A5110218648- Biochemical effects in animals
- Inflammasome and immune disorders
- Vagus Nerve Stimulation Research
- Essential Oils and Antimicrobial Activity
- Sepsis Diagnosis and Treatment
- Pharmacological Effects of Medicinal Plants
- Renal function and acid-base balance
- Liver Disease Diagnosis and Treatment
- Biochemical Analysis and Sensing Techniques
- Pharmacological Effects of Natural Compounds
- Metabolomics and Mass Spectrometry Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Heart Rate Variability and Autonomic Control
- Endoplasmic Reticulum Stress and Disease
- Hemodynamic Monitoring and Therapy
- Probiotics and Fermented Foods
- Neuroscience of respiration and sleep
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Regulation of Appetite and Obesity
- Phytochemistry and Biological Activities
- Dietary Effects on Health
- Galectins and Cancer Biology
- Ethnobotanical and Medicinal Plants Studies
- Respiratory Support and Mechanisms
Universidade Federal de Minas Gerais
2024-2025
Vanderbilt University Medical Center
2025
Universidade de São Paulo
2017-2023
Universidade Federal do Piauí
2013-2015
Spleen-derived LTB 4 primes liver cells to generate the proinflammatory cytokine TNF during systemic inflammation.
The liver serves as a major energetic reservoir for other tissues and its metabolic function is controlled by humoral neural factors. vagus nerve innervating the gastrointestinal tract plays an important role in regulating peripheral metabolism energy expenditure. Although receives fibers, impact of this circuitry regulation hepatic still poorly understood. Herein, we used combination quantitative proteomics vivo imaging techniques to investigate on male mice. Liver-brain axis was impaired...
In addition to individual genetics, environmental factors (e.g., dietary changes) may influence host susceptibility gastrointestinal infection through unknown mechanisms. Herein, we developed a model in which CBA/J mice, genetically resistant strain that tolerates intestinal colonization by the enteric pathogen Salmonella Typhimurium (S. Tm), rapidly succumb after exposure diet rich L-amino acids (AA). S. Tm-gastroenteritis is restricted large intestine (cecum), limiting their use understand...
Introduction Guanylate-binding proteins (GBPs) are produced in response to pro-inflammatory signals, mainly interferons. The most studied cluster of GBPs mice is on chromosome 3. It comprises the genes for GBP1-to-3, GBP5 and GBP7. In humans, all present a single 1. Brucella abortus Gram-negative bacterium known cause brucellosis, debilitating disease that affects both humans animals. Our group demonstrated previously murine 3 (GBPchr3) important disrupt Brucella-containing vacuole itself...
To elucidate the role of leptin in acute systemic inflammation, we investigated how its infusion at low, physiologically relevant doses affects responses to bacterial lipopolysaccharide (LPS) rats subjected 24 h food deprivation. Leptin was infused subcutaneously (0-20 μg·kg-1·h-1) or intracerebroventricularly (0-1 μg·kg-1·h-1). Using hypothermia and hypotension as biomarkers identified phase extending from 90 240 min post-LPS most susceptible modulation by leptin. In this phase, suppressed...
This study introduces the respiratory exchange ratio (RER; of whole-body CO2 production to O2 consumption) as an aid monitor metabolic acidosis during early phase endotoxic shock in unanesthetized, freely moving rats. Two serotypes lipopolysaccharide (lipopolysaccharide [LPS] O55:B5 and O127:B8) were tested at shock-inducing doses (0.5–2 mg/kg). Phasic rises RER observed consistently across LPS doses. The rise often exceeded ceiling quotient for oxidative metabolism, was mirrored by...
Uncontrolled vasodilation is known to account for hypotension in the advanced stages of sepsis and other systemic inflammatory conditions, but mechanisms earlier such conditions are not clear. By monitoring hemodynamics with highest temporal resolution unanesthetized rats, combination ex-vivo assessment vascular function, we found that early development following injection bacterial lipopolysaccharide brought about by a fall resistance when arterioles still fully responsive vasoactive...
Abstract Background The liver serves as a major energetic reservoir for other tissues and its metabolic function is controlled by humoral neural factors. vagus nerve innervating the gastrointestinal tract plays an important role in regulating peripheral metabolism energy expenditure. Although receives fibers, impact of this circuitry regulation hepatic still poorly understood. Methods Herein, we used combination quantitative proteomics vivo imaging techniques to investigate on metabolism....