A5002079911- Nutritional Studies and Diet
- Telomeres, Telomerase, and Senescence
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Nutrition and Health in Aging
- Health, Environment, Cognitive Aging
- Adipokines, Inflammation, and Metabolic Diseases
- Health and Lifestyle Studies
- Nutrition, Genetics, and Disease
- Regulation of Appetite and Obesity
- Cardiovascular Health and Risk Factors
- Eating Disorders and Behaviors
- Dietary Effects on Health
- Frailty in Older Adults
- Agriculture Sustainability and Environmental Impact
- Sleep and related disorders
- MicroRNA in disease regulation
- Vitamin D Research Studies
- Consumer Attitudes and Food Labeling
- Diet, Metabolism, and Disease
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Physical Activity and Health
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2024
Instituto de Salud Carlos III
2023-2024
University of Córdoba
2023-2024
Instituto Maimónides de Investigación Biomédica de Córdoba
2023-2024
Navarre Institute of Health Research
2017-2024
Centro de Investigación Biomédica en Red
2023-2024
Hospital Universitario Reina Sofía
2023-2024
Universidad de Navarra
2017-2024
University College Dublin
2019
High rates of childhood obesity require integral treatment with lifestyle modifications that achieve weight loss. We evaluated a intervention on nutrient adequacy and diet quality in children adolescents abdominal obesity. A randomized controlled trial was performed 107 participants, assigned either to usual care group or an intensive followed moderate hypocaloric Mediterranean received nutritional education. Intake using Dietary Reference Intakes through the Diet Quality Index for...
Abstract Background Telomere Length (TL), a marker of cellular aging, holds promise as biomarker to elucidate the molecular mechanism diabetes. This study aimed investigate whether shorter telomeres are associated with higher risk type 2 diabetes mellitus (T2DM) incidence in patients coronary heart disease; and determine most suitable dietary patterns, particularly Mediterranean diet or low-fat diet, can mitigate development these after follow-up period five years. Methods The CORonary Diet...
It is unclear how dietary, physical activity and sedentary behaviors co-occur in school-aged children. We investigated the clustering of energy balance-related whether identified clusters were associated with weight status. Participants 6- to 9-year-old children (n = 63,215, 49.9% girls) from 19 countries participating fourth round (2015/2017) World Health Organization (WHO) European Childhood Obesity Surveillance Initiative. Energy parentally reported. Weight height objectively measured....
Type 2 diabetes mellitus (T2DM) is recognized an independent risk factor for chronic kidney disease (CKD). The precise contribution and differential response to treatment strategies reduce dysfunction, depending on whether obesity present alongside T2DM or not, remain be fully clarified. Our objective was improve our understanding of how contributes function in patients with coronary heart (CHD), who are highly predisposed CKD, assign the most effective dietary approach preserve function.
Background Inflammation related molecules such as tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), and cardiotrophin-1 (CT-1) are highly expressed in obese individuals could partly explain some comorbidities associated to obesity. In children, lifestyle interventions able lower inflammation reduce cardiovascular risk factors with The aim of the present work was study changes inflammation-related serum peripheral blood mononuclear cells (PBMC) transcript levels after a 10-week...
Summary Background Recent studies have associated several microRNAs (miRNAs) with childhood obesity and energy homeostasis, suggesting that an individual miRNA profile could be used as early predictor to estimate the response weight loss interventions in design of precision nutrition. Objective To investigate associations between expression circulating adiposity‐related miRNAs a intervention. Methods A total 51 Spanish girls (age 7–16 years) abdominal underwent 8 weeks multidisciplinary...
In order to evaluate whether telomere maintenance is associated with type 2 diabetes remission, newly diagnosed patients without glucose-lowering treatment (183 out of 1002) from the CORDIOPREV study (NCT00924937) were randomized consume a Mediterranean or low-fat diet. Patients classified as Responders, those who reverted during 5 years dietary intervention (
This study tried to examine the association between frequency of family meals and excess weight using large representative samples children adolescents from 43 countries.
Background: Elevated circulating plasma levels of both lipopolysaccharide-binding protein (LBP) and chemerin are reported in patients with obesity, but few studies available on lifestyle intervention programs. We investigated the association LBP metabolic syndrome (MetS) outcomes a children adolescents abdominal obesity Methods: Twenty-nine enrolled randomized controlled trial were selected. The 2-month intensive phase subsequent 10-month follow-up consisted moderate calorie-restricted diet,...
Mutations leading to a reduced function of the melanocortin-4 receptor (MC4R) exert major gene effect on extreme obesity. Recently it was shown that bone derived hormone lipocalin 2 (LCN2) binds MC4R and activates dependent anorexigenic pathway. We identified mutations in both genes screened effects
Physical activity (PA) is associated with changes in body composition that affect insulin sensitivity and leptin levels. Few studies have assessed the effect of lifestyle interventions on objectively measured PA levels obese children. To evaluate effects a multidisciplinary intervention anthropometric indices, biochemical parameters accelerometer abdominal A randomized control trial was performed 106 children adolescents obesity. Participants were randomly assigned to usual or intensive care...
The purpose of this study was to assess the effect physical activity (PA) changes, measured by accelerometry, on telomere length (TL) in pediatric patients with abdominal obesity after a lifestyle intervention. One hundred and twenty-one children (7-16 years old) were randomized intervention (a moderately hypocaloric Mediterranean diet) or usual care group (standard recommendations) for 22 months 2 month intensive phase subsequent 20 follow-up). Both groups encouraged accumulate an extra 200...
Exposure to persistent organic pollutants (POPs) may influence telomere length (TL), which is considered as a marker of biological age associated with the risk chronic disease. We hypothesized that dietary exposure polychlorinated biphenyls (PCBs) and dioxins could affect TL. Our aim was evaluate association PCBs In this cross-sectional study 886 subjects older than 55 y (mean age: 67.7; standard deviation (SD): 6.1; 27% women) from "Seguimiento Universidad de Navarra" (SUN) project. TL...
Summary Background Dietary factors seem to influence telomere length. Moreover, associations between changes in adiposity indices and length (TL) have been found intervention studies. Objective We evaluated two diet quality their association with TL children abdominal obesity a 12‐month lifestyle intervention. Methods Eighty‐seven participants (7‐16 years old) were assigned the (moderate hypocaloric Mediterranean diet) or usual care group (standard paediatric recommendations) for 2‐month...
Telomeres are noncoding regions located at the end of chromosomes and their shortening has been associated with risk factors cardiovascular disease. The aim this study was to evaluate association between ideal health (Life's simple 7) odds having short telomeres in a subsample participants older than 55 years from Seguimiento Universidad de Navarra (SUN) study.We included 886 (645 men 241 women). Telomere length measured using real-time quantitative polymerase chain reaction. Cardiovascular...
serotonin signaling participates in body weight regulation and glucose metabolism. However, little information is available on circulating levels obese subjects after a loss program. We aimed to assess the effect of lifestyle intervention children possible associations with anthropometric blood measurements.forty-four were enrolled ten-week consisting moderate caloric restriction diet, nutritional education familial involvement. They distributed according response. Subjects who lost > 0.5...
childhood obesity and sleep disorders have a well-established cross-sectional association, but lifestyle interventions' effects on quality remain under-researched. This study aimed to evaluate the of 122 participants (7-16 years) with abdominal after 2-year necessary intervention.participants were assigned either intervention group (moderate hypocaloric Mediterranean Diet) or usual care (standard recommendations healthy diet). Sleep was objectively assessed using triaxial accelerometry,...
Abstract Telomere integrity is influenced by oxidative stress. Also, inflammation-related factors, including nutritional could modulate telomere integrity. The relationship between a posteriori -derived dietary patterns and length (TL) has been scarcely investigated. Thus, our objective was to examine the association empirically derived ascertained through principal component analysis (PCA) TL in an older adult Spanish population. A total of 886 adults (>55 years old; 645 males 241...