Description of the subject. Essential oils are volatile fractions produced through special metabolism plants. One significant biological application essential in recent years has been their use as bioherbicides, due to important biocide effect. Objectives. This study aims identify chemical constituents Aloysia gratissima (Gillies & Hook.) Tronc. oil and assess its potential. Method. describes, for first time, constitution from seeds A. gratissima. To verify possible effect, lettuce were...

Five 2-aroylbenzofurans were synthesized by condensation between α-bromoacetone and an ortho-hydroxybenzaldehyde or ortho-hydroxy-acetophenone evaluated for their in vitro antischistomal effects against adult Schistosoma mansoni worms. Below 200 µg/mL, none of the tested killed S. On other hand, at µg/mL all compounds reduced motor activity worms after treatment 72 h. At compound 1 was only one to decrease 67% incubation 24 The methyl group C6 nature substituent ring A play important roles...

We have investigated the chemical composition and antibacterial activity of essential oil Dysphania ambrosioides (L.) Mosyakin & Clemants (Chenopodiaceae) ( DA ‐ EO ) against a representative panel cariogenic bacteria. also assessed in vitro schistosomicidal effects on Schistosoma mansoni its cytotoxicity to GM 07492‐A cells . Gas chromatography GC gas chromatography‐mass spectrometry / MS revealed that monoterpenes cis ‐piperitone oxide (35.2%), p ‐cymene (14.5%), isoascaridole (14.1%),...

This study reports on the chemical composition and antimicrobial activity of essential oil from Artemisia absinthium L. leaves AA EO collected in Brazil against a representative panel cariogenic bacteria. The minimum inhibitory concentrations MICs were determined by broth dilution method 96-well microplates. was inactive most investigated oral pathogens, but it displayed moderate Streptococcus mutans MIC = 250 μg/mL very promising mitis 62.5 μg/mL. Gas chromatography GC FID gas mass...

Abstract We have evaluated eight p ‐coumaric acid prenylated derivatives in vitro for their antileishmanial activity against Leishmania amazonensis promastigotes and antischistosomal Schistosoma mansoni adult worms. Compound 7 (( E )‐3,4‐diprenyl‐4‐isoprenyloxycinnamic alcohol) was the most active L. (IC 50 =45.92 μM) S. =64.25 μM). Data indicated that number of prenyl groups, presence hydroxyl at C9, a single bond between C7 C8 are important structural features derivatives.

Aim: Geraniol and linalool are major constituents of the essential oils medicinal plants. Materials & methods: Antifungal activity geraniol were evaluated against five Candida species. The genotoxicity these compounds was by cytokinesis-block micronucleus test, embryotoxic assays use zebrafish model. Results: inhibited growth, but more effective. at concentration 800 μg/ml 125 significantly increased chromosome damage. toxic to embryo than linalool: LC50 values 31.3 193.3 μg/ml,...

This study aimed to investigate the chemical composition as well antibacterial, antiparasitic, and cytotoxic potentialities of Brazilian Chrysopogon zizanioides root essential oil (CZ-EO) In addition, CZ-EO cytotoxicity LLCMK2 adherent epithelial cells was assessed. The major compounds identified in were khusimol (30.0 ± 0.3%), β-eudesmol (10.8 α-muurolene (6.0 0.1%), patchouli alcohol (5.6 0.2%). displayed optimal antibacterial activity against Prevotella nigrescens, Fusobacterium...

We report the in vitro schistosomicidal effects of essential oil obtained from Citrus limonia leaves (CL-EO) and C. reticulata fruit peels (CR-EO), cultivated Brazil, against Schistosoma mansoni worms. Limonene (29.9%), β-pinene (12.0%), sabinene (9.0%), citronellal citronellol (5.8%) are major constituents CL-EO; limonene (26.5%), γ-terpinene (17.2%), linalool (11.1%), octanal (8.0%), myrcene (6.2%), capraldehyde (3.9%) predominate CR-EO. CL-EO displayed moderate lethal concentration 50%...

Artepillin C, drupanin, and plicatin B are prenylated phenylpropanoids that naturally occur in Brazilian green propolis. In this study, these compounds eleven of their derivatives were synthesized evaluated for vitro antimicrobial activity against a representative panel oral bacteria terms minimum inhibitory concentration (MIC) bactericidal (MBC) values. Plicatin (

We investigated the gas-phase fragmentation reactions of a series 2-aroylbenzofuran derivatives by electrospray ionization tandem mass spectrometry (ESI-MS/MS). The most intense fragment ions were acylium m/z 105 and [M+H-C6 H6 ]+ , which originated directly from precursor ion as result 2 competitive hydrogen rearrangements. Eliminations CO CO2 also common processes to all analyzed compounds. In addition, eliminations radicals •Br •Cl diagnostic for halogen atoms at aromatic ring A, whereas...

Abstract The main pathogen underlying citrus variegated chlorosis (CVC), a fruit disease, is Xylella fastidiosa , Gram‐negative s‐shaped bacterium that blocks water and nutrient circulation. Discovering new pesticides to combat CVC have become challenge. Research into essential oils (EOs) crucial because these substances can be potentially useful in pest control. This study aims determine minimum inhibitory concentrations (MIC), investigate biofilm inhibition capacities through MBIC 50...

We evaluated the antimicrobial activity of 25 monoketone curcuminoids (MKCs) against a representative panel cariogenic bacteria in terms their minimum inhibitory concentration (MIC) values. Curcumin A (10) displayed promising Streptococcus mutans (MIC = 50 μg/ml) and mitis as well moderate S. sanguinis 100 μg/ml), Lactobacillus casei salivarius 200 μg/ml). Results indicated higher compound 10 than that its bis-β-diketone analog. Additionally, compounds 3a...

Besides their value as therapeutic resources, medicinal plants may also be used sources of active ingredients against phytopathogens. Fungi can grow and cause spoilage in food, thus, resusting decrease its quality quantity. This research aimed at evaluating the effect essential oil from Murraya paniculata (ML-EO) leaves on mycelial growth Sclerotinia sclerotiorum, a fungus that poses high risk to several cultures, mainly soybean. Essential M. (Rutaceae) was obtained by hydrodistillation...

Curcumin (or diferuloylmethane), a component of Curcuma longa L. rhizomes, displays various biological and pharmacological activities. However, it is poorly bioavailable unstable in physiological pH. In this review, we cover papers published between 2019 2023 on the synthesis activities more stable effective curcumin analogs known as monoketone curcuminoids (MKCs) or “monocarbonyl curcuminoids.” Recent advances Claisen–Schmidt condensation, standard procedure to synthesize MKCs, including...

Nectandra megapotamica is a tree species that naturally occurs in the Atlantic Forest, Brazil. This paper aims to investigate chemical composition and vitro antibacterial, antileishmanial antiproliferative activities of essential oil from N. leaves (NM-EO). It displayed high antibacterial activity against Streptococcus mutans, S. sobrinus, Prevotella nigrescens Bacteroides fragilis. NM-EO also exhibited promastigote forms Leishmania amazonensis. Its was evaluated following cells: GM07429A...

Essential oils (EOs) from Citrus are not only economic, eco-friendly and natural alternatives to chemical preservatives but also have other biological applications. This study aimed investigate the composition of species (EOs C. limonia, latifolia, sinensis deliciosa fruit peel) evaluate their in vitro antibacterial activity against Listeria monocytogenes, Yersinia enterocolitica, Staphylococcus aureus, Clostridium botulinum Bacillus cereus. The chemotaxis model, which was used for...

This study aims to investigate chemical composition of essential oils from Murraya paniculata (L.) Jack (Rutaceae) ripe and unripe fruits determine their in vitro antibacterial activity. Essential were extracted by hydrodistillation collected the Cerrado, Rio Verde, southwestern Goiás, Brazil. They analyzed gas chromatography with flame ionization detector (GC-FID) chromatography-mass spectrometry (GC-MS). Sesquiterpenes, which represent most abundant class compounds oils, predominated both...

Chagas disease is a tropical caused by the protozoan parasite Trypanosoma cruzi and currently affects millions of people worldwide. Curcumin (CUR), major constituent turmeric spice (dry powder Curcuma longa L. plant rhizomes roots), exhibits antiparasitic activity against parasites in vitro. However, because its chemical instability, poor cellular uptake limited bioavailability it not suitable for clinical use. The objective this study was to synthesize evaluate vitro CUR monoketone analog...

In Brazilian folk medicine, Murraya paniculata has been used for treating intestine disorders, rheumatism and cough. This paper aims to investigate the in vitro antileishmanial antioxidant activities of essential oils (EO) from M. leaves fruits (ripe unripe ones). Natural antioxidants may be very beneficial improve quality life, since they are capable protecting body against damage caused by free radicals and, consequently, either preventing or postponing many diseases starting their cycles....

Spiranthera odoratissima A. St.-Hil. (Rutaceae) has been popularly used against abdominal pain and rheumatism. This study aimed at extracting hexane from S. (HE-SO) leaves to identify quantify its volatile compounds by GC-MS GC-FID evaluate antifungal, antileishmanial antibacterial activities in vitro. HE-SO exhibited activity promastigote forms of Leishmania (Leishmania) amazonensis (IC50 = 38.16 µg/mL) was moderately active Xylella fastidiosa (MIC 100 µg/mL). also showed remarkable...

Despite the current treatments against Chagas Disease (CD), this vector-borne parasitic disease remains a serious public health concern. In study, we have explored in vitro and/or vivo trypanocidal and cytotoxic activities of essential oils (EOs) obtained from Dysphania ambrosioides (L.) Mosyakin & Clemants (Amaranthaceae) (DA-EO), Lippia alba (Mill.) N.E. Brown (Verbenaceae) (LA-EO), Tetradenia riparia (Hochst.) Codd (Lamiaceae) (TR-EO) grown Brazil Southeast. DA-EO was most active...