A5061304336- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- Diagnosis and treatment of tuberculosis
- Pneumonia and Respiratory Infections
- HIV/AIDS Research and Interventions
- Blood groups and transfusion
- Vitamin D Research Studies
- Machine Learning in Healthcare
- Meningioma and schwannoma management
- RNA modifications and cancer
- Neurofibromatosis and Schwannoma Cases
- Parasites and Host Interactions
- Zoonotic diseases and public health
- Chronic Disease Management Strategies
- HIV Research and Treatment
- Ferroptosis and cancer prognosis
- HIV/AIDS oral health manifestations
- Vascular Malformations Diagnosis and Treatment
- Mosquito-borne diseases and control
- Adipokines, Inflammation, and Metabolic Diseases
- Parasitic Diseases Research and Treatment
- Leprosy Research and Treatment
- Imbalanced Data Classification Techniques
Fundação Oswaldo Cruz
2019-2025
National Education and Research Network
2025
Universidade Salvador
2019-2024
Universidade Federal do Rio de Janeiro
2020-2024
Faculdade de Tecnologia e Ciências
2022-2024
Instituto Evandro Chagas
2023
Vanderbilt University
2023
Universidade Federal do Amazonas
2022
Universidade do Estado do Amazonas
2022
Fundação de Amparo à Pesquisa do Estado da Bahia
2019
Cellular necrosis during Mycobacterium tuberculosis (Mtb) infection promotes both immunopathology and bacterial dissemination. Glutathione peroxidase-4 (Gpx4) is an enzyme that plays a critical role in preventing iron-dependent lipid peroxidation–mediated cell death (ferroptosis), process previously implicated the necrotic pathology seen Mtb-infected mice. Here, we document altered GPX4 expression, glutathione levels, peroxidation patients with active assess of this pathway mice genetically...
Abstract Oxidative stress triggers ferroptosis, a form of cellular necrosis characterized by iron-dependent lipid peroxidation, and has been implicated in Mycobacterium tuberculosis (Mtb) pathogenesis. We investigated whether Bach1, transcription factor that represses multiple antioxidant genes, regulates host resistance to Mtb. found BACH1 expression is associated clinically with active pulmonary tuberculosis. Bach1 deletion Mtb-infected mice increased glutathione levels Gpx4 inhibit...
Abstract Background Diagnosis of active tuberculosis (ATB) currently relies on detection Mycobacterium (Mtb). Identifying patients with extrapulmonary TB (EPTB) remains challenging because microbiological confirmation is often not possible. Highly accurate blood-based tests could improve diagnosis both EPTB and pulmonary (PTB) timely initiation anti-TB therapy. Methods A case-control study was performed using discriminant analyses to validate an approach Mtb-specific CD4+T-cell activation...
The COVID-19 pandemic disrupted tuberculosis control programmes globally; whether or not this disproportionately affected people who were incarcerated is unknown. We aimed to evaluate changes in incarceration and notifications prisons Europe the Americas during pandemic. Data from WHO Pan American Health Organization (PAHO) used conduct a joint hierarchical Bayesian negative binomial time-series. This approach accounted for world region, country-specific temporal trends, autocorrelated...
Tuberculosis (TB) remains a major plague of humanity. People with TB (PWTB) are commonly anemic. Here, we assessed whether the severity anemia in PWTB prior to anti-TB treatment (ATT) was risk factor for an unfavorable outcome.
It is unclear whether diabetes or prediabetes affects unfavorable treatment outcomes and death in people with tuberculosis (PWTB).
Tuberculosis (TB) still causes significant morbidity and mortality worldwide, especially in persons living with human immunodeficiency virus (HIV). This disease is hallmarked by persistent oxidative stress systemic inflammation. N-acetylcysteine (NAC), a glutathione (GSH) precursor, has been shown experimental models to limit Mycobacterium tuberculosis infection both suppression of the host response through direct antimicrobial activity. In recent phase II randomized clinical trial...
Introduction Anemia frequently affects people living with HIV (PLHIV). Nevertheless, the impact of anemia on treatment outcomes patients HIV-associated tuberculosis (TB) and underlying molecular profiles are not fully characterized. The aim this study was to investigate interplay between anemia, systemic inflammatory profile, dissemination TB death in HIV-TB an ad hoc analysis results from a prospective cohort study. Methods 496 hospitalized PLHIV ≥18 years old, CD4 count <350...
Approximately 1.4 million people die annually worldwide from tuberculosis. Large epidemiologic studies can identify determinants of unfavorable clinical outcomes according to age, which guide public health policy implementation and management improve outcomes. We obtained data the national tuberculosis case registry; were reported Brazilian National Program (SINAN) between 2010 2019. Clinical variables compared age groups (child: <10 years, young: 10-24years, adult: 25-64years, elderly:...
Tuberculosis-diabetes mellitus (TB-DM) is linked to a distinct inflammatory profile, which can be assessed using multi-omics analyses. Here, machine learning algorithm was applied multi-platform data, including cytokines and gene expression in peripheral blood eicosanoids urine, Brazilian multi-center TB cohort. There were four clinical groups: TB-DM(n = 24), only(n 28), DM(HbA1c ≥ 6.5%) 11), control group of close contacts who did not have or DM(n 13). After cross-validation, baseline...
SummaryBackgroundSince 2014, Brazil has gradually implemented the Xpert MTB/RIF (Xpert) test to enhance early tuberculosis (TB) and drug-resistant (DR-TB) detection control, yet its nationwide impact remains underexplored. Our study conducts an intervention time-series analysis (ITSA) evaluate how Xpert's implementation improved TB DR-TB nationwide.Methods1,061,776 cases from Brazil's National Registry (2011–2022) were reviewed ITSA (2011–2019) was used gauge of adoption on notification....
Dysglycemia (i.e., prediabetes or diabetes) in patients with tuberculosis (PWTB) is associated increased odds of mortality and treatment failure. Whether such association holds true when dysglycemia transient persistent unknown. In this study, we tested the between (PD) during anti-tuberculosis (TB) unfavorable outcomes PWTB from Lima, Peru.PWTB enrolled February November 2017 were followed for 24-months. was measured through fasting glucose HbA1c at baseline 2nd- 6th-month TB treatment. PD...
People with HIV (PWH) are at increased risk of developing active tuberculosis (TB), and anemia is a common complication in both conditions. Anemia TB patients has been linked to immune activation, levels inflammatory biomarkers blood, for disease progression death. In this study we show that was associated more pronounced profile HIV-TB coinfected persons cohort 159 individuals advanced (CD4 count &lt; 100 cells/µL) recruited as part randomized clinical trial (NCT00988780). A panel...
SPECIALTY GRAND CHALLENGE article Front. Trop. Dis, 29 March 2023Sec. Major Tropical Diseases Volume 4 - 2023 | https://doi.org/10.3389/fitd.2023.1180606
Most persons living with HIV (PLWH) experience a significant restoration of their immunity associated successful inhibition viral replication after antiretroviral therapy (ART) initiation. Nevertheless, the robust quantitative and qualitative CD4 + T-lymphocytes, fraction patients co-infected tuberculosis develop immune reconstitution inflammatory syndrome (TB-IRIS), dysregulated response that can be tissue damage. Several studies underscored role adaptive cells in IRIS pathogenesis, but to...
Abstract Background Identifying patients at increased risk of loss to follow-up (LTFU) is key developing strategies optimize the clinical management tuberculosis (TB). The use national registry data in prediction models may be a useful tool inform healthcare workers about LTFU. Here we developed score predict LTFU during anti-TB treatment (ATT) nationwide cohort cases using reported Brazilian Notifiable Disease Information System (SINAN). Methods We performed retrospective study all TB SINAN...
Abstract Not every neonate with congenital Zika virus (ZIKV) infection (CZI) is born microcephaly. We compared inflammation mediators in CSF (cerebrospinal fluid obtained from lumbar puncture) between ZIKV-exposed neonates with/without microcephaly (cases) and controls. In Brazil, the same laboratory, we identified 14 during ZIKV epidemic (2015–2016), 7(50%) without microcephaly, any other infection, (2017–2018) eligible to be controls match cases. 29 were measured using Luminex immunoassay...
Background: The patients with coronavirus disease 2019 (COVID-19) associated severe acute respiratory distress syndrome (ARDS) may require prolonged mechanical ventilation which often results in lung fibrosis, thus worsening the prognosis and increasing fatality rates. A mesenchymal stromal cell (MSC) therapy decrease inflammation accelerate recovery COVID-19. In this context, some studies have reported effects of MSC for not requiring invasive or during first hours tracheal intubation....
Background Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is a clinical aggravation of TB symptoms observed among fraction HIV coinfected patients shortly after the start antiretroviral therapy (ART). Of note, TB-IRIS characterized by exacerbated inflammation and tissue damage that occurs in response to elevated production CD4 + T cell-derived IFN-γ. Nevertheless, possible participation CD8 cells development remains unclear. Methods We performed comprehensive...