A5051978017- Nutritional Studies and Diet
- Diet and metabolism studies
- Coenzyme Q10 studies and effects
- Advanced Glycation End Products research
- Diet, Metabolism, and Disease
- Cardiovascular Health and Disease Prevention
- Gut microbiota and health
- Advanced battery technologies research
- Liver Disease Diagnosis and Treatment
- Antioxidant Activity and Oxidative Stress
- Biochemical effects in animals
- Cardiovascular Disease and Adiposity
- Fatty Acid Research and Health
- Biochemical Acid Research Studies
- Metabolomics and Mass Spectrometry Studies
- Telomeres, Telomerase, and Senescence
- Peripheral Artery Disease Management
- Lipoproteins and Cardiovascular Health
- Nutrition and Health in Aging
- Metabolism, Diabetes, and Cancer
- Consumer Attitudes and Food Labeling
- Cancer, Lipids, and Metabolism
- Tea Polyphenols and Effects
- Oral microbiology and periodontitis research
- Health, psychology, and well-being
University of Córdoba
2010-2025
Instituto Maimónides de Investigación Biomédica de Córdoba
2010-2025
Instituto de Salud Carlos III
2010-2025
Hospital Universitario Reina Sofía
2010-2025
Surgical Science (Sweden)
2025
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2018-2024
Centro de Investigación Biomédica en Red
2018-2024
Sofia University
2021
Centre Hospitalier Saint-Nazaire
2021
University of Catania
2021
Ageing is an important determinant of atherosclerosis development rate, mainly by the creation a chronic low-grade inflammation. Diet, and particularly its fat content, modulates inflammatory response in fasting postprandial states. Our aim was to study effects dietary on expression genes related inflammation (NF-κB, monocyte chemoattractant protein 1 ( MCP-1 ), TNF-α IL-6 ) plaque stability (matrix metalloproteinase 9, MMP-9 during state twenty healthy, elderly people who followed three...
Background Endothelial dysfunction is a crucial step in atherosclerosis development, and its severity determinant for the risk of cardiovascular recurrence. Diet may be an effective strategy to protect endothelium, although there no consensus about best dietary model. The CORonary Intervention with Olive oil PREVention (CORDIOPREV) study ongoing prospective, randomized, single-blind, controlled trial 1,002 coronary heart disease (CHD) patients, whose primary objective compare effect 2...
Background and Purpose: Lifestyle diet affect cardiovascular risk, although there is currently no consensus about the best dietary model for secondary prevention of disease. The CORDIOPREV study (Coronary Diet Intervention With Olive Oil Cardiovascular Prevention) an ongoing prospective, randomized, single-blind, controlled trial in 1002 coronary heart disease patients, whose primary objective to compare effect 2 healthy patterns (low-fat rich complex carbohydrates versus Mediterranean extra...
Abstract Background Cardiovascular diseases (CVD), including coronary heart disease (CHD), display a higher prevalence in men than women. This study aims to evaluate the variations intestinal microbiota between and women afflicted with CHD delineate these against non-CVD control group for each sex. Methods Our research was conducted framework of CORDIOPREV study, clinical trial which involved 837 165 CHD. We contrasted our findings reference 375 individuals (270 men, 105 women) without CVD....
We have investigated whether the quality of dietary fat and supplementation with coenzyme Q10 (CoQ) modifies expression genes related inflammatory response endoplasmic reticulum stress in elderly persons. Twenty participants received three diets for 4 weeks each: Mediterranean diet + CoQ (Med CoQ), (Med), saturated fatty acid–rich (SFA). After 12-hour fast, volunteers consumed a breakfast composition similar to that each diets. Med produced lower fasting calreticulin, IL-1b, JNK-1 gene...
Abstract Background Telomere Length (TL), a marker of cellular aging, holds promise as biomarker to elucidate the molecular mechanism diabetes. This study aimed investigate whether shorter telomeres are associated with higher risk type 2 diabetes mellitus (T2DM) incidence in patients coronary heart disease; and determine most suitable dietary patterns, particularly Mediterranean diet or low-fat diet, can mitigate development these after follow-up period five years. Methods The CORonary Diet...
Scope It is hypothesized that decreased advanced glycation end products (AGEs) levels could affect type 2 diabetes mellitus (T2DM) remission in newly diagnosed patients through the consumption of two healthy diets. Methods and Results Patients from CORDIOPREV study, all with previous cardiovascular events, T2DM at beginning study are included. randomized to a Mediterranean or low‐fat diet for five years. No different rates found among Serum methylglioxal (MG) carboximethyllysine (CML),...
Endothelial dysfunction and intima-media thickness of common carotid arteries (IMT-CC) are considered subclinical markers atherosclerotic cardiovascular disease (ASCVD). Advanced glycation end products (AGEs) increased in type 2 diabetes mellitus (T2DM) patients, compared with non-diabetics, being implicated micro- macrovascular complications. Our aim was to compare serum AGEs levels between patients established newly diagnosed T2DM. Among 540 T2DM coronary heart from the CORDIOPREV study,...
Recent evidence links diet and physical activity with type 2 diabetes mellitus (T2DM) remission, but emerging findings suggest that immune system dysregulation may play a crucial role. This study aimed to investigate the associations between neutrophils T2DM remission. We conducted comprehensive analysis of newly-diagnosed patients (N = 183) from CORDIOPREV study, without glucose-lowering treatment, were randomized follow either Mediterranean or low-fat diet. Patients classified into two...
Abstract Background and Aims Preventing new cardiovascular events in patients with established disease (CVD) is a daunting task for clinicians. Intestinal microbiota may help identify at risk, thus improving the strategies of secondary prevention. The aim this study was to evaluate baseline differences between gut from coronary heart (CHD) suffering major adverse (MACEs) following 7 years, compared CHD who did not undergo MACE period, build score associated risk MACE. Methods Within...
Abstract Scope: Dysfunctional adipose tissue may be an important trigger of molecular inflammatory pathways that cause cardiovascular diseases. Our aim was to determine whether the specific quality and quantity dietary fat produce differential postprandial responses in from metabolic syndrome (MetS) patients. Methods results: A randomized, controlled trial conducted within LIPGENE study assigned MetS patients 1 4 diets: (i) high‐saturated fatty acid (HSFA), (ii) high‐monounsaturated (HMUFA),...
The search for vegetable-origin probiotic microorganisms is a recent area of interest. This study conducted phase I clinical trial to assess the effects oral administration Lactiplantibacillus pentosus LPG1, natural strain with potential isolated from table olive fermentations, on gut microbiota. was randomised, placebo-controlled, single-blind involving 39 healthy volunteers. Group A (n = 20) ingested one capsule/day L. LPG1 containing 1 × 1010 UFC/capsule, while B 19) received only...
Type 2 diabetes mellitus (T2DM) is recognized an independent risk factor for chronic kidney disease (CKD). The precise contribution and differential response to treatment strategies reduce dysfunction, depending on whether obesity present alongside T2DM or not, remain be fully clarified. Our objective was improve our understanding of how contributes function in patients with coronary heart (CHD), who are highly predisposed CKD, assign the most effective dietary approach preserve function.
Abstract We demonstrate unequivocally that defective cholesterol synthesis is an independent determinant of liver inflammation and fibrosis. prepared a mouse hepatocyte-specific knockout (LKO) lanosterol 14α-demethylase (CYP51) from the part already committed to cholesterol. LKO mice developed hepatomegaly with oval cell proliferation, fibrosis inflammation, but without steatosis. The key trigger was reduced esters provoked cycle arrest, senescence-associated secretory phenotype ultimately...
Abstract Purpose Diabetes remission is a phenomenon described in the context of drastic weight loss due to bariatric surgery or low-calorie diets. Evidence suggests that increasing intake plant protein could reduce risk type 2 diabetes. We sought for association between changes healthy diets without nor glucose-lowering medication, and diabetes coronary heart disease patients from CORDIOPREV study. Methods Newly diagnosed participants treatment were randomized consume Mediterranean low-fat...