A5021302877- Immune Cell Function and Interaction
- Sirtuins and Resveratrol in Medicine
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Muscle Physiology and Disorders
- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- Gut microbiota and health
- Cytomegalovirus and herpesvirus research
- Amyotrophic Lateral Sclerosis Research
- Calcium signaling and nucleotide metabolism
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Dietary Effects on Health
- Blood disorders and treatments
- Histone Deacetylase Inhibitors Research
- Neurogenetic and Muscular Disorders Research
- Single-cell and spatial transcriptomics
- Renal Transplantation Outcomes and Treatments
- Restless Legs Syndrome Research
- Adenosine and Purinergic Signaling
- Zebrafish Biomedical Research Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Neurological diseases and metabolism
- Helicobacter pylori-related gastroenterology studies
Friedrich-Alexander-Universität Erlangen-Nürnberg
2025
Universitätsklinikum Erlangen
2025
Universidade de São Paulo
2017-2024
Institute of Biomedical Science
2021
Gastrointestinal (GI) dysfunction emerges years before motor symptoms in Parkinson′s disease (PD), implicating the enteric nervous system (ENS) early progression. However, mechanisms linking PD hallmark protein, α-synuclein (α-syn), to ENS - and whether these are influenced by inflammation remains elusive. Using iPSC-derived neural lineages from patients with α-syn triplications, we reveal that TNF-α increases mitochondrial-α-syn interactions, disrupts malate-aspartate shuttle, forces a...
Objective Astrocytes play a significant role in the pathology of multiple sclerosis (MS). Nevertheless, for ethical reasons, most studies these cells were performed using Experimental Autoimmune Encephalomyelitis model. As there are differences between human and mouse cells, we aimed here to better characterize astrocytes from patients with MS (PwMS), focusing mainly on mitochondrial function cell metabolism. Methods We obtained characterized induced pluripotent stem (iPSC)‐derived three...
The current therapeutic options for Inflammatory Bowel Diseases (IBD) are limited. Even using common anti-inflammatory, immunosuppressive or biological therapies, many patients become unresponsive to the treatments, immunosuppressed unable restrain secondary infections. Statins cholesterol-lowering drugs with non-canonical anti-inflammatory properties, whose underlying mechanisms of action still remain poorly understood. Here, we described that
Seminal works have now revealed the gut microbiota is connected with several diseases, including renal disorders. The balance between optimal and dysregulated host-microbiota interactions has completely changed our understanding of immunity inflammation. Kidney injury associated accumulation uremic toxins in intestine, augmented intestinal permeability, systemic Intestinal bacteria can signal through innate receptors induce immune cell activation lamina propria release inflammatory mediators...
Little is known about the diversity in immune profile of different wild type strains zebrafish (Danio rerio), despite its growing popularity as an animal model to study human diseases and drug testing. In case data resulting from modeling diseases, differences background Danio fishes have rarely been taken into consideration when interpreting results this potentially problematic, many studies not even mention source strain animals. study, we hypothesized that could present distinct traits....
Abstract Sirtuin 1 (SIRT1) is a class III histone deacetylase (HDAC3) that plays crucial role in regulating the activation and differentiation of dendritic cells (DCs) as well controlling polarization T cells. Obesity, chronic inflammatory condition, characterized by immune various tissues. We hypothesized SIRT1 might influence phenotype functions DCs through Ido1 pathway, ultimately leading to towards pro-inflammatory obesity. In our study, we observed activity was reduced bone...
The mammalian target of rapamycin (mTOR) pathway plays a key role in determining immune cells function through modulation their metabolic status. By specific deletion Rictor CD11c+ myeloid (referred to here as CD11cRicΔ/Δ), we investigated the mTOR complex 2 (mTORC2) signaling dendritic (DCs) mice. We showed that upon dextran sulfate sodium-induced colitis, lack mTORC2 diminishes colitis score and abrogates DC migration mesenteric lymph nodes, thereby diminishing infiltration T helper 17...
<title>Abstract</title> Sirtuin 1 (SIRT1) is a class III histone deacetylase (HDAC3) that plays crucial role in regulating the activation and differentiation of dendritic cells (DCs) as well controlling polarization T cells. Obesity, chronic inflammatory condition, characterized by immune various tissues. We hypothesized SIRT1 might influence phenotype functions DCs through Ido1 pathway, ultimately leading to towards proinflammatory obesity. In our study, we observed activity was reduced...
Sepsis is a complex infectious syndrome in which neutrophil participation crucial for patient survival. Neutrophils quickly sense and eliminate the pathogen by using different effector mechanisms controlled metabolic processes. The mammalian target of rapamycin (mTOR) pathway an important route regulation, its role metabolism has not been fully understood yet, especially importance mTOR 2 (mTORC2) functions. In this study, we observed that loss Rictor (mTORC2 scaffold protein) primary...
ABSTRACT Objective Astrocytes play a significant role in the pathology of Multiple Sclerosis (MS). Nevertheless, for ethical reasons, most studies these cells were performed on Experimental Autoimmune Encephalomyelitis model. As there are differences between human and mouse cells, we aimed here to better characterize astrocytes from patients with MS (PwMS), focusing mainly mitochondrial function cell metabolism. Methods We obtained characterized induced pluripotent stem (iPSC)-derived three...
Abstract Mammalian target of rapamycin (mTOR) pathway plays a key role in determining immune cells function through modulation their metabolic status. By specific deletion Rictor tissue-resident CD11c + myeloid (CD11cRic Δ/Δ ), this study investigated the mTOR complex 2 (mTORC2) signaling dendritic (DCs) mice. We showed that upon DSS-induced colitis, lack mTORC2 diminish colonic inflammation, abrogates cell (DC) migration to mesenteric lymph nodes (MLN), thereby diminishing infiltration T...