A5046596875- Thermal Regulation in Medicine
- Respiratory Support and Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Response and Inflammation
- Adipose Tissue and Metabolism
- Neuroscience of respiration and sleep
- Sepsis Diagnosis and Treatment
- Immune cells in cancer
- Inflammatory Bowel Disease
- Eosinophilic Esophagitis
- Wound Healing and Treatments
- Metabolomics and Mass Spectrometry Studies
- High Altitude and Hypoxia
- Autoimmune and Inflammatory Disorders Research
- Mosquito-borne diseases and control
- Regulation of Appetite and Obesity
- Dietary Effects on Health
- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Gastrointestinal motility and disorders
- Renal function and acid-base balance
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Dermatology and Skin Diseases
- Inflammasome and immune disorders
- Blood disorders and treatments
Universidade de São Paulo
2014-2021
Institute of Biomedical Science
2021
Universidade Federal do Triângulo Mineiro
2017-2019
Universidade de Ribeirão Preto
2017-2019
Universidade Brasil
2014
We tested the hypothesis that development of hypothermia instead fever in endotoxic shock is consequential to hypoxia. Endotoxic was induced by bacterial lipopolysaccharide (LPS, 500 μg kg(-1) i.v.) rats at an ambient temperature 22 °C. A β3-adrenergic agonist known activate metabolic heat production, CL316,243, employed evaluate whether thermogenic capacity could be impaired fall oxygen delivery (ḊO2) during shock. This possibility rejected as CL316,243 (0.15 mg evoked similar rises...
Hypothermia in sepsis is generally perceived as something dysregulated and progressive although there has been no assessment on the natural course of this phenomenon humans. This was first study dynamics hypothermia septic patients not subjected to active rewarming, results were surprising. A sample 50 subjects presenting with spontaneous during drawn from 2005-2012 database an academic hospital. defined body temperature below 36.0°C for longer than 2 h, at least one reading 35.5°C or less....
Spleen-derived LTB 4 primes liver cells to generate the proinflammatory cytokine TNF during systemic inflammation.
Summary Current therapies for inflammatory bowel diseases (IBD) are aimed at controlling the exacerbated response in gut, but no treatment is fully effective many refractory patients. Mesenchymal stromal cells (MSC) multi-potent with regulatory immunosuppressive activity that may control diseases. In this study, we investigated short- and especially long-term protective effects of MSC on experimental colitis. We show elicited protection to acute intestinal inflammation gain weight,...
To elucidate the role of leptin in acute systemic inflammation, we investigated how its infusion at low, physiologically relevant doses affects responses to bacterial lipopolysaccharide (LPS) rats subjected 24 h food deprivation. Leptin was infused subcutaneously (0-20 μg·kg-1·h-1) or intracerebroventricularly (0-1 μg·kg-1·h-1). Using hypothermia and hypotension as biomarkers identified phase extending from 90 240 min post-LPS most susceptible modulation by leptin. In this phase, suppressed...
The mechanisms by which obesity may alter immune responses to pathogens are poorly understood. present study assessed whether the intrinsic responsiveness of resident macrophages bacterial lipopolysaccharide (LPS) is reprogrammed in high-fat diet (HFD)-induced obesity. Macrophages from adipose tissue, lung alveoli and peritoneal cavity were extracted obese rats on a HFD or their lean counterparts, subsequently studied culture under identical conditions. CD45+/CD68+ cells (macrophages)...
This study introduces the respiratory exchange ratio (RER; of whole-body CO2 production to O2 consumption) as an aid monitor metabolic acidosis during early phase endotoxic shock in unanesthetized, freely moving rats. Two serotypes lipopolysaccharide (lipopolysaccharide [LPS] O55:B5 and O127:B8) were tested at shock-inducing doses (0.5–2 mg/kg). Phasic rises RER observed consistently across LPS doses. The rise often exceeded ceiling quotient for oxidative metabolism, was mirrored by...
During the feeding process, mouthparts of hematophagous mosquitoes break skin barrier and probe host tissue to find blood. The saliva inoculated in this microenvironment modulates hemostasis, inflammation adaptive immune responses. However, mechanisms involved these biological activities remain poorly understood few studies explored potential roles mosquito on individual cellular components system. Here, we report immunomodulatory Aedes aegypti salivary cocktail murine peritoneal...
Life-threatening infections (sepsis) are usually associated with co-morbidities, among which obesity deserves attention. Here, we evaluated whether and how affects the switch from fever to hypothermia that occurs in most severe cases of sepsis, is thought provide physiological support for a change host defense strategy resistance tolerance. Obesity was induced by keeping rats on high-fat diet 32–34 weeks. The high dose bacterial lipopolysaccharide (LPS, 300 μg/animal, i.a.) attenuated obese...
Sepsis is a complex infectious syndrome in which neutrophil participation crucial for patient survival. Neutrophils quickly sense and eliminate the pathogen by using different effector mechanisms controlled metabolic processes. The mammalian target of rapamycin (mTOR) pathway an important route regulation, its role metabolism has not been fully understood yet, especially importance mTOR 2 (mTORC2) functions. In this study, we observed that loss Rictor (mTORC2 scaffold protein) primary...
Oxygen utilization (VO 2 ) is thought to fall in the late stages of septic shock because mitochondrial dysfunction, circulatory hypoxia or both. However, applicability this conceptual framework early unclear. We investigated matter a rat model lipopolysaccharide (LPS)‐induced (endotoxic shock). A novel experimental preparation was devised simultaneously monitor oxygen delivery (DO and VO rats whose thermoregulation had not been disrupted by anesthetics. Using β 3 ‐adrenergic agonist known...