A5072639236- Parasites and Host Interactions
- Research on Leishmaniasis Studies
- Insect Pest Control Strategies
- Parasite Biology and Host Interactions
- Helminth infection and control
- Essential Oils and Antimicrobial Activity
- Phytochemical compounds biological activities
- Trypanosoma species research and implications
- Bee Products Chemical Analysis
- Phytochemistry Medicinal Plant Applications
- Trace Elements in Health
- Insect and Pesticide Research
- Toxin Mechanisms and Immunotoxins
- Plant-derived Lignans Synthesis and Bioactivity
- Traditional and Medicinal Uses of Annonaceae
- Plant Toxicity and Pharmacological Properties
- Natural product bioactivities and synthesis
- Curcumin's Biomedical Applications
- Sesquiterpenes and Asteraceae Studies
- Phytochemistry and Biological Activities
- Phytochemistry and Bioactivity Studies
- Agricultural and Food Sciences
- Insect Resistance and Genetics
- Allelopathy and phytotoxic interactions
- Piperaceae Chemical and Biological Studies
Universidade de Franca
2016-2025
Universidade de São Paulo
2008-2025
Zero to Three
2022
Instituto Federal Goiano
2021
Center for Discovery
2021
University of California, San Diego
2021
Center for Effective Philanthropy
2021
University of Montana
2021
Universidade de Ribeirão Preto
2009-2016
Pontifícia Universidade Católica de Goiás
2015
Abstract Baccharis dracunculifolia DC. (Asteraceae), popularly known as ‘ alecrim do campo ’, is a native plant from Brazil used in folk medicine febrifuge, anti‐inflammatory, antiseptic, and to treat skin sores. Also, B. the most important source of Brazilian green propolis, which recognized for its antiseptic antiprotozoal activities. This study aimed at investigating vitro antiprotozoal, schistosomicidal, antimicrobial activities essential oil leaves dracunculifolia. The was obtained by...
The in vitro schistosomicidal effects of the essential oil Ageratum conyzoides L. (Ac-EO) against adult worms Schistosoma mansoni is reported this paper. Concerning activity, Ac-EO was considered to be active, but less effective than positive control (praziquantel, PZQ) terms separation coupled pairs, mortality, decrease motor and tegumental alterations. However, caused an interesting dose-dependent reduction number eggs S. mansoni. Precocene I (74.30%) (E)-caryophyllene (14.23%) were...
Inducing apoptosis is an interesting therapeutic approach to develop drugs that act against helminthic parasites. Researchers have investigated how curcumin (CUR), a biologically active compound extracted from rhizomes of Curcuma longa, affects Schistosoma mansoni and several cancer cell lines. This study evaluates CUR influences the induction oxidative stress in couples adult S. worms. decreased viability worms killed them. The tegument parasite suffered morphological changes, mitochondria...
Abstract The chemical composition and the in vitro schistosomicidal effects of essential oil Plectranthus neochilus (PN‐EO) grown Southeast Brazil was studied. β ‐Caryophyllene ( 1 ; 28.23%), α ‐thujene 2 12.22%), ‐pinene 3 12.63%), 4 6.19%), germacrene D 5 5.36%), caryophyllene oxide 6 5.37%) were major constituents. This differed from that previously reported for specimens harvested Africa. Concerning activity against adult Schistosoma mansoni worms, PN‐EO considered to be active, but less...
Trypanosoma brucei is a protozoan parasite that causes Human African Trypanosomiasis (HAT), neglected tropical disease (NTD) endemic in 36 countries sub-Saharan Africa. Only handful drugs are available for treatment, and these have limitations, including toxicity drug resistance. Using the natural product, curcumin, as starting point, several curcuminoids related analogs were evaluated against bloodstream forms of T. b. brucei. A particular subset dibenzylideneacetone (DBA) compounds...
This study reports on the chemical composition and antileishmanial anticandidal activities of essential oils (EOs) distilled from Schinus molle dried leaves (SM-EO), Cinnamomum cassia branch bark (CC-EO) their blends against promastigote forms Leishmania (Leishmania) ama-zonensis nine Candida strains. Major constituents SM-EO were spathulenol (26.93%), β-caryophyllene (19.90%), caryophyllene oxide (12.69%), whereas cinnamaldehyde (60.11%), cinnamyl acetate (20.90%) (E)-cis-2-methoxycinnamic...
This study examines the effect of surfactant-enhanced enzymatic hydrolysis on eucalyptus Kraft pulps produced under high (CPHA) and mild (CPMA) alkali conditions to optimize saccharification sugar yield. Compositional analysis revealed an increase in glucan content, from 40% untreated 70.1% CPHA. Both were hydrolyzed using Cellic® CTec3 HS enzyme (Novozymes). A 22 factorial design maximum conversion (~100%) with loading 10 FPU/g carbohydrate 10% (w/v) solids. Tween 20 significantly boosted...
More than 2.5 billion people live in endemic areas for neglected tropical diseases caused by the protozoan Trypanosoma cruzi. Which establishes chronic infections and increases public health spending. Thus, this paper describes chemical study of Usnea steineri acetone extract evaluations trypanocidal activity vitro vivo. Four constituents from have been isolated: usnic acid, diffractaic galbinic norstictic acid. The U. revealed an IC50 49.4 ± 1.5 µg/mL regarding trypomastigote T. cruzi...
A Base Nacional Comum Curricular é o documento norteador da Educação Básica Brasileira. Este alvo de críticas e defesas por diversos lados, este artigo traz reflexões a respeito. Seu objetivo analisar aspectos positivos negativos BNCC segundo visão alguns autores. Para isso, desenvolveu-se uma pesquisa bibliográfica do tipo revisão narrativa meio estudo artigos científicos. análise dos dados estudados seguiu livre interpretação, ou seja, foi realizada maneira reflexiva, aberta forma...
Abstract Chagas disease, caused by the protozoan Trypanosoma cruzi , affects 6–7 million people worldwide, mainly in South and Central America. A key enzyme disease's progression is trans‐sialidase ( TcTS ), which facilitates parasite invasion transferring sialic acid residues from host glycoconjugates to parasite's surface mucins. Given potential of acid‐based inhibitors block activity, we designed synthesized novel sialylmimetics using quinic shikimic acids. These precursors were chosen...
Five 2-aroylbenzofurans were synthesized by condensation between α-bromoacetone and an ortho-hydroxybenzaldehyde or ortho-hydroxy-acetophenone evaluated for their in vitro antischistomal effects against adult Schistosoma mansoni worms. Below 200 µg/mL, none of the tested killed S. On other hand, at µg/mL all compounds reduced motor activity worms after treatment 72 h. At compound 1 was only one to decrease 67% incubation 24 The methyl group C6 nature substituent ring A play important roles...
The in vitro activity of the crude hydroalcoholic extract aerial parts Miconia langsdorffii Cogn. was evaluated against promastigote forms L. amazonensis, causative agent cutaneous leishmaniasis humans. bioassay-guided fractionation this led to identification triterpenes ursolic acid and oleanolic as major compounds fraction that displayed highest activity. Several semi-synthetic derivatives were prepared, find out whether more active could be obtained. Among these acid-derived substances,...
This paper reports on the chemical composition, in vitro antischistosomal effects, and cytotoxicity of essential oil from leaves Lavandula angustifolia Mill., Lamiaceae, grown Southeastern Brazil. Borneol (22.4%), epi-α-muurolol (13.4%), α-bisabolol (13.1%), precocene I (13.0%), eucalyptol (7.9%) were major constituents. Incubation with at 200 μg/ml killed all adult S. mansoni worms after 24 h (LC50 117.7 103.9 120 incubation, respectively). At a concentration 50 μg/ ml, significantly...