The extract and essential oil of clove (Syzygium aromaticum) are widely used because their medicinal properties. Eugenol is the most important component clove, showing several biological Herein we have analysed immunomodulatory/anti-inflammatory effect eugenol on cytokine production (interleukin (IL)-1β, IL-6 IL-10) in vitro.Macrophages were incubated with or (5, 10, 25, 50 100µg/well) for 24h. Concentrations that inhibited cytokines before after incubation lipopolysaccharide (LPS), to...

Abstract In the present work, anticariogenic activities of nine labdane type‐diterpenes and four sesquiterpenes were investigated. Among these metabolites, (‐)‐copalic acid (CA) was most active compound displaying MIC values very promising (ranging from 2.0 to 6.0 µg/mL) against main microorganisms responsible for dental caries: Streptococcus salivarius, S. sobrinus, mutans, mitis, sanguinis Lactobacillus casei . Time kill assays performed with CA primary causative agent ( mutans ) revealed...

Abstract Baccharis dracunculifolia DC. (Asteraceae), popularly known as ‘ alecrim do campo ’, is a native plant from Brazil used in folk medicine febrifuge, anti‐inflammatory, antiseptic, and to treat skin sores. Also, B. the most important source of Brazilian green propolis, which recognized for its antiseptic antiprotozoal activities. This study aimed at investigating vitro antiprotozoal, schistosomicidal, antimicrobial activities essential oil leaves dracunculifolia. The was obtained by...

The aim of this work was to evaluate the antiviral activities Baccharis dracunculifolia (extract and essential oil), propolis some isolated compounds (caffeic cinnamic acids) against poliovirus type 1 (PV1) replication in HEp-2 cells.Three different protocols (pre-, simultaneous post-treatments) were used verify effect addition time variables on PV1 by crystal violet method relative viral RNA quantification real-time PCR for analysing which step virus could interfere.Data revealed that B....

Baccharis dracunculifolia D.C. (Asteraceae) is the most important plant source of Brazilian green propolis. Since propolis known for its antimicrobial activity, aim this work was to evaluate activities B. and some isolated compounds. The results showed that leaves extract (BdE) presents antifungal antibacterial activities, especially against Candida krusei Cryptococcus neoformans, which BdE IC 50 values 65 μg mL −1 40 , respectively. In comparison BdE, it observed (GPE) better displaying an...

A sensitive and reliable RP-HPLC method was developed using a C18 CLC-ODS (M) - 4.6x250 mm(2)column gradient elution for the analysis of phenolic compounds in propolis raw material its products. procedure extraction aqueous ethanol (90%) with addition veratraldehyde as internal standard (IS) allowing to quantify ten compounds: caffeic acid, coumaric ferulic cinnamic aromadendrin-4'-methyl ether (AME), isosakuranetin, drupanin, artepellin C, baccharin,...

Baccharis dracunculifolia is the most important botanical source of Southeastern Brazilian propolis, known as green propolis for its colour. In a previous study, we described gastric protective effect hydroalcoholic extract propolis. We therefore wanted to investigate possibility using B. antiulcer treatment. This study was undertaken evaluate anti-ulcerogenic property aerial parts. The HPLC analysis chemical composition used in this revealed presence mainly cinnamic acid derivates and...

Gastric ulcer is a prevalent gastrointestinal disease, and the drugs currently used in treatment produce several adverse effects. In this context, search for new therapeutic antiulcer agents essential, medicinal plants have great potential. Here, we investigated gastroprotective properties of Copaifera langsdorffii Desf., Fabaceae, hydroalcoholic extract obtained from leaves its isolated compounds. The phytochemistry studies compounds isolations were performed using chromatographic...

Abstract Baccharis dracunculifolia DC (Asteraceae), a native plant from Brazil, commonly known as ‘Alecrimdo‐campo’ is widely used in folk medicine to treat inflammation, hepatic disorders and stomach ulcers, it the most important botanical source of Southeastern Brazilian propolis, green propolis. Its essential oil composed non‐oxygenated oxygenated terpenes. In this work, effects obtained aerial parts B. on gastric ulcers were evaluated. The antiulcer assays undertaken using following...

Biological properties of clove have been reported, but little is known about its effect on the immune system. This work was aimed to investigate in vivo a water-soluble part hydroalcoholic extract pro-inflammatory cytokines (IL-1beta and IL-6) production by macrophages BALB/c mice. The action essential oil these also investigated vitro. chemical compositions were investigated. Treatment mice with water found inhibit produce both IL-1beta IL-6. inhibited Eugenol be major component oil,...

Baccharis dracunculifolia D.C. (Asteraceae), a shrub which grows wild in Brazil, is the main botanical source of Brazilian green propolis. Since propolis shows an immunomodulatory activity, goal this work was to evaluate action B. extracts and some its isolated compounds on reactive oxygen intermediate (H(2)O(2)) production by macrophages obtained from male BALB/c mice. The results showed that leaf (Bd-L) (25, 50, 100 microg mL(-1)), rinse (Bd-LR) (25 root (Bd-R) mL(-1)) enhanced H2O2...

The number of documented dengue cases has increased dramatically in recent years due to transmission through the Aedes aegypti mosquito bite. Vector control remains most effective measure protect against this and other arboviral diseases including Zika, chikungunya (urban) yellow fever, with an established vaccine only available for fever. Although quinone class shows potential as leading compounds larvicide development, limited information restricts development optimized structures and/or...

Própolis é um termo genérico utilizado para denominar o material resinoso e balsâmico coletado processado pelas abelhas a partir de várias fontes vegetais. A composição da própolis complexa ocorrem variações em função fatores como flora região, estações do ano características genéticas das abelhas. Sendo assim, objetivou-se neste trabalho realizarem-se análises controle qualidade físico-químico amostras própolis, provenientes seis diferentes locais situados nas microrregiões Franca (SP)...

This study investigated the potential use of topically and orally administered propolis extracts to prevent UV irradiation-induced oxidative stress in skin. The results illustrated that green extract (GPE) contained greater amounts polyphenols, coumaric acid, drupanin, baccharin artepillin C than did brown (BPE). GPE showed higher antioxidant activity BPE when IC(50) (concentration caused 50% inhibition) values were compared. Interesting, oral treatment hairless mice demonstrated a recovery...

Brazilian green propolis, which is used in food and beverages to improve health prevent diseases, demostrates antioxidant, antimutagenic, antimicrobial activities. Most biological activities are thought be related the high levels of drupanin, artepillin C, baccharin, compounds also present Baccharis dracunculifolia D.C. (Asteraceae). Since propolis chemical composition depends on region period collection, as well its plant origin, effect seasonal variation both content prenylated p-coumaric...

Abstract Introduction Baccharis dracunculifolia , which has great potential for the development of new phytotherapeutic medicines, is most important botanical source southeastern Brazilian propolis, known as green propolis on account its color. Objective To develop a reliable reverse‐phase HPLC chromatographic method analysis phenolic compounds in both B . raw material and hydroalcoholic extracts. Methodology The utilised C 18 CLC‐ODS (M) (4.6 × 250 mm) column with nonlinear gradient elution...

Cymbopogon citratus has been widely recognised for its ethnobotanical and medicinal usefulness. Its insecticidal, antimicrobial therapeutic properties have reported, but little is known about effect on the immune system. This work aimed to investigate in vivo of a water extract lemongrass pro-inflammatory cytokine (IL-1beta IL-6) production by macrophages BALB/c mice. The action essential oil was also analysed vitro. chemical composition investigated. Treatment mice with inhibited produce...

Baccharis dracunculifolia is the most important vegetal source of propolis in southeast Brazil, and researchers have been investigating its biological properties. Propolis a complex resinous hive product collected by bees from several plants, showing very chemical composition. It has employed since ancient times due to therapeutic properties, such as antimicrobial, anti-inflammatory, antioxidant, immunomodulatory antitumour activities, among others. The goal this work was compare cytotoxic...