Konstantinos C. Makris

ORCID: 0000-0001-5251-8619
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About
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Research Areas
  • Health, Environment, Cognitive Aging
  • Arsenic contamination and mitigation
  • Air Quality and Health Impacts
  • Nutritional Studies and Diet
  • Water Treatment and Disinfection
  • Climate Change and Health Impacts
  • Heavy metals in environment
  • Effects and risks of endocrine disrupting chemicals
  • Toxic Organic Pollutants Impact
  • Heavy Metal Exposure and Toxicity
  • Soil and Water Nutrient Dynamics
  • Pesticide Exposure and Toxicity
  • Global Public Health Policies and Epidemiology
  • Groundwater and Isotope Geochemistry
  • Environmental remediation with nanomaterials
  • Phosphorus and nutrient management
  • Thermoregulation and physiological responses
  • Carcinogens and Genotoxicity Assessment
  • Circadian rhythm and melatonin
  • Chronic Disease Management Strategies
  • Pharmaceutical and Antibiotic Environmental Impacts
  • Wastewater Treatment and Nitrogen Removal
  • Air Quality Monitoring and Forecasting
  • Mine drainage and remediation techniques
  • Indoor Air Quality and Microbial Exposure

Cyprus University of Technology
2015-2024

General Hospital of Attica
2023-2024

University of Washington
2023

Institute for Health Metrics and Evaluation
2023

Istituto Universitario di Studi Superiori di Pavia
2023

European Food Safety Authority
2023

Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail
2023

Wageningen University & Research
2023

Barcelona Institute for Global Health
2023

Universidade Nova de Lisboa
2023

Hexavalent chromium is a known carcinogen when inhaled, but its carcinogenic potential orally ingested remains controversial. Water contaminated with hexavalent worldwide problem, making this question of significant public health importance. We conducted an ecological mortality study within the Oinofita region Greece, where water has been chromium. calculated gender, age, and period standardized ratios (SMRs) for all deaths, cancer specific types residents over 11-year (1999 - 2009), using...

10.1186/1476-069x-10-50 article EN cc-by Environmental Health 2011-05-24

Background: Trihalomethanes (THMs) are widespread disinfection by-products (DBPs) in drinking water, and long-term exposure has been consistently associated with increased bladder cancer risk. Objective: We assessed THM levels water the European Union as a marker of DBP estimated attributable burden cancer. Methods: collected recent annual mean municipal 28 countries (EU28) from routine monitoring records. linear exposure–response function for average residential by pooling data studies...

10.1289/ehp4495 article EN public-domain Environmental Health Perspectives 2020-01-01

Abstract This paper explores the exposome concept and its role in elucidating interplay between environmental exposures human health. We introduce two key concepts critical for exposomics research. Firstly, we discuss joint impact of genetics environment on phenotypes, emphasizing variance attributable to shared non-shared factors, underscoring complexity quantifying exposome's influence health outcomes. Secondly, importance advanced data-driven methods large cohort studies exposomic...

10.1093/exposome/osae001 article EN cc-by-nc Exposome 2024-01-17

Safety and security are two important features of urban drinking-water distribution systems (UDWDS), worldwide, that often compromised by a suite physical, hydraulic, chemical factors adversely impacting quality potable water reaching consumer taps. Growth scales biofilm conglomerates (SBC) coupled with sorption chemicals planktonic microorganisms SBC has been increasingly recognized as underestimated contaminant sources in aging pipe networks UDWDS. The main objective this study was to...

10.1080/10643389.2013.790746 article EN Critical Reviews in Environmental Science and Technology 2013-09-06

Background: Knowledge about the population's iodine status is important, because it allows adjustment of supply and prevention deficiency. The validity comparability iodine-related population studies can be improved by standardization, which was one goals EUthyroid project. aim this study to establish first standardized map in Europe using urinary concentration (UIC) data. Materials Methods: We established a gold-standard laboratory Helsinki measuring UIC inductively coupled plasma mass...

10.1089/thy.2019.0353 article EN Thyroid 2020-05-28

Human biomonitoring has become a pivotal tool for supporting chemicals’ policies. It provides information on real-life human exposures and is increasingly used to prioritize chemicals of health concern evaluate the success chemical Europe launched ambitious REACH program in 2007 improve protection environment. In October 2020 EU commission published its new strategy sustainability towards toxic-free The European Parliament called upon collect data support chemical’s risk assessment...

10.3390/ijerph19116787 article EN International Journal of Environmental Research and Public Health 2022-06-01

Drinking-water treatment residuals (WTRs) can immobilize excess soil phosphorus (P), but little is known about the long-term P retention by WTRs. To evaluate sorption characteristics of one Fe- and Al-based WTR, physicochemical properties pertinent to time-dependency hysteresis were assessed. This study also investigated mechanisms that could affect stability sorbed Phosphorus kinetics WTRs exhibited a slow phase followed an initial rapid phase, as typically occurs with metal hydroxides....

10.1021/es049161j article EN Environmental Science & Technology 2004-11-13

Drinking-water treatment residuals (WTRs) are nonhazardous materials that can be obtained free-of-charge from drinking-water plants to reduce soluble phosphorus (P) concentrations in poorly P sorbing soils. Phosphorus sorption capacities of WTRs vary 1−2 orders magnitude, on the basis short-term equilibration times (up 7 d), but studies dealing with long-term (weeks months) retention by lacking. Properties most affect pertinent efficacy as amendments stabilize This research addressed 80 d)...

10.1021/es0480769 article EN Environmental Science & Technology 2005-05-04

Although the increasing prevalence of thyroid nodular disease (TND) has been partially attributed to more frequent usage improved diagnostics, environmental factors, such as exposures thyroid-disrupting chemicals may contribute TND and altered function. We investigated association between bisphenol A (BPA), its chlorinated derivatives (ClxBPA), F (BPF) with measures in adult women. case-control study Cyprus Romania (n = 212) was conducted, where cases were those nodules (diameter >3mm),...

10.1371/journal.pone.0155237 article EN cc-by PLoS ONE 2016-10-26

Non-persistent endocrine disrupting chemicals (npEDCs) can affect multiple organs and systems in the body. Whether npEDCs accumulate human brain is largely unknown. The major aim of this pilot study was to examine presence environmental phenols parabens two distinct regions: hypothalamus white-matter tissue. In addition, a potential association between these concentrations obesity investigated. Post-mortem material obtained from 24 individuals, made up 12 obese normal-weight subjects...

10.3390/ijerph14091059 article EN International Journal of Environmental Research and Public Health 2017-09-13

Exposure to various pesticides, such as pyrethroids and chlorpyrifos, has been previously associated with adverse effects on children's health. Scientific evidence the human toxicity of glyphosate (GLY) its primary metabolite, aminomethylphosphonic acid (AMPA) is limited, particularly for children. This study aimed i) assess exposure determinants studied pesticides measured in children Cyprus, ii) determine association between urinary biomarkers DNA lipid oxidative damage.A health was set up...

10.1016/j.envres.2022.113316 article EN cc-by Environmental Research 2022-04-16

Swine diets are often supplemented by organoarsenicals, such as 3-nitro-4-hydroxyphenylarsonic acid (roxarsone) to treat animal diseases and promote growth. Recent work reported roxarsone degradation under anaerobic conditions in poultry litter, but no data exist for swine wastes typically stored lagoons nearby concentrated feeding operations (CAFOs). The objectives of this study were to: (i) characterize a suite collected from 19 randomly selected CAFOs soluble arsenate [As(V)], arsenite...

10.2134/jeq2007.0479 article EN Journal of Environmental Quality 2008-06-24

ABSTRACT Excessive soluble P in runoff is a common cause of eutrophication fresh waters. Evidence indicates that drinking water treatment residuals (WTRs) can reduce concentrations P‐impacted soils the short term (days to weeks). The long‐term (years) stability WTR‐immobilized has been inferred, but validating field data are scarce. This research was undertaken at two Michigan sites with history heavy manure applications study longevity alum‐based WTR (Al‐WTR) effects on solubility over time...

10.2134/jeq2006.0162 article EN Journal of Environmental Quality 2007-01-01

With the exception of polycarbonate (PC) baby bottles, little attention has been paid to bisphenol A (BPA) intake from packaged water consumption (PC dispensers), especially during summer weather conditions. We determined magnitude and variability urinary BPA concentrations in 35 healthy individuals largely relying upon PC satisfy their potable needs. used liquid chromatography-tandem mass spectrometry measure concentrations. questionnaire was administered July/August a spot urine sample...

10.1021/es304038k article EN Environmental Science & Technology 2013-02-28

Evidence of bisphenols' obesogenic effects on humans is mixed and inconsistent. We aimed to explore the presence bisphenol A (BPA), F (BPF) chlorinated BPA (ClBPA), collectively called bisphenols, in different brain regions their association with obesity using post-mortem hypothalamic white matter material from twelve pairs obese (body mass index (BMI) >30 kg/m2) normal-weight individuals (BMI <25 kg/m2). Mean ratios hypothalamus:white for BPA, BPF ClBPA were 1.5, 0.92, 0.95, respectively,...

10.1038/s41598-018-26498-y article EN cc-by Scientific Reports 2018-05-22

Human biomonitoring (HBM) data measured in specific contexts or populations provide information for comparing population exposures. There are numerous health-based guidance values, but to locate these interested parties need seek them out individually from publications, governmental reports, websites and other sources. Until now, there has been no central, international repository this information. Thus, a tool is needed help researchers, public health professionals, risk assessors,...

10.1016/j.ijheh.2022.114046 article EN cc-by International Journal of Hygiene and Environmental Health 2022-11-07
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