A5034354424- Parasites and Host Interactions
- Phytochemistry Medicinal Plant Applications
- Trace Elements in Health
- Parasite Biology and Host Interactions
- Essential Oils and Antimicrobial Activity
- Ethnobotanical and Medicinal Plants Studies
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Research on Leishmaniasis Studies
- Fungal and yeast genetics research
- Microbial Natural Products and Biosynthesis
- Insect Resistance and Genetics
- Helminth infection and control
- Parasitic infections in humans and animals
- Phytochemistry and Bioactivity Studies
- Antifungal resistance and susceptibility
- Psidium guajava Extracts and Applications
- vaccines and immunoinformatics approaches
- Endoplasmic Reticulum Stress and Disease
- Cannabis and Cannabinoid Research
- Traditional and Medicinal Uses of Annonaceae
- Crop Yield and Soil Fertility
- Growth and nutrition in plants
- Obsessive-Compulsive Spectrum Disorders
- RNA modifications and cancer
Universidade de São Paulo
2008-2023
Universidade Federal de Uberlândia
2014-2023
Universidade de Ribeirão Preto
2013-2017
Inducing apoptosis is an interesting therapeutic approach to develop drugs that act against helminthic parasites. Researchers have investigated how curcumin (CUR), a biologically active compound extracted from rhizomes of Curcuma longa, affects Schistosoma mansoni and several cancer cell lines. This study evaluates CUR influences the induction oxidative stress in couples adult S. worms. decreased viability worms killed them. The tegument parasite suffered morphological changes, mitochondria...
Aspergillus fumigatus is an opportunistic pathogen and allergen of mammals. Calcium signalling essential for A. pathogenicity regulated by the CrzA transcription factor. We used ChIP-seq (Chromatin Immunoprecipitation DNA sequencing) to explore gene targets in fumigatus. In total, 165 potential binding peaks including 102 directly genes were identified, resulting prediction A[GT][CG]CA[AC][AG] CrzA-binding motif. The putatively exhibited a diverse array functions. phkB (Afu3g12530) histidine...
Schistosomiasis remains a severe problem of public health in developing countries. Several reports show that praziquantel, the drug choice for treating schistosomiasis, can select Schistosoma mansoni strains resistant to drug. Thus, new drugs against this parasitosis is highly desirable goal. Curcumin, phenolic compound deriving from plant Curcuma longa, has been shown have anticancer, anti-inflammatory and antiparasitic effects. Recently, our group demonstrated curcumin causes separation S....
Heterotrimeric G-protein-mediated signaling pathways play a pivotal role in transmembrane eukaryotes. Our main aim was to identify regulated by A. nidulans GprB and GprD G-protein coupled receptors (GPCRs). When these two null mutant strains were compared the wild-type strain, ΔgprB showed an increased protein kinase A (PKA) activity while growing glucose 1% during starvation. In contrast, ΔgprD has much lower PKA upon Transcriptomics (1)H NMR-based metabolomics performed on single mutants...
Proteasome is a proteolytic complex responsible for intracellular protein turnover in eukaryotes, archaea and some actinobacteria species. Previous work has demonstrated that Schistosoma mansoni parasites, the proteasome inhibitor MG-132 affects parasite development. However, molecular targets affected by S. are not entirely known. Here, we used expression microarrays to measure genome-wide changes gene of adult worms exposed vitro MG-132, followed silico functional analyses genes using...
Currently, the treatment of infectious diseases has not always been successful due to emergence microbial resistance worldwide.This study aimed evaluate antioxidant activity, content total phenolic compounds and flavonoids, antifungal potential antibacterial action six medicinal plants found in Cerrado, leaf extracts Boldo (Peumus boldus), Goiaba (Psidium guajava), Assa-Peixe (Vernonia polysphaera), Abacate (Persea americana), Eucalipto (Eucalyptus citriodora) raw sap Bálsamo (Jatropha...
Aspergillus fumigatus is an opportunistic fungal pathogen and the most important species causing pulmonary infections. The signaling by calcium very for A. pathogenicity it regulated transcription factor CrzA. We have previously used ChIP-seq (Chromatin Immunoprecipitation DNA sequencing) aiming to identify gene targets identified among several genes stress, putative flavin transporter, flcA. This transporter belongs a small protein family composed of FlcA, B, C. ΔflcA null mutant showed...
There is currently growing interest in the investigation of bioactive compounds from natural sources. In this context,this study investigated phenolic content, antioxidant capacity, and antimicrobial activity hydroalcoholic extract (EHA) thestem barks leaves Stryphnodendron adstringens. Plant parts were extracted with ethanol:water (1:1) fi ltered a vacuumto obtain crude extract. Phenolic content was determined by Folin–Ciocalteu method. Antioxidant measuredusing DPPH test. The extracts...
BACKGROUND Key genes control the infectivity of Schistosoma haematobium causing schistosomiasis. A method for understanding regulation these might help in developing new disease strategies to schistosomiasis, such as silencing mediated by microRNAs (miRNAs). The miRNAs have been studied schistosome species and they play important roles post-transcriptional genes, parasite-host interactions. However, genome-wide identification characterisation novel their pathway gene expression not explored...
Schistosomiasis, a chronic disease that affects million people worldwide, is caused by trematode flukes of the genus Schistosoma. The lack an anti-schistosomiasis vaccine and massive monotherapy with praziquantel reinforces need for search development new therapeutic drugs. Recently, we demonstrated essential oil Piper cubeba L., Piperaceae, their derivative dibenzylbutyrolactolic (−)-6,6′-dinitrohinokinin, presents in vitro vivo activities against Schistosoma mansoni. Here, identified...
Currently, biofilm-forming bacteria are difficult to treat by conventional antibiotic therapy and are, thus, becoming a clinical epidemiological problem worldwide. Medicinal plants have been identified as novel alternative treatments due their therapeutic antimicrobial effects. In this context, the present study aimed determine total phenolic content, antioxidant capacity, anti-biofilm potential of nine extracts Hymenaea courbaril (Fabaceae), popularly known Jatobá. Furthermore, that...
BACKGROUND Biomphalaria glabrata is the major species used for study of schistosomiasis-related parasite-host relationships, and understanding its gene regulation may aid in this endeavor. The ubiquitin-proteasome system (UPS) performs post-translational order to maintain cellular protein homeostasis related several mechanisms, including immune responses. OBJECTIVE aims work were identify characterise putative genes proteins involved UPS using bioinformatic tools also their expression on...
Introdução: Caryocar brasiliense é uma planta medicinal utilizada no tratamento de doenças respiratórias, úlceras gástricas e dores musculares. Objetivo: comparar a extração compostos naturais por meio dois métodos extrativos, agitação magnética banho ultrassônico. Além disso, avaliar atividade antioxidante, o teor fenólicos, flavonoides antocianinas das folhas casca Pequi (C. brasiliense), com vistas agregar valor suas propriedades funcionais. Metodologia: conteúdo fenólico foi determinado...