Loïc Rambaud
A5021477091- Effects and risks of endocrine disrupting chemicals
- Health, Environment, Cognitive Aging
- Toxic Organic Pollutants Impact
- Air Quality and Health Impacts
- Per- and polyfluoroalkyl substances research
- Potato Plant Research
- Carcinogens and Genotoxicity Assessment
- Pain Management and Treatment
- Pesticide Exposure and Toxicity
- Pesticide and Herbicide Environmental Studies
- Health Systems, Economic Evaluations, Quality of Life
- Heavy Metal Exposure and Toxicity
- Weed Control and Herbicide Applications
- Heavy metals in environment
- Food Safety and Hygiene
- Myofascial pain diagnosis and treatment
- Transcranial Magnetic Stimulation Studies
- Data-Driven Disease Surveillance
- Health and Medical Research Impacts
- Pharmaceutical studies and practices
- Research Data Management Practices
- Pain Mechanisms and Treatments
- Gestational Diabetes Research and Management
- Animal testing and alternatives
- Garlic and Onion Studies
Santé Publique France
2017-2025
Institut thématique Santé Publique
2017-2025
University of Southern Denmark
2022-2023
German Environment Agency
2022
Swiss Tropical and Public Health Institute
2022
Institut de Veille Sanitaire
2010-2017
Centre Hospitalier Saint-Joseph Saint-Luc
2012
Ostreopsis ovata and siamensis are tropical unicellular algae that have been found recently in the Mediterranean. Both of these dinoflagellates produce palytoxin (PTX)-like toxins powerful vasoconstrictors mammals. Since 2003, blooms Italy Spain accompanied by reports respiratory problems skin/mucosa irritation persons contact with toxic microalgal cells (epiphytes, plankton, or sea spray) associated toxins.In France, a surveillance network has set up to monitor water conditions protect...
The major purpose of human biomonitoring is the mapping and assessment exposure to chemicals. European initiative HBM4EU has prioritized seven substance groups two metals relevant for exposure: Phthalates substitutes (1,2-cyclohexane dicarboxylic acid diisononyl ester, DINCH), bisphenols, per- polyfluoroalkyl substances (PFASs), halogenated organophosphorous flame retardants (HFRs OPFRs), polycyclic aromatic hydrocarbons (PAHs), arylamines, cadmium chromium. As a first step towards...
As part of the Human Biomonitoring for Europe (HBM4EU) initiative a human biomonitoring (HBM) survey is conducted in 21 countries. This builds on existing HBM capacity by aligning national or regional studies. The targets 3 age groups (i) children aged 6-11 years, (ii) teenagers 12-19 years and (iii) young adults 20-39 includes total 9493 participants (3151 children, 2953 3389 adults). Depending group, internal exposure to phthalates substitute Hexamoll® DINCH, brominated organophosphorus...
As part of the French Human Biomonitoring (HBM) programme, Esteban study described, among other things, biomarkers levels various chemicals in adults (18-74 years old) and children (6-17 old). This paper describes design provides, for first time, data on biological exposure general population to a wide range contaminants posing threat human health which are currently found domestic environments.Esteban is cross-sectional conducted nationwide sample population. Exposure six families deemed...
Human biomonitoring has become a pivotal tool for supporting chemicals’ policies. It provides information on real-life human exposures and is increasingly used to prioritize chemicals of health concern evaluate the success chemical Europe launched ambitious REACH program in 2007 improve protection environment. In October 2020 EU commission published its new strategy sustainability towards toxic-free The European Parliament called upon collect data support chemical’s risk assessment...
Per- and polyfluoroalkyl substances (PFASs) are a highly persistent, mobile, bioaccumulative class of chemicals, which emissions into the environment result in long-lasting contamination with high probability for causing adverse effects to human health environment. Within European Biomonitoring Initiative HBM4EU, samples data were collected harmonized way from biomonitoring (HBM) studies Europe derive current exposure across geographic spread. We performed mixture risk assessments based on...
Human biomonitoring (HBM) data measured in specific contexts or populations provide information for comparing population exposures. There are numerous health-based guidance values, but to locate these interested parties need seek them out individually from publications, governmental reports, websites and other sources. Until now, there has been no central, international repository this information. Thus, a tool is needed help researchers, public health professionals, risk assessors,...
Few data are available on the exposure of children to glyphosate (Gly) in Europe. Within HBM4EU, new HBM were collected from aligned studies at five sampling sites distributed over Europe (studies: SLO CRP (SI); ORGANIKO (CY); GerES V-sub (DE); 3XG (BE); ESTEBAN (FR)). Median Gly concentrations urine below or around detection limit (0.1 µg/L). The 95th percentiles ranged between 0.18 and 1.03 µg Gly/L. ratio AMPA (aminomethylphosphonic acid; main metabolite Gly) molar basis was average 2.2...
Pyrethroids are a major insecticide class, suitable for biomonitoring in humans. Due to similarities structure and metabolic pathways, urinary metabolites common various active substances. A tiered approach is proposed risk assessment. Tier I was conservative screening overall pyrethroid exposure, based on phenoxybenzoic acid metabolites. Subsequently, probabilistic approaches more specific were used refining the estimates. Exposure 95th percentiles from HBM4EU aligned studies (2014-2021)...
Human biomonitoring (HBM) data in Europe are often fragmented and collected different EU countries sampling periods. Exposure levels for children adult women were evaluated over time. For the period 2000–2010, literature aggregated a harmonized way across studies. Between 2011–2012, biobanked samples from DEMOCOPHES project used. 2014–2021, HBM generated within HBM4EU Aligned Studies. Time patterns on internal exposure visually statistically using 50th 90th percentiles (P50/P90)...
Within HBM4EU, human biomonitoring (HBM) studies measuring glyphosate (Gly) and aminomethylphosphonic acid (AMPA) in urine samples from the general adult population were aligned quality-controlled/assured. Data four (ESB Germany (2015-2020); Swiss HBM4EU study (2020); DIET-HBM Iceland (2019-2020); ESTEBAN France (2014-2016)) included representing Northern Western Europe. Overall, median values below reported quantification limits (LOQs) (0.05-0.1 µg/L). The 95th percentiles (P95) ranged...
Bisphenol A (BPA; or 4,4'-isopropylidenediphenol) is an endocrine disrupting chemical. It was widely used in a variety of plastic-based manufactured products for several years. The European Food Safety Authority (EFSA) recently reduced the Tolerable Daily Intake (TDI) BPA by 20,000 times due to concerns about immune-toxicity.
Due to their extensive usage, organophosphorus flame retardants (OPFRs) have been detected in humans and the environment. Human are exposed OPFRs via inhalation of indoor air, dust uptake or dietary through contaminated food drinking water. Only recently, few studies addressing exposure were published. In this study, we used human biomonitoring (HBM) data estimate how much intake may contribute total exposure. We estimated by reverse dosimetry, daily tris (2-chloroethyl) phosphate (TCEP),...