A5003129190- Mesenchymal stem cell research
- Pancreatic function and diabetes
- Wound Healing and Treatments
- Periodontal Regeneration and Treatments
- Cancer Cells and Metastasis
- Pluripotent Stem Cells Research
- Electrospun Nanofibers in Biomedical Applications
- Diabetes Treatment and Management
- 3D Printing in Biomedical Research
- Hematological disorders and diagnostics
- Silk-based biomaterials and applications
- Diabetes and associated disorders
- Immune cells in cancer
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Tissue Engineering and Regenerative Medicine
- IL-33, ST2, and ILC Pathways
- Hematopoietic Stem Cell Transplantation
- Metabolism, Diabetes, and Cancer
- Peptidase Inhibition and Analysis
- Burn Injury Management and Outcomes
- Neonatal Respiratory Health Research
SUPERA Park of Innovation and Technology of Ribeirão Preto
2019-2023
Nova Southeastern University
2020
Universidade Estadual de Campinas (UNICAMP)
2020
California Institute for Regenerative Medicine
2020
Universidade de São Paulo
2012-2019
Universidade de Ribeirão Preto
2019
Fundação de Amparo à Pesquisa do Estado de São Paulo
2016
A balance between proinflammatory (Th17 and Tc17) anti-inflammatory (regulatory T cells) subsets of cells is essential to maintain immunological tolerance prevent the onset several autoimmune diseases, including type 1 diabetes. However, kinetics these disease severity during streptozotocin (STZ)-induced diabetes course has not been determined. Thus, susceptible C57BL/6 mice were administrated with multiple low doses STZ we evaluated frequency/absolute number cell in pancreatic lymph nodes...
Major skin burns are difficult to treat. Patients often require special care and long-term hospitalization. Besides specific complications associated with the wounds themselves, there may be impairment of immune system other organs. Mesenchymal stromal cells (MSCs) a recent therapeutic alternative treat burns, mainly aiming accelerate healing process. Several MSC properties favor their use as approach, they promote angiogenesis, stimulate regeneration, enhance immunoregulatory function....
The association between tridimensional scaffolds to cells of interest has provided excellent perspectives for obtaining viable complex tissues in vitro, such as skin, resulting impressive advances the field tissue engineering applied regenerative therapies. use multipotent mesenchymal stromal treatment dermo-epidermal wounds is particularly promising due several relevant properties these cells, high capacity proliferation culture, potential differentiation multiple skin cell types, important...
Abstract Introduction Mesenchymal stromal/stem cells (MSCs) are multipotent that have the ability to express and secrete a wide range of immunomodulatory molecules, cytokines, growth factors antiapoptotic proteins. MSCs modulate both innate adaptive immune responses making them potential candidates for treatment patients with type 1 diabetes mellitus (T1D). However, one problem frequently associated systemic administration is entrapment mainly in lungs. In this sense, trying avoid lung...
Diabetes mellitus (DM) is a chronic disease and major cause of mortality morbidity worldwide. The hyperglycemia caused by DM induces micro macrovascular complications that lead, among other consequences, to wounds amputations. Cell therapy tissue engineering constitute recent therapeutic alternatives improve wound healing in diabetic patients. current study aimed analyze the effectiveness biocuratives containing human mesenchymal stem cells (MSCs) associated with hydrogel matrix process...
Abstract Background Type 1 diabetes mellitus (T1D) is characterized by autoimmune responses resulting in destruction of insulin-producing pancreatic beta cells. Multipotent mesenchymal stromal cells (MSCs) exhibit immunomodulatory potential, migratory capacity to injured areas and may contribute tissue regeneration the secretion bioactive factors. Therefore, MSCs are considered as a promising approach treat patients with different diseases (AID), including T1D patients. Phenotypical...
Summary Current therapies for inflammatory bowel diseases (IBD) are aimed at controlling the exacerbated response in gut, but no treatment is fully effective many refractory patients. Mesenchymal stromal cells (MSC) multi-potent with regulatory immunosuppressive activity that may control diseases. In this study, we investigated short- and especially long-term protective effects of MSC on experimental colitis. We show elicited protection to acute intestinal inflammation gain weight,...