflammation-associated angiogenesis. This study investigates the role of TNF-α receptors 1a and 1b in development choroidal neovascularization (CNV). Methods.: CNV was induced Tnfrsf1a−/− Tnfrsf1b−/− mice with C57Bl6/J background their wild-type (WT) (C57Bl/6J) controls by laser damage Bruch's membrane. expression RPE/choroid determined Western blot analysis. Pathologic angiogenesis estimated qualitatively quantitatively...
Trace elements play an important role in the pathogenesis of several serious ophthalmological disorders, such as glaucoma, age-related macular degeneration (AMD), diabetic retinopathy, cataract, etc. This study aimed to measure alterations chemical elements' (67) levels aqueous humor patients undergoing cataract surgery. The pilot included 115 patients, (age 74 ± 7.27, female 64.35%, male 35.65%). were measured by use inductively coupled plasma optical emission spectrometry (ICP-OES),...
The purpose of this study was to evaluate the persistent changes in microvascular parameters based on optical coherence tomography angiography (OCTA) patients hospitalized due COVID-19 bilateral pneumonia. case-control prospective carried out among 49 with and 45 healthy age- gender-matched 2 8 months after hospital discharge. We found a significantly decreased vessel density (VD) superficial capillary plexus (SCP) patients. Significantly (SCP), deep (DCP), choriocapillaris (CC), increased...
The aim of the study was to evaluate incidence ischemic stroke, myocardial infarction, and all-cause mortality in patients with retinal artery occlusion (RAO). This single-center retrospective included 139 diagnosed RAO between 2009 2020. control group age- sex-matched without who underwent cataract surgery. year surgery corresponded onset. During 12-year follow-up, had a shorter time death (49.95 vs. 15.74 months; p = 0.043), higher rate (log-rank 0.026, composite endpoint, including...
Background: Translocation of a free autologous graft consisting retinal pigment epithelium (RPE), Bruch’s membrane, choriocapillaris and choroid in patients with exudative age-related macular degeneration is currently being evaluated clinical practice. Angiographic studies these suggest that their grafts become revascularised. Aim: To investigate the histological evidence revascularisation porcine model. Methods: In 11 pigs (11 eyes), an RPE–choroid was translocated from mid-periphery to...
Macular edema and its further complications due to the leakage from choroidal neovascularization in course of age-related macular degeneration (AMD) is a leading cause blindness among elderly individuals developed countries. Changes tear film proteomic composition have been reported occur various ophthalmic systemic diseases. There an evidence that acute form neovascular AMD may be reflected composition. Tear was collected with Schirmer strips patients sex- age-matched control patients....
Purpose: Retinal artery occlusion (RAO) is associated with an increased risk of cardiovascular events such as ischemic stroke and myocardial infarction, but whether different RAO subtypes central retinal (CRAO) or branch (BRAO) carry similar these unclear. Our aim was to determine the differs between CRAO BRAO. Methods: This single-center, retrospective study included 131 patients hospitalized in our clinic 2010–2020 BRAO confirmed by ophthalmic examination. Data on demographics, previous...
Pathological angiogenesis is correlated with many ophthalmic diseases. The most common are exudative age-related macular degeneration and proliferative diabetic retinopathy. current treatment for these diseases based on regularly administered anti-VEGF antibodies injections. In the study, we investigated selected D2 dopaminergic receptor agonists, namely bromocriptine, cabergoline pergolide, hypoxia-induced neovascularization. We used zebrafish laboratory model, specifically three-day post...
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