A5052240391- Analytical Chemistry and Chromatography
- Microfluidic and Capillary Electrophoresis Applications
- Phytochemistry Medicinal Plant Applications
- Analytical Chemistry and Sensors
- Electrochemical sensors and biosensors
- Phytochemical compounds biological activities
- Natural Compound Pharmacology Studies
- Analytical Methods in Pharmaceuticals
- Traditional and Medicinal Uses of Annonaceae
- Metabolomics and Mass Spectrometry Studies
- Natural product bioactivities and synthesis
- Insect Pest Control Strategies
- Synthesis of Organic Compounds
- Carbohydrate Chemistry and Synthesis
- Bipolar Disorder and Treatment
- Chemistry and Chemical Engineering
- HIV/AIDS drug development and treatment
- Toxoplasma gondii Research Studies
- Plant-Derived Bioactive Compounds
- Hormonal and reproductive studies
- Skin Protection and Aging
- Tea Polyphenols and Effects
- Essential Oils and Antimicrobial Activity
- Plant Micronutrient Interactions and Effects
- Piperaceae Chemical and Biological Studies
Universidade Federal de Jataí
2016-2022
Universidade Federal de Goiás
2016-2020
Universidade Federal de Alfenas
2014-2015
Universidade de São Paulo
2004-2011
Universidade Federal de Viçosa
2008
Universidade Federal Fluminense
2007
Universidade Federal de São Carlos
2004
Praziquantel is the drug of choice for treatment schistosomiasis. However, several strains <i>Schistosoma mansoni</i> are resistant to praziquantel, making it necessary discover new drugs that might be used its treatment. With this in mind, properties a schistosomicidal ethanolic extract <i>Garcinia brasiliensis</i> Mart. epicarp, fractions obtained by partitioning extract, including hexane fractions, ethyl acetate fraction, and aqueous isolated compounds 7-epiclusianone, major component...
Abstract In this work, the separation of 11 natural and synthetic steroids was studied using MEKC electrolytes modified by property‐selected organic solvents: ethanol, ACN, THF. The interplay between electrophoretic behavior structural features disclosed effects modifiers to modulate retention alter selectivity were discussed in terms system linear solvation energy relationships (LSER). LSER indicated total solvent percentage electrolyte as a major parameter control minor contribution,...
Considerando a grande relevância das questões relacionadas ao impacto ambiental, o desenvolvimento de solventes ecológicos ligados à Química Verde, que foca na aplicação processos químicos em prol do sustentável, tem se tornado cada vez mais importante. Os Solventes Eutéticos Naturais Profundos, verdes com propriedades químicas versáteis, vêm ganhando espaço extração compostos bioativos. O objetivo deste estudo foi analisar tendências produtividade científica publicações utilizando NADES...
A simple and fast capillary zone electrophoresis (CZE) method has been developed validated for quantification of a non-nucleoside reverse transcriptase inhibitor (NNRTI) nevirapine, in pharmaceuticals. The analysis was optimized using 10 mmol L-1 sodium phosphate buffer pH 2.5, +25 kV applied voltage, hydrodynamic injection 0.5 psi 5 s direct UV detection at 200 µm. Diazepam (50.0 µg mL-1) used as internal standard. Under these conditions, nevirapine analyzed approximately less than 2.5 min....
In Brazilian folk medicine, Murraya paniculata has been used for treating intestine disorders, rheumatism and cough. This paper aims to investigate the in vitro antileishmanial antioxidant activities of essential oils (EO) from M. leaves fruits (ripe unripe ones). Natural antioxidants may be very beneficial improve quality life, since they are capable protecting body against damage caused by free radicals and, consequently, either preventing or postponing many diseases starting their cycles....
The prior study of the extraction path is fundamental to optimize required time and define most suitable solvent extract determine an analyte interest in a complex sample. This aimed evaluate four modes; sequence Soxhlet equipment (SES), by maceration (SEM), direct with ethanol (EEM), (EES), Garcinia brasiliensis bioactive compounds using validated high-performance liquid chromatography diode-array detection (HPLC-DAD) method. Fukugetin, fukugetina-7’’-O-β-D-glucoside, norathyriol,...
Abstract Introduction – A large number of natural and synthetic compounds having butenolides as a core unit have been described many them display wide range biological activities. Butenolides from P. malacophyllum presented potential antifungal activities but no specific, fast, precise method has developed for their determination. Objective To develop methodology based on micellar electrokinetic chromatography to determine in Piper species. Methodology The extracts were analysed an uncoated...
Estudos de plantas provinentes do Cerrado brasileiro tem ganhado destaque devido à busca por novos compostos com atividades terapêuticas. Entre as espécies, destaca-se a Annona crassiflora Mart., para qual anti-inflamatórias, antioxidantes e antitumorais já foram relatadas. Os principais bioativos encontrados nesta planta são acetogeninas, flavonoides alcaloides. O uso técnicas computacionais, como o docking molecular, sido utilizado descoberta partir potencial medicinal. Neste trabalho, foi...
The combination of computational methods and experimental data from Nuclear Magnetic Resonance (NMR) is a considerably valuable tool in the elucidation new natural product structures and, also, structural revision previously reported compounds. Until recently, only classical statistical parameters were used, for example, linear correlation coefficient (R2 ), mean absolute error (MAE), or root square deviation (RMSD), as way to statistically "validate" structure pointed out by NMR spectra....
O câncer e uma doenca caracterizada por crescimento celular desordenado em decorrencia de mutacoes geneticas fatores ambientais, podendo acometer os mais variados tecidos orgaos, alem se disseminar para distantes do foco inicial atraves da corrente sanguinea vasos linfaticos. mama, classificado acordo com as celulas acometidas intraductal ou intralobular, representa 20% todos tipos existentes no mundo. Seu tratamento abrange varias abordagens terapeuticas, sendo que cada qual possui eficacia...
A rapid and simple microemulsion electrokinetic chromatography (MEEKC) method has been developed validated for the determination of ethinylestradiol levo-norgestrel in a commercial tablet formulation. The analysis was performed with an electrolyte composed 0.5% (w/w) ethyl acetate, 1.2% butan-1-ol, 0.6% sodium dodecyl sulfate, 15% (v/v) ethanol 82.7% 12 mmol L−1 tetraborate aqueous buffer at pH 9.23 direct UV detection 200 247 nm. For quantitative purposes, estrone used as internal standard....
Caryocar brasiliense, popularmente conhecido como pequi, é uma espécie que apresenta alto teor de compostos fenólicos com propriedades biológicas. Neste trabalho, o processo extração assistida por ultrassom, bioativos das folhas do foi otimizado planejamento fatorial Box-Behnken. Quatro variáveis independentes foram avaliadas: concentração da amostra (relação:líquido-sólido (L-S), proporção etanol na solução (EtOH/H2O % v/v), tempo EAU (extração ultrassom) e temperatura. A metodologia...
Epidemiological and experimental studies have found that the consumption of regular coffee has various health benefits. In present study, we investigated effect decaffeinated extracts on inflammation process aqueous green roasted anti-inflammatory activity. The antioxidant effects extract (AD) ethanol (ED) were evaluated in animal models using a DPPH radical scavenging test. formalin test, reduced licking activity both late phases. inhibitory values oedema 3 h post-carrageenan indicated an...