A5089235093- Macrophage Migration Inhibitory Factor
- Pregnancy and preeclampsia studies
- Effects and risks of endocrine disrupting chemicals
- Reproductive System and Pregnancy
- Cardiovascular Issues in Pregnancy
- Toxoplasma gondii Research Studies
- Cytomegalovirus and herpesvirus research
- Birth, Development, and Health
- Endometriosis Research and Treatment
- Autophagy in Disease and Therapy
- Neonatal Respiratory Health Research
- Toxic Organic Pollutants Impact
- Parasitic Infections and Diagnostics
- Pregnancy-related medical research
- Gestational Diabetes Research and Management
- Pregnancy and Medication Impact
- Drug Transport and Resistance Mechanisms
- Reproductive Physiology in Livestock
- Cancer, Hypoxia, and Metabolism
- Cancer Risks and Factors
- Cholesterol and Lipid Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Reproductive Biology and Fertility
- MicroRNA in disease regulation
- Galectins and Cancer Biology
University of Siena
2015-2024
Polish Academy of Sciences
2015
Institute of Animal Reproduction and Food Research
2015
Mount Sinai Hospital
2005-2010
Lunenfeld-Tanenbaum Research Institute
2010
University of Toronto
2006
Abstract Background: Oxygen plays a central role in human placental pathologies including preeclampsia, leading cause of fetal and maternal death morbidity. Insufficient uteroplacental oxygenation preeclampsia is believed to be responsible for the molecular events clinical manifestations this disease. Design: Using high-throughput functional genomics, we determined global gene expression profiles placentae from high altitude pregnancies, natural vivo model chronic hypoxia, as well that...
The human placenta is a unique organ in terms of oxygenation as it undergoes transition from low to more oxygenated environment. This physiological switch oxygen tension prerequisite for proper placental development and involves the hypoxia inducible factor (HIF). HIF stable initiates gene transcription under hypoxia, whereas normoxia, interaction with von Hippel-Lindau tumor suppressor protein (VHL) leads rapid degradation HIF1A subunit. requires formation multiprotein complex (VHLCBC)...
Background The pathogenesis of preeclampsia, a serious pregnancy disorder, is still elusive and its treatment empirical. Hypoxia Inducible Factor-1 (HIF-1) crucial for placental development early detection aberrant regulatory mechanisms HIF-1 could impact on the diagnosis management preeclampsia. HIF-1α stability controlled by O2-sensing enzymes including prolyl hydroxylases (PHDs), Factor Inhibiting HIF (FIH), E3 ligases Seven In Absentia Homologues (SIAHs). Here we investigated early-...
Considering that interleukin 10 (IL10), transforming growth factor beta1 (TGFB1), and interferon gamma (IFNG) are involved in the susceptibility of BeWo trophoblast cells to Toxoplasma gondii infection, aim present study was investigate effector mechanisms triggered by these cytokines control T. cells. For this purpose, infected/uninfected were treated with IL10, TGFB1 (50 ng/ml), IFNG (20 or 100 ng/ml) order verify phosphorylation signal transducers activators transcription 1 (STAT1),...
Macrophage migration inhibitory factor (MIF) was discovered as an activated T-lymphocyte-derived protein that inhibits the random of macrophages in vitro. Subsequently, knowledge physiological actions MIF extended to include its role a proinflammatory cytokine affects several functions and lymphocytes. Previous reports have suggested involvement reproduction. However, no data are currently available on presence this human endometrium. In study, expression tissue localization evaluated...
Macrophage migration inhibitory factor (MIF) is a cytokine produced by neuroendocrine and immune tissues that possesses several characteristics of mediator. Chronic pain known to affect be affected mechanisms. In the present study, plasma levels MIF hormones (cortisol, estradiol, testosterone) were determined evaluate their mutual behaviour in controls chronic patients. Blood samples collected from males females divided into groups depending on age (younger or older than 55) health...
para-Nonylphenol (p-NP) is a metabolite of alkylphenols widely used in the chemical industry and manufacturing. It accumulates environment, where it acts with estrogen-like activity. We previously showed that p-NP on human placenta by inducing trophoblast differentiation apoptosis.
The human endometrium is a fertility-determining tissue and target of steroid hormones' action. Endocrine disruptors (EDs) can exert adverse effects on the physiological function decidua at maternal–fetal interface. We examined potential an ED, bisphenol A (BPA), endometrial maturation/decidualization, receptivity, secretion decidual factors (biomarkers). In vitro decidualized, stromal cells from six hysterectomy specimens were treated with 1 pM–1 μM BPA, for 24 h assessed cell viability...
p-Nonylphenol (p-NP) is a metabolite of alkylphenol ethoxylates used as surfactants in the manufacturing industry. Although it reported to have estrogenic activity and be transferred from mother embryo, no data are available on its effects development human placenta. In present study, we investigated estrogen receptors' (ERs) expression first trimester Using an vitro model chorionic villous explants, then compared p-NP 17β-estradiol (17β-E2). Finally, trophoblast-derived choriocarcinoma cell...
This work aims to clarify the effect of dietary supplementation with Bisphenol A (BPA), a chemical widely present in beverage and food containers, on placental glucose transfer pregnancy outcome. The study was performed female Sprague Dawley rats fed diet containing BPA (2.5, 25 or 250 μg/Kg/day) for period month (virgin state) plus 20 days during pregnancy. Western blot analysis immunohistochemistry were tissues type 1 transporter (GLUT1). Furthermore, human trophoblast, HTR8-SV/neo cells,...
Macrophage migration inhibitory factor (MIF) is an important proinflammatory cytokine involved in regulation of macrophage function. In addition, MIF may also play a role murine and human reproduction. Although both first trimester trophoblast decidua express MIF, the functional significance this during placental development remains unclear. We assessed expression throughout normal development, as well vitro (chorionic villous explants) vivo (high altitude placentae) models hypoxia....
The proinflammatory cytokine MIF (macrophage migration inhibitory factor) is involved in physiological and pathological processes pregnancy. maternal serum levels are increased preeclampsia (PE). We hypothesize that pregnancy tissues the source of overexpression PE. protein was studied sera, placental tissues, fetal membranes, umbilical cord 8 control 20 PE pregnancies: 10 with normal growth (PE-AGA) restriction (PE-FGR). were significantly higher PE-AGA membranes than controls PE-FGR. In...