A5053709982- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Immune Cell Function and Interaction
- Fungal Infections and Studies
- Macrophage Migration Inhibitory Factor
- Parasites and Host Interactions
- IL-33, ST2, and ILC Pathways
- Morinda citrifolia extract uses
- Oral microbiology and periodontitis research
- Immune Response and Inflammation
- Antifungal resistance and susceptibility
- Clinical Laboratory Practices and Quality Control
- Osteoarthritis Treatment and Mechanisms
- Pomegranate: compositions and health benefits
- Stress Responses and Cortisol
- Antibiotic Resistance in Bacteria
- Iron Metabolism and Disorders
- Muscle Physiology and Disorders
- Toxin Mechanisms and Immunotoxins
- Rheumatoid Arthritis Research and Therapies
- Viral gastroenteritis research and epidemiology
- Bioactive Compounds and Antitumor Agents
- Vibrio bacteria research studies
- Toxoplasma gondii Research Studies
- Child Nutrition and Water Access
Universidade Federal do Triângulo Mineiro
2016-2025
University of Córdoba
2022
Instituto Maimónides de Investigación Biomédica de Córdoba
2022
Instituto de Salud Carlos III
2022
Hospital Universitario Reina Sofía
2022
Municipality of Medellín
2013-2014
Clínica CES
2013
Acute lung injury (ALI) is characterized by alveolar edema and uncontrolled neutrophil migration to the lung, no specific therapy still available. Ellagic acid, a compound present in several fruits medicinal plants, has shown anti-inflammatory activity experimental disease models. We used nonlethal acid aspiration model of ALI mice determine whether preventive or therapeutic administration ellagic (10 mg/kg; oral route) could interfere with development establishment inflammation....
Cryptococcus neoformans is a life-threatening fungal pathogen that primarily affects immunocompromised individuals. While antiretroviral therapy has reduced incidence in developed nations, fluconazole-resistant strains and virulent environmental isolates continue to pose challenges, especially because they have many mechanisms of adaptability, supporting their survival. This study explores the phenetic metabolomic adaptations C. clinical contexts understand factors influencing pathogenicity...
Empirical and prolonged antimicrobial treatment of urinary tract infections caused by Escherichia coli is associated with the emergence bacterial resistance, not all countries have strict policies against indiscriminate use drugs in order to prevent resistance. This cross-sectional retrospective study (2010-2015) aimed evaluate sensitivity resistance patient-derived E. different broadly used treat Brazil: ampicillin + sulbactam, cephalothin, ciprofloxacin, norfloxacin, nitrofurantoin. We...
Strategies for obtaining reliable results are increasingly implemented in order to reduce errors the analysis of human and veterinary samples; however, further data required murine samples. Here, we determined an average factor from body surface area calculation biochemical renal parameters, assessed effects storage freeze-thawing C57BL/6 mouse samples on plasmatic urinary urea, evaluated using two different urea-measurement techniques. After 24 h urine samples, blood was collected, weight...
Chagas disease is caused by the protozoan Trypanosoma cruzi and characterized cardiac, gastrointestinal, nervous system disorders. Although much about pathophysiological process of already known, influence parasite burden on inflammatory progression remains uncertain. We used an acute experimental model to evaluate effect T. intestinal lesions assessed correlations between load inflammation injury at 7 14 days post-infection. Low (3 × 102), medium 103), high 104) loads were generated...
Chronic periodontitis is a multifactorial inflammatory disease that affects supporting structures of the teeth. Although gingival response largely described, little known about immune changes in alveolar bone and neighboring tissues could indicate periodontal (PD) activity. Then, this study we identified ongoing novel biomarkers for directly affected by destructive PD patients. Samples were collected osteotomy 17 control subjects during extraction third molars 18 patients with advanced PD,...
During infection, the host response develops effector mechanisms to combat parasite. However, this can become uncontrolled or regulated by that modulate inflammatory reaction. The number of parasites infects host, such as trypomastigotes in Chagas disease, may also influence immune activation and disease pathology. We evaluated inflammation regulation follows Trypanosoma cruzi infection with low (300), intermediate (3000) high (30000) parasite loads. Our results showed load inoculum...
Summary Current therapies for inflammatory bowel diseases (IBD) are aimed at controlling the exacerbated response in gut, but no treatment is fully effective many refractory patients. Mesenchymal stromal cells (MSC) multi-potent with regulatory immunosuppressive activity that may control diseases. In this study, we investigated short- and especially long-term protective effects of MSC on experimental colitis. We show elicited protection to acute intestinal inflammation gain weight,...
Asthma is a disease of airway inflammation characterized by hyperresponsiveness, eosinophilic inflammation, and hypersecretion mucus. Ellagic acid, compound derived from medicinal plants fruits, has shown anti-inflammatory activity in several experimental models. We used the classical model, BALB/c mice, sensibilization with ovalbumin to determine effect ellagic acid (10 mg/kg; oral route) resolution allergic airways response. Dexamethasone (1 subcutaneous was as positive control. The...
Background Chagas disease is a neglected tropical caused by Trypanosoma cruzi. Despite the vast number of studies evaluating pathophysiological mechanisms disease, influence parasite burden on kidney lesions remains unclear. Thus, main goal this work was to evaluate effect T. cruzi infection renal function and determine whether there correlation between load injury using an acute experimental model disease. Methodology/Principal Findings Low, medium high loads were generated infecting...
MIF is a pro-inflammatory cytokine that plays important roles in physiology, pathology, immunology and parasitology, including the control of infection by protozoa parasites such as Toxoplasma gondii. As function congenital toxoplasmosis not fully elucidated yet, present study brings new insights for T. gondii absence based on pregnant C57BL/6MIF-/- mouse models. Pregnant C57BL/6WT mice were infected with 05 cysts (ME49 strain) first day pregnancy (dop) euthanized at 8 dop. Non-pregnant...
Morinda citrifolia L. (noni) has been shown to treat different disorders. However, data concerning its role in the treatment of intestinal inflammation still require clarification. In current study, we investigated effects noni fruit juice (NFJ) C57BL/6 mice, which were continuously exposed dextran sulfate sodium (DSS) for 9 consecutive days. NFJ consumption had no impact on reduction clinical signs disease or weight loss. Nonetheless, when a dilution 1 : 10 was used, architecture mice...
Morinda citrifolia L. (noni) has been indicated to treat a variety of disorders; however, important aspects surrounding the consumption products derived from noni still require clarification. We investigated immune-related effects produced by fruit juice C57BL/6 mice. In intestine, IL-4 and IL-10 levels were reduced following at 1:100 dilution. However, when highest concentrations administered, IFN-γ, TNF-α IL-12 increased in this organ. Similarly, TNF-α, IL-12, IL-4, IL-23 liver. kidney,...
INTRODUÇÃO: Conhecer os parâmetros bioquímicos individuais de animais laboratório utilizados na experimentação é importante, pois eles servirão como para avaliar alterações funcionais em órgãos e base estabelecer valores referência. OBJETIVO:Estabelecer referência do sangue camundongos das linhagens BALB/c C57BL/6 selvagens Biotério da Disciplina Biologia Celular Universidade Federal Triângulo Mineiro (UFTM). Materiais métodos: Foram 30 (BALB/c selvagem). Os exames realizados foram glicose,...
The clinical benefits of short-term therapy with glucocorticoids (GC) in patients inflammatory bowel disease (IBD) are widely known. However, the effects this treatment towards re-establishment regulatory network IBD not fully explored. We have evaluated immunological abbreviated GC experimental colitis induced by 3% dextran sulphate sodium C57BL/6 mice. Treatment improved outcome, constrained circulating leucocytes and ameliorated intestinal inflammation. control local responses involved a...
The current therapeutic options for Inflammatory Bowel Diseases (IBD) are limited. Even using common anti-inflammatory, immunosuppressive or biological therapies, many patients become unresponsive to the treatments, immunosuppressed unable restrain secondary infections. Statins cholesterol-lowering drugs with non-canonical anti-inflammatory properties, whose underlying mechanisms of action still remain poorly understood. Here, we described that
This report describes a 32-year-old male AIDS patient. He presented with clinical picture characterized by severe headache, blurred vision, and fever that had lasted for 10 days. At admission, no remarkable neurologic abnormalities were observed. Cranial tomography showed ring-enhanced lesion edema mass effect in the right occipital lobe. The initial diagnosis was toxoplasmosis, treatment of this administered. However, 5 days later, patient’s status worsened he died. necropsy necrotizing...
Toll-like receptors (TLR) contain N-glycans, which are important glycotargets for plant lectins, to induce immunomodulation. The lectin ArtinM obtained from Artocarpus heterophyllus interacts with TLR2 N-glycans stimulate IL-12 production by antigen-presenting cells and drive the immune response toward Th1 axis, conferring resistance against intracellular pathogens. This immunomodulatory effect was demonstrated subcutaneously injecting (s.c.) (0.5 μg) in infected mice. In this study, we...
A morphometric study of the circular colon musculature was performed, in which mast cell count determined and connective fibrous tissue this layer measured. The objective to gain better understanding Chagas megacolon morphology contribute towards knowledge fibrosis pathogenesis megas. An evaluation made 15 distal sigmoid rings from patients with (MCC), without (CSMC) non-Chagas (NC). were fixed formol, embedded paraffin, 7mm thick sections cut stained using Azan-Heidenhain Giemsa. greater...