Argelia Castaño
A5011088512- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Carcinogens and Genotoxicity Assessment
- Heavy Metal Exposure and Toxicity
- Health, Environment, Cognitive Aging
- Air Quality and Health Impacts
- Environmental Toxicology and Ecotoxicology
- Mercury impact and mitigation studies
- Animal testing and alternatives
- Per- and polyfluoroalkyl substances research
- Inflammatory Bowel Disease
- Heavy metals in environment
- Eosinophilic Esophagitis
- Microplastics and Plastic Pollution
- Analytical chemistry methods development
- Pharmaceutical and Antibiotic Environmental Impacts
- Microscopic Colitis
- Ethics in Clinical Research
- Health Systems, Economic Evaluations, Quality of Life
- Molecular Biology Techniques and Applications
- Pesticide and Herbicide Environmental Studies
- Climate Change and Health Impacts
- Pesticide Residue Analysis and Safety
- Nutritional Studies and Diet
- Nanoparticles: synthesis and applications
Centro Nacional de Sanidad Ambiental
2015-2024
Instituto de Salud Carlos III
2015-2024
Central University Hospital of Asturias
2017-2024
University of Southern Denmark
2022-2023
Hrvatski zavod za javno zdravstvo
2023
Centro Nacional de Microbiologia
2010-2022
Flemish Institute for Technological Research
2012-2022
Instituto de Investigación Sanitaria del Principado de Asturias
2021
European Society for Blood and Marrow Transplantation
2020
Escuela Nacional de Sanidad
2009-2019
For Europe as a whole, data on internal exposure to environmental chemicals do not yet exist. Characterization of the individual chemical environment is expected enhance understanding threats health.We developed and applied harmonized protocol collect comparable human biomonitoring all over Europe.In 17 European countries, we measured mercury in hair cotinine, phthalate metabolites, cadmium urine 1,844 children (5-11 years age) their mothers. Specimens were collected 5-month period...
Due to global mercury pollution and the adverse health effects of prenatal exposure methylmercury (MeHg), an assessment economic benefits prevented developmental neurotoxicity is necessary for any cost-benefit analysis.Distributions hair-Hg concentrations among women reproductive age were obtained from DEMOCOPHES project (1,875 subjects in 17 countries) literature data (6,820 8 countries). The exposures assumed comply with log-normal distributions. Neurotoxicity estimated a linear...
The toxicity of methylmercury (MeHg) in humans is well established and the main source exposure via consumption large marine fish mammals. Of particular concern are potential neurodevelopmental effects early life to low-levels MeHg. Therefore, it important that pregnant women, children women childbearing age are, as far possible, protected from MeHg exposure. Within European project DEMOCOPHES, we have analyzed mercury (Hg) hair 1799 mother-child pairs 17 countries using a strictly...
The major purpose of human biomonitoring is the mapping and assessment exposure to chemicals. European initiative HBM4EU has prioritized seven substance groups two metals relevant for exposure: Phthalates substitutes (1,2-cyclohexane dicarboxylic acid diisononyl ester, DINCH), bisphenols, per- polyfluoroalkyl substances (PFASs), halogenated organophosphorous flame retardants (HFRs OPFRs), polycyclic aromatic hydrocarbons (PAHs), arylamines, cadmium chromium. As a first step towards...
A fundamental objective of the human biomonitoring for Europe initiative (HBM4EU) is to progress toward comparable and robust exposure data a wide variety prioritized chemicals in samples. programme Quality Assurance/Quality Control (QA/QC) was designed HBM4EU with purpose creating network European laboratories providing analytical high quality. Two approaches were chosen two sets different timelines: (i) Scheme 1, where interested candidate participated multiple rounds proficiency tests...
As part of the Human Biomonitoring for Europe (HBM4EU) initiative a human biomonitoring (HBM) survey is conducted in 21 countries. This builds on existing HBM capacity by aligning national or regional studies. The targets 3 age groups (i) children aged 6-11 years, (ii) teenagers 12-19 years and (iii) young adults 20-39 includes total 9493 participants (3151 children, 2953 3389 adults). Depending group, internal exposure to phthalates substitute Hexamoll® DINCH, brominated organophosphorus...
Although the exposure assessment of chemicals emerging concern (CECs) has taken a decisive step forward through advances in (bio)informatics, statistics, and development highly sophisticated analytical instruments, lack standardisation harmonisation workflows method performance for suspect non-target screening hampers interpretation results, their comparability thus, its transmission to policymakers. To date, unlike other research fields such as forensics or food analysis, there is...
Human biomonitoring has become a pivotal tool for supporting chemicals’ policies. It provides information on real-life human exposures and is increasingly used to prioritize chemicals of health concern evaluate the success chemical Europe launched ambitious REACH program in 2007 improve protection environment. In October 2020 EU commission published its new strategy sustainability towards toxic-free The European Parliament called upon collect data support chemical’s risk assessment...
The metal cadmium (Cd) is a widespread environmental pollutant with documented adverse effects on the kidneys and bones from long-term exposure, but insufficiently elucidated public health consequences such as risk of cardiovascular disease, hormone-related cancer in adults developmental children. This study first pan-European human biomonitoring project that succeeded performing harmonized measurements Cd urine comparable way mother-child couples 16 European countries. aim was to evaluate...
The EU human biomonitoring initiative, HBM4EU, aims to co-ordinate and advance (HBM) across Europe. Within its remit, the project is gathering new, policy relevant, EU-wide data on occupational exposure relevant priority chemicals developing new approaches for biomonitoring. In this manuscript, hexavalent chromium [Cr(VI)] study design presented as first example of HBM4EU approach. This involves eight European countries plans recruit 400 workers performing Cr(VI) surface treatment e.g....
Exposure to hexavalent chromium [Cr(VI)] may occur in several occupational activities, e.g., welding, Cr(VI) electroplating and other surface treatment processes. The aim of this study was provide EU relevant data on exposure support the regulatory risk assessment decision-making. In addition, capability validity different biomarkers for were evaluated. involved nine European countries 399 workers industry sectors with exposures such as bath plating, applying or removing paint tasks. We also...
One of the aims European Human Biomonitoring Initiative, HBM4EU, was to provide examples and good practices for effective use human biomonitoring (HBM) data in health risk assessment (RA). The need such information is pressing, as previous research has indicated that regulatory assessors generally lack knowledge experience HBM RA. By recognising this gap expertise, well added value incorporating into RA, paper support integration Based on work we different approaches including RA estimations...