Carolina Donat‐Vargas

ORCID: 0000-0002-4523-4148
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About
Contact & Profiles
Research Areas
  • Nutritional Studies and Diet
  • Toxic Organic Pollutants Impact
  • Consumer Attitudes and Food Labeling
  • Per- and polyfluoroalkyl substances research
  • Nutrition and Health in Aging
  • Effects and risks of endocrine disrupting chemicals
  • Air Quality and Health Impacts
  • Obesity, Physical Activity, Diet
  • Social Media in Health Education
  • Fatty Acid Research and Health
  • Diet and metabolism studies
  • Water Treatment and Disinfection
  • Health, Environment, Cognitive Aging
  • Frailty in Older Adults
  • Health Literacy and Information Accessibility
  • Opioid Use Disorder Treatment
  • Sodium Intake and Health
  • Vitamin D Research Studies
  • Chemical Analysis and Environmental Impact
  • Birth, Development, and Health
  • Mental Health via Writing
  • Atmospheric chemistry and aerosols
  • HIV, Drug Use, Sexual Risk
  • Antioxidant Activity and Oxidative Stress
  • Climate Change and Health Impacts

Barcelona Institute for Global Health
2022-2025

Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2019-2025

Karolinska Institutet
2016-2025

Universidad Autónoma de Madrid
2019-2024

IMDEA Food
2019-2024

Consejo Superior de Investigaciones Científicas
2020-2024

Madrid Institute for Advanced Studies
2019-2024

Instituto de Salud Carlos III
2015-2023

Agència de Salut Pública de Catalunya
2023

Universitat Pompeu Fabra
2023

Breast cancer is the leading cause of female burden, and its incidence has increased by more than 20% worldwide since 2008. Some observational studies have suggested that Mediterranean diet may reduce risk breast cancer.To evaluate effect 2 interventions with vs advice to follow a low-fat (control) on incidence.The PREDIMED study 1:1:1 randomized, single-blind, controlled field trial conducted at primary health care centers in Spain. From 2003 2009, 4282 women aged 60 80 years high...

10.1001/jamainternmed.2015.4838 article EN JAMA Internal Medicine 2015-09-14

Perfluoroalkyl substances (PFAS) are persistent synthetic chemicals that may affect components of metabolic risk through the peroxisome proliferator-activated receptor but epidemiological data remain scarce and inconsistent. To estimate associations between repeated measurements main PFAS in plasma total cholesterol, triglycerides hypertension among control subjects from a population-based nested case-control study on diabetes type 2 middle-aged women men. Participants (n = 187) were free at...

10.1016/j.envint.2019.01.007 article EN cc-by-nc-nd Environment International 2019-01-10

Abstract Background Ultra-processed food intake has been associated with chronic conditions and mortality. The aim of this study was to assess the relationship between ultra-processed incident frailty in community-dwelling older adults. Methods Prospective cohort 1,822 individuals aged at least 60 years who were recruited during 2008–2010 Spain. At baseline, consumption obtained using a validated computerized face-to-face dietary history. foods identified according nature extent their...

10.1093/gerona/glz140 article EN The Journals of Gerontology Series A 2019-05-27

Introduction Cocaine abuse represents a major public health concern. The social perception of cocaine has been changing over the decades, phenomenon closely tied to its patterns use and abuse. Twitter is valuable tool understand status drug globally. However, no specific studies discussing have conducted on this platform. Methods 111,508 English Spanish tweets containing “cocaine” from 2018 2022 were analyzed. 550 manually studied, largest subset underwent automated classification. Then,...

10.3389/fpsyt.2024.1282026 article EN cc-by Frontiers in Psychiatry 2024-03-19

Perfluoroalkyl substances (PFAS) have drawn much attention due to bioaccumulation potential and their current omnipresence in human blood. We assessed whether plasma PFAS, suspected induce endocrine-disrupting effects, were prospectively associated with clinical type 2 diabetes (T2D) risk. established a nested case-control study within the Swedish prospective population-based Västerbotten Intervention Programme cohort. Several PFAS measured from subset of 124 pairs at baseline (during...

10.1016/j.envint.2018.12.026 article EN cc-by-nc-nd Environment International 2018-12-19

Introduction and objectives. Ultra-processed food (UPF) consumption has been associated with increased incidence of cardiovascular disease its risk factors. The aim this study was to assess, for the first time in literature, prospective association between UPF abdominal obesity (AO) older adults. Methods. sample consists 652 participants Seniors Study on Nutrition Cardiovascular Risk Spain: Seniors-ENRICA-1 study, (mean age 67, 44% women). At baseline, standardized anthropometric...

10.3390/nu12082368 article EN Nutrients 2020-08-07

Ultra-processed food (UPF) consumption has been associated with increased risk of cardiovascular factors and mortality. However, little is known on the UPF effect renal function. The aim this study to assess prospectively association between function decline. This a prospective cohort 1312 community-dwelling individuals aged 60 older recruited during 2008-2010 followed up December 2015. At baseline, validated dietary history was obtained. identified according NOVA classification. baseline at...

10.3390/nu13020428 article EN Nutrients 2021-01-28

Abstract Background Electroconvulsive therapy (ECT) is an effective and safe medical procedure that mainly indicated for depression, but also patients with other conditions. However, ECT among the most stigmatized controversial treatments in medicine. Our objective was to examine social media contents on Twitter related identify evaluate public views matter. Methods We collected posts English Spanish mentioning between January 1, 2019 October 31, 2020. Identified tweets were subject a mixed...

10.1192/j.eurpsy.2022.2359 article EN cc-by-nc-nd European Psychiatry 2023-01-01

Cardiovascular disease (CVD) development may be linked to persistent organic pollutants (POPs), including organochlorine compounds (OCs) and perfluoroalkyl polyfluoroalkyl substances (PFAS). To explore underlying mechanisms, we investigated metabolites, proteins, genes linking POPs with CVD risk. We used data from a nested case-control study on myocardial infarction (MI) stroke the Swedish Mammography Cohort – Clinical (n = 657 subjects). OCs, PFAS, multiomics (9511 liquid...

10.1021/acs.est.3c06388 article EN cc-by Environmental Science & Technology 2024-01-04

Abstract Background Ultra-processed food (UPF) consumption, which is increasing worldwide, has recently been associated with an increased risk of death and cardiovascular disease. We aimed to assess whether consumption UPF directly subclinical coronary atherosclerosis in middle-aged men. Methods A computed tomography scan was performed on 1876 men from the Aragon Workers’ Health Study, recruited January 2011 December 2014, calcium. All participants were free heart Dietary intake collected by...

10.1186/s12916-020-01678-8 article EN cc-by BMC Medicine 2020-08-13

Background & aimsThe specific association of olive oil consumption with coronary heart disease (CHD) or stroke has not been totally established.Objective: to examine whether is associated subclinical atherosclerosis, the risk total cardiovascular (CVD), CHD, and stroke.MethodsThree cohorts were included: AWHS (2318 men), SUN Project (18,266 men women), EPIC-Spain (39,393 women). Olive was measured at baseline using validated questionnaires.ResultsIn AWHS, 747 participants had a positive...

10.1016/j.clnu.2021.11.002 article EN cc-by-nc-nd Clinical Nutrition 2021-11-15

Cadmium (Cd) is a toxic metal, which the non-smoking population mainly exposed to through diet. Current health-based guidance values are based on renal toxicity; however, emerging evidence suggests that bone and cardiovascular system might be more sensitive Cd exposure. To assess association of urinary (U-Cd) with incidence fractures, myocardial infarction, heart failure, ischemic stroke mortality in postmenopausal women. We used data from 4024 women, aged 56–85 population-based prospective...

10.1016/j.envint.2022.107114 article EN cc-by Environment International 2022-02-01

Background: Per- and polyfluoroalkyl substances (PFAS) are widespread persistent pollutants that have been associated with elevated cholesterol levels. However, data on incident cardiovascular disease (CVD) is lacking. Objectives: We investigated the association of exposure to PFAS risk myocardial infarction stroke and, subsidiary, baseline blood lipids. Methods: This population-based nested case–control study included first cases matched controls from two Swedish cohorts: Mammography...

10.1289/ehp9791 article EN public-domain Environmental Health Perspectives 2022-03-01

Background: Nitrate and trihalomethanes (THMs) in drinking water are widespread potential human carcinogens. Objective: We evaluated the association between drinking-water exposure to nitrate THMs prostate cancer. Methods: During period 2008–2013, 697 hospital-based incident cancer cases (97 aggressive tumors) 927 population-based controls were recruited Spain, providing information on residential histories type of consumed. Average levels linked with lifetime consumption calculate...

10.1289/ehp11391 article EN public-domain Environmental Health Perspectives 2023-03-01

Teratogenic properties of perfluoroalkyl substances (PFAS) have been assessed in a few studies, however, epidemiological evidence for an association is inconclusive. We conducted Swedish nation-wide register-based cohort study to assess the associations estimated fetal exposure sum drinking water perfluorooctane sulfonic acid (PFOS), perfluorooctanoic (PFOA), perfluorononanoic (PFNA) and perfluorohexane (PFHxS) with major congenital malformations. included all births Sweden during 2012-2018...

10.1016/j.envint.2025.109381 article EN cc-by-nc-nd Environment International 2025-03-15

There is inconclusive evidence of associations between exposure to per- and polyfluoroalkyl substances (PFAS) diabetes hypertensive disorders during pregnancy. We conducted a nation-wide register-based cohort study assess the estimated maternal drinking water sum four major PFAS (PFAS4; perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), perfluorononanoate (PFNA) perfluorohexanoate (PFHxS)) with gestational mellitus (GDM), hypertension preeclampsia. included nulliparous women giving...

10.1016/j.envint.2025.109415 article EN cc-by Environment International 2025-03-28

Persistent organochlorine pollutants (POPs) have shown to be involved in the atherosclerotic process and cause endothelial cell dysfunction. To assess longitudinally whether plasma concentrations of different POPs were associated with blood pressure risk hypertension middle-aged women men. Study subjects 850 participants VIP (Västerbotten Intervention Programme) 2 samples measurements, 10 years apart, during 1990 2003 (baseline) 2000 2013 (follow-up). Dioxin-like nondioxin-like...

10.1161/hypertensionaha.117.10691 article EN cc-by-nc-nd Hypertension 2018-04-30

Perfluoroalkyl substances (PFAS) are widespread persistent environmental pollutants. There is evidence that PFAS induce metabolic perturbations in humans, but underlying mechanisms still unknown. In this exploratory study, we investigated PFAS-related plasma metabolites for their associations with type 2 diabetes (T2D) to gain potential mechanistic insight these perturbations. We used untargeted LC-MS metabolomics find related exposures a case-control study on T2D (n = 187 matched pairs)...

10.1016/j.envint.2020.106180 article EN cc-by Environment International 2020-10-25
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