A5014446196- Indigenous Studies and Ecology
- Pharmacogenetics and Drug Metabolism
- Arctic and Russian Policy Studies
- Toxic Organic Pollutants Impact
- Drug Transport and Resistance Mechanisms
- Air Quality and Health Impacts
- Climate change and permafrost
- Climate Change and Health Impacts
- Health disparities and outcomes
- Effects and risks of endocrine disrupting chemicals
- Mercury impact and mitigation studies
- Eicosanoids and Hypertension Pharmacology
- Per- and polyfluoroalkyl substances research
- Indigenous Health, Education, and Rights
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease Diagnosis and Treatment
- Research in Social Sciences
- Carcinogens and Genotoxicity Assessment
- Zoonotic diseases and public health
- Health, Environment, Cognitive Aging
- Health, psychology, and well-being
- Vehicle emissions and performance
- Heavy Metal Exposure and Toxicity
- Food Security and Health in Diverse Populations
- Air Quality Monitoring and Forecasting
University of Oulu
2016-2025
University of the Arctic
2017-2024
University of Alberta
2024
Alaska Native Medical Center
2024
Northern (Arctic) Federal University
2024
Qaujigiartiit Health Research Centre
2024
University of Manitoba
2024
University of Sharjah
2023
Arctic Research Centre
2012-2018
International Institute for Applied Systems Analysis
2017
OBJECTIVE To investigate the effect of ginseng on newly diagnosed non-insulin-dependent diabetes mellitus (NIDDM) patients. RESEARCH DESIGN AND METHODS In this double-blind placebo-controlled study, 36 NIDDM patients were treated for 8 weeks with (100 or 200 mg) placebo. Efficacy was evaluated psychophysical tests and measurements glucose balance, serum lipids, aminoterminalpropeptide (PIIINP) concentration, body weight. RESULTS Ginseng therapy elevated mood, improved performance, reduced...

 Background: a major problem in evaluating and reviewing the published findings of studies on association between quantitative explanatory variable dependent is that results are analysed reported many different ways. To achieve an effective review studies, consistent presentation necessary. This paper aims to exemplify main topics related summarising pooling research from multivariable models with response variable.
 Methods: we outline complexities involved synthesising...
Pregnancy, infancy, and childhood are sensitive windows for environmental exposures. Yet the health effects of exposure to nano- microplastics (NMPs) remain largely uninvestigated or unknown. Although plastic chemicals a well-established research topic, impacts particles unexplored, especially with regard early life exposures.This commentary aims summarize knowns unknowns around child- pregnancy-relevant exposures NMPs via inhalation, placental transfer, ingestion breastmilk, dermal...
Arctic Monitoring and Assessment Programme (AMAP) monitors persistent organic pollutant (POP) levels in the populations assesses health effects related to exposure them. Many internationally regulated POPs persist humans biota, while new Emerging Contaminants of Concern (ECAC), many which are unregulated, present additional challenges. Biomonitoring offers valuable insights into temporal trends within human matrices, revealing critical information not only about efficacy international...
The polymorphic human cytochrome P450 2A6 (CYP2A6) metabolises a number of drugs, activates variety precarcinogens and constitutes the major nicotine C ‐oxidase. A relationship between CYP2A6 genotype smoking habits, as well incidence lung cancer, has been proposed. Two defective alleles have hitherto identified, one which is very common in Asian populations. Among Caucasians, an additional frequently distributed allele ( CYP2A6*3 ) suggested to play protective role against addiction...
A test designed to estimate the extent and rate of formation 7-hydroxycoumarin by measuring urinary excretion metabolite in humans after administering 5 mg coumarin was developed. Coumarin rapidly metabolized oral administration more than 95% 7OHC formed excreted 4 h. The total amount 64 +/- 15% (mean SD, variation 20-100%) dose given. percentage 2 h, as compared with found be a constant stable individual characteristic for ('2 h test'). In 110 volunteers, there great interindividual...
Cytochrome P450 2A6 (CYP2A6) is a polymorphic enzyme responsible for the oxidation of certain precarcinogens and drugs major nicotine C-oxidase. The role CYP2A6 elimination was emphasised recently by finding that smokers carrying defective alleles consumed fewer cigarettes [Pianezza et al. (1998) Nature 393, 750]. method used genotyping has, however, been found to give erroneous results with respect coumarin hydroxylase phenotype, probe reaction enzyme. present study describes an...
This study concerns the occurrence of various forms mistreatment by staff and fellow students experienced in Faculty Medicine other four faculties University Oulu, Finland.A questionnaire with 51 questions on physical psychological was distributed to 665 (451 females) after lectures or examinations filled returned. The results were analysed gender faculty. differences between males females assessed statistically using a test for equality two proportions. An exact two-sided P value calculated...
The human CYP2A6 enzyme metabolizes certain drugs and pre-carcinogens appears to be the most important for nicotine metabolism. At present, more than 10 different allelic variants are known that cause abolished or decreased activity. Genetic polymorphism in this gene might of particular importance an individual's need susceptibility lung and/or liver cancer. We have identified a new allele (CYP2A6*12) which carries unequal crossover between CYP2A7 genes intron 2. This results hybrid where 5′...
Summary: We evaluated liver P450 enzyme system induction and serum lipid levels in a prospective follow–up study 12 male patients with epilepsy after replacing carbamazepine (CBZ) medication oxcarbazepine (OCBZ). Antipyrine 1 1/2 increased antipyrine CL decreased 2 months the was changed, reflecting normalization of function. Furthermore, total cholesterol decreased, but concentrations high‐density lipoprotein (HDL)‐cholesterol triglycerides (TG) were unchanged. OCBZ may be preferable...
When an individual's socio-emotional needs are not being adequately met, the subjective and negative feeling of loneliness occurs. Study assessed experiences 16-year-olds in Northern Finland Birth Cohort 1986 (n=7014). Most (70.4%) adolescents reported lonely, 26.4% somewhat 3.2% very lonely. Girls more than boys. Multinomial logistic regression was employed to describe association selected social, emotional, contextual health well-being factors between lonely adolescents. All grouped as...
The major part of the attractiveness Nordic tourism relies on natural resources and features such as landscape, flora, fauna four seasons. Lately, it has been predicted that climate change will alter these preconditions nature-based destinations, which may have severe consequences for industry. Nevertheless, is also bound to many other societal changes influence economics development peripheral communities dependent bring new challenges in maintaining their vitality. For assessing potential...