A5037377852- Air Quality and Health Impacts
- Noise Effects and Management
- Water Treatment and Disinfection
- Toxic Organic Pollutants Impact
- Vehicle Noise and Vibration Control
- Fluoride Effects and Removal
- Monoclonal and Polyclonal Antibodies Research
- Magnesium in Health and Disease
- Environmental Chemistry and Analysis
- Heavy metals in environment
- Parathyroid Disorders and Treatments
- Health, Environment, Cognitive Aging
- Systemic Lupus Erythematosus Research
- Trace Elements in Health
- Potassium and Related Disorders
- Atmospheric chemistry and aerosols
- Wastewater Treatment and Reuse
- Hearing Loss and Rehabilitation
- Nutrition and Health in Aging
- Viral Infections and Immunology Research
- Effects and risks of endocrine disrupting chemicals
- Genetic Associations and Epidemiology
- Heavy Metal Exposure and Toxicity
- Bone health and osteoporosis research
- Environmental Justice and Health Disparities
Karolinska Institutet
2019-2025
Colorectal cancer is the third most common malignancy worldwide and strongly linked to lifestyle environmental risk factors. Although several drinking-water disinfection by-products are confirmed rodent carcinogens, evidence in humans for carcinogenicity associated with these by-products, including colorectal cancer, still inconclusive.
Chlorination by-products have been consistently associated with risk of bladder cancer in case-control studies, but confirmation from large-scale cohort studies is lacking. We assessed the association drinking water trihalomethanes (THM), a proxy for chlorination by-products, 58,672 men and women. Data came two population-based cohorts, parts Swedish Infrastructure Medical Population-Based Life-Course Environmental Research (SIMPLER). Individual exposure to THM was by combining residential...
Cadmium (Cd) is a toxic metal, which the non-smoking population mainly exposed to through diet. Current health-based guidance values are based on renal toxicity; however, emerging evidence suggests that bone and cardiovascular system might be more sensitive Cd exposure. To assess association of urinary (U-Cd) with incidence fractures, myocardial infarction, heart failure, ischemic stroke mortality in postmenopausal women. We used data from 4024 women, aged 56–85 population-based prospective...
Teratogenic properties of perfluoroalkyl substances (PFAS) have been assessed in a few studies, however, epidemiological evidence for an association is inconclusive. We conducted Swedish nation-wide register-based cohort study to assess the associations estimated fetal exposure sum drinking water perfluorooctane sulfonic acid (PFOS), perfluorooctanoic (PFOA), perfluorononanoic (PFNA) and perfluorohexane (PFHxS) with major congenital malformations. included all births Sweden during 2012-2018...
There is inconclusive evidence of associations between exposure to per- and polyfluoroalkyl substances (PFAS) diabetes hypertensive disorders during pregnancy. We conducted a nation-wide register-based cohort study assess the estimated maternal drinking water sum four major PFAS (PFAS4; perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), perfluorononanoate (PFNA) perfluorohexanoate (PFHxS)) with gestational mellitus (GDM), hypertension preeclampsia. included nulliparous women giving...
The implication of calcium and magnesium in drinking water for cardiovascular disease is unclear.To assess the association concentration with incidence myocardial infarction stroke, accounting dietary mineral intake.We linked monitoring data to residential information 26,733 women from population-based Swedish Mammography Cohort, who completed a 96-item FFQ at baseline. Drinking was categorized into low (magnesium <10 mg/L <50 mg/L) or high ≥10 ≥50 concentration. Incident cases stroke types...
BACKGROUND: Although randomized controlled trials (RCTs) have demonstrated that high fluoride increases bone mineral density (BMD) and skeletal fragility, observational studies of low-dose chronic exposure through drinking water (<1:5 mg=L, the maximum recommended by World Health Organization) been inconclusive.OBJECTIVE: We assessed associations in urine, intake via diet water, with BMD fracture incidence postmenopausal women exposed to ≤1 mg=L.METHODS: Data were from participants Swedish...
Environmental noise is an important environmental exposure that can affect health. An association between transportation and breast cancer incidence has been suggested, although current evidence limited. We investigated the pooled long-term to incidence.Pooled data from eight Nordic cohorts provided a study population of 111,492 women. Road, railway, aircraft were modelled at residential addresses. Breast (all, estrogen receptor (ER) positive, ER negative) was derived registries. Hazard...
Human biomonitoring (HBM) data in Europe are often fragmented and collected different EU countries sampling periods. Exposure levels for children adult women were evaluated over time. For the period 2000–2010, literature aggregated a harmonized way across studies. Between 2011–2012, biobanked samples from DEMOCOPHES project used. 2014–2021, HBM generated within HBM4EU Aligned Studies. Time patterns on internal exposure visually statistically using 50th 90th percentiles (P50/P90)...
There is inconclusive evidence for an association between per- and polyfluoroalkyl substances (PFAS) fetal growth. We conducted a nation-wide register-based cohort study to assess the associations of estimated maternal exposure sum (PFAS4) perfluorooctane sulfonic acid (PFOS), perfluorooctanoic (PFOA), perfluorononanoic (PFNA) perfluorohexane (PFHxS) with birthweight as well risk small- (SGA) large-for-gestational-age (LGA). included all births in Sweden during 2012–2018 mothers residing ≥...
Evidence from observational studies suggests that increased exposure to calcium may increase the risk of coronary heart disease and stroke whereas magnesium might have a protective effect on risk. However, associations these minerals with failure are scarce limited by potential biases introduced confounding reverse causality. We applied two-sample Mendelian randomization design using summary estimates assess whether serum concentrations causally associated failure. Summary statistics data...
Antibodies against phosphorylcholine (anti-PC) have been reported as associated with protection atherosclerosis, cardiovascular disease (CVD), and other chronic inflammatory diseases. Underlying potential mechanisms demonstrated include anti-inflammatory, clearance of dead cells, inhibition oxidized low-density lipoprotein effects.
Emerging evidence shows that long-term exposure to air pollution, road traffic noise, and greenness can each be associated with cardiovascular disease, but only few studies combined these exposures. In this study, we assessed associations of multiple environmental exposures incidence myocardial infarction using annual time-varying predictors.
Background: Available evidence suggests a link between exposure to transportation noise and an increased risk of obesity. We aimed assess exposure-response functions for long-term residential road traffic, railway aircraft noise, markers Methods: Our cross-sectional study is based on pooled data from 11 Nordic cohorts, including up 162,639 individuals with either measured (69.2%) or self-reported obesity data. Residential was estimated as time-weighted average L den 5 years before...
Abstract Background and aims Antibodies against phosphorylcholine (anti-PC) have been reported as associated with protection atherosclerosis, cardiovascular disease (CVD) other chronic inflammatory diseases. Underlying potential mechanisms demonstrated include anti-inflammatory, clearance of dead cells inhibition oxidized low-density lipoprotein-effects. The aim is to study the role IgM anti-PC incident CVD among women, where less known than men in general population. Methods In a total 932...
Background: Colon cancer incidence is rising globally, and factors pertaining to urbanization have been proposed involved in this development. Traffic noise may increase colon risk by causing sleep disturbance stress, thereby inducing known risk-factors, e.g. obesity, diabetes, physical inactivity, alcohol consumption, but few studies examined this.Objectives: The objective of study was investigate the association between traffic (all, proximal, distal) a pooled population 11 Nordic cohorts,...
Background: Randomized controlled trials have shown that high fluoride doses increases both bone mineral density and skeletal fragility. The consequences of long-term low dose exposure to fluoride, primarily via drinking water, on health among the general public is however not clear. In present study, we assessed associations in urine or beverages diet with postmenopausal women. Methods: We used population-based prospective Swedish Mammography Cohort- Clinical, encompassing 4306 women (aged...
BACKGROUND AND AIM: Exposure to chlorination by-products has been consistently associated with an increased risk of bladder cancer in case-control studies, but confirmation from large-scale cohort studies are lacking. We assessed the association drinking water trihalomethanes (THM), a surrogate for by-products, 58,672 men and women two population-based cohorts. METHODS: used data, including questionnaire information, Swedish Infrastructure Medical Population-Based Life-Course Environmental...