A5025284228- Fibroblast Growth Factor Research
- Eosinophilic Disorders and Syndromes
- PI3K/AKT/mTOR signaling in cancer
- Lung Cancer Treatments and Mutations
- Kruppel-like factors research
- Advanced Breast Cancer Therapies
- Plant tissue culture and regeneration
- Potato Plant Research
- Plant Disease Resistance and Genetics
- Geriatric Care and Nursing Homes
- Plant Pathogens and Resistance
- Herbal Medicine Research Studies
- Colorectal Cancer Treatments and Studies
- Epigenetics and DNA Methylation
- Seed Germination and Physiology
- Intergenerational Family Dynamics and Caregiving
- Transgenic Plants and Applications
- Genetics and Neurodevelopmental Disorders
- Plant Virus Research Studies
- Cocoa and Sweet Potato Agronomy
- Advanced Data Storage Technologies
- Plant Pathogens and Fungal Diseases
- Nematode management and characterization studies
- Plant and soil sciences
- Photosynthetic Processes and Mechanisms
Universidad de Costa Rica
1987-2024
Relay Therapeutics (United States)
2023-2024
European Organization for Nuclear Research
2019-2024
Office of Science
2022
United States Food and Drug Administration
2022
Sage Therapeutics (United States)
2021
National Center for Health Statistics
2013-2018
Harvard University
2016-2017
Howard Hughes Medical Institute
2016
Centers for Disease Control and Prevention
2006-2016
Abstract Oncogenic activation of fibroblast growth factor receptor 2 (FGFR2) drives multiple cancers and represents a broad therapeutic opportunity, yet selective targeting FGFR2 has not been achieved. Although the clinical efficacy pan-FGFR inhibitors (pan-FGFRi) validates driver status in fusion–positive intrahepatic cholangiocarcinoma, their benefit is limited by incomplete target coverage due to FGFR1- FGFR4-mediated toxicities (hyperphosphatemia diarrhea, respectively) emergence...
Fibroblast growth factor receptor (FGFR) kinase inhibitors have been shown to be effective in the treatment of intrahepatic cholangiocarcinoma and other advanced solid tumors harboring FGFR2 alterations, but toxicity these drugs frequently leads dose reduction or interruption such that maximum efficacy cannot achieved. The most common adverse effects are hyperphosphatemia caused by FGFR1 inhibition diarrhea due FGFR4 inhibition, as current therapies not selective among FGFRs. Designing has...
PIK3CA (PI3Kα) is a lipid kinase commonly mutated in cancer, including ∼40% of hormone receptor-positive breast cancer. The most frequently observed mutants occur the and helical domains. Orthosteric PI3Kα inhibitors suffer from poor selectivity leading to undesirable side effects, prominently hyperglycemia due inhibition wild-type (WT) PI3Kα. Here, we used molecular dynamics simulations cryo-electron microscopy identify an allosteric network that provides explanation for how mutations favor...
Objectives To estimate infection prevalence and explore associated risk factors in nursing home ( NH ) residents, individuals receiving health care HHC ), hospice care. Design Cross‐sectional. Setting Nationally representative samples of 1,174 U.S. s the 2004 N ational ursing H ome S urvey NNHS 1,036 agencies 2007 ospice C are NHHCS ). Participants A nationally sample 12,270 4,394 , 4,410 Measurements International Classification Diseases, Ninth Revision, Clinical Modification codes were...
The heterotetrameric Ndc80 complex establishes connectivity along the principal longitudinal axis of a kinetochore. Its two heterodimeric subcomplexes, each with globular end and coiled-coil shaft, connect end-to-end to create ∼600 Å long rod spanning gap from centromere-proximal structures spindle microtubules. Neither subcomplex has known function on its own, but organization characteristics junction are conserved yeast man. We have determined crystal shortened ("dwarf") complexes that...
Summary Arabidopsis thaliana was transformed with the codA gene from Arthrobacter globiformis , which encodes choline oxidase, enzyme that synthesizes glycinebetaine choline. The transformation enabled plants to accumulate in chloroplasts, and significantly enhanced freezing tolerance of plants. Furthermore, photosynthetic machinery more tolerant stress than wild‐type Exogenous application also increased plants, suggesting presence had their ability tolerate stress. Northern blotting...
The design of protein-peptide interactions has a wide array practical applications and also reveals insight into the basis for molecular recognition. Here, we present redesign tetratricopeptide repeat (TPR) protein scaffold, along with its corresponding peptide ligand. We show that binding properties these pairs can be understood, quantitatively, using straightforward chemical considerations. recognition have developed are practically useful specific identification tagged proteins....
Abstract FGFR2 fusions, amplifications, and mutations are oncogenic drivers that occur across multiple tumor types. Clinical efficacy observed with pan-FGFR inhibitors has validated the driver status of in fusion-positive intrahepatic cholangiocarcinoma (ICC), however, FGFR1-mediated toxicities (hyperphosphatemia, tissue mineralization) emergence on-target resistance limit inhibitors. To overcome these limitations, we designed RLY-4008, a potent highly selective, inhibitor. Despite...
The US population aged 65 and older is projected to double from 46 million 98 by 2060. While many Americans receive care family caregivers, the number of users paid, regulated long-term services, including adult day, residential care, nursing homes, home health, hospice, continues rise. Using data 2016 National Study Long-Term Care Providers conducted Center for Health Statistics, this poster provides a descriptive overview characteristics sector. state-level estimates are presented on...
Solanum commersonii es una especie silvestre de papa considerada como fuente genes resistencia al PVX. Para identificar marcadores moleculares relacionados con los a este virus, se realizó un análisis en el que combinó la técnica BSA uso AFLPs. Del cruce 2 padres heterocigotos y resistentes PVX, provenientes F1, obtuvo F2. La población fue inoculada PVXMS 30 días después mediante ELISA, progenie dividida individuos infectados no PVXMS; estos grupos les BSA. El ADN mezclado aparte del...
Simon Jenni1, Yoana N. Dimitrova1,2, Roberto Valverde1,3, Stephen M. Hinshaw1,2 and C. Harrison1,2 1Department of Biological Chemistry Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115 2Howard Hughes Institute, Correspondence: harrison{at}crystal.harvard.edu ↵3 Present address: Relay Therapeutics, Cambridge, 02142
Using the National Home and Hospice Care Surveys, we examined trends in length of hospice care from 1996 to 2007 factors associated with 2007. Results suggest that increasing average lengths over time reflect increase longest duration care. For-profit ownership is received for a year.
CERNBox is the CERN cloud storage hub. It allows synchronizing and sharing files on all major desktop mobile platforms (Linux, Windows, MacOSX, Android, iOS) aiming to provide universal access offline availability any data stored in EOS infrastructure. With more than 16000 users registered system, has responded high demand our diverse community an easily accessible solution that also provides integration with other services for big science: visualization tools, interactive analysis real-time...