A5023435459- Poisoning and overdose treatments
- Venomous Animal Envenomation and Studies
- Marine Toxins and Detection Methods
- Rabies epidemiology and control
- Marine Invertebrate Physiology and Ecology
- Plant Toxicity and Pharmacological Properties
- Insect and Pesticide Research
- Healthcare and Venom Research
- Forensic Toxicology and Drug Analysis
- Drug-Induced Hepatotoxicity and Protection
- Silymarin and Mushroom Poisoning
- Plant-based Medicinal Research
- Entomological Studies and Ecology
- Pesticide Exposure and Toxicity
- Cassava research and cyanide
- Pharmacological Effects and Toxicity Studies
- Alcoholism and Thiamine Deficiency
- Animal Ecology and Behavior Studies
- African Botany and Ecology Studies
- Epilepsy research and treatment
- Yersinia bacterium, plague, ectoparasites research
- Beetle Biology and Toxicology Studies
- Nicotinic Acetylcholine Receptors Study
- Marine Ecology and Invasive Species
- Complementary and Alternative Medicine Studies
Hôpital Sainte-Marguerite
2015-2024
Centre Norbert Elias
2013-2024
Assistance Publique Hôpitaux de Marseille
2014-2023
Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail
2022
Agence Nationale des Fréquences
2022
Hôpital de la Timone
2021
Délégation Provence et Corse
2016-2018
Community Research and Development Information Service
2018
Institut de Veille Sanitaire
2017
Agence Nationale de Sécurité du Médicament et des Produits de Santé
2012-2017
Ostreopsis ovata and siamensis are tropical unicellular algae that have been found recently in the Mediterranean. Both of these dinoflagellates produce palytoxin (PTX)-like toxins powerful vasoconstrictors mammals. Since 2003, blooms Italy Spain accompanied by reports respiratory problems skin/mucosa irritation persons contact with toxic microalgal cells (epiphytes, plankton, or sea spray) associated toxins.In France, a surveillance network has set up to monitor water conditions protect...
The variation of venom composition with geography is an important aspect intraspecific variability in the Vipera genus, although causes this remain unclear. diversity snake both for our understanding venomous evolution and preparation relevant antivenoms to treat envenomations. A geographic was recently reported aspis France. Since 1992, cases human envenomation after bites south-east France involving unexpected neurological signs were regularly reported. presence genes encoding PLA(2)...
Introduction. The presence of exotic, and sometimes venomous, pets in European homes is becoming more common. This phenomenon the basis a French-German cooperative evaluation species causing injuries circumstances, severity, treatment envenomations Methods. A retrospective, descriptive, cross-sectional, case series data from 1996 to 2006. study sample consists all cases bites stings by exotic that were registered at four poisons centers. inclusion criteria human beings. Results. From 2006...
A retrospective case review study of viper envenomations collected by the Marseille's Poison Centre between 1996 and 2008 was performed.174 cases were studied (52 grade 1 = G1, 90 G2 32 G3). G1 patients received symptomatic treatments (average hospital stay 0.96 day). One hundred six (106) G2/G3 treated with antivenom Viperfav* (2.1+/-0.9 days in hospital), while 15 them only (plus one immediate death) (8.1+/-4 hospital, 2 died). The significantly reduced group (p < 0.001), none 106 had...
Shiitake (Lentinula edodes) is an edible mushroom which was initially grown in Japan and China now sold on the European market. Flagellate erythema may arise following shiitake consumption first described 1974.This paper reports a French dermatitis case series.The findings of retrospective study cases, reported to Poison Control Centres (PCC) from January 2000 December 2013, are reported.Among 32 exposed patients, 15 presented flagellate urticarial lesions after raw consumption. The this...
Background: Alcohol use disorders are frequently associated with self-intoxication in attempted suicide. In France since 2008, the off-label of baclofen for treatment alcohol dependence has greatly increased, leading to temporary regulation drug. At request national authorities, French Poison Control Centers carried out a retrospective survey give an overview exposure this population.Methods: A study was from January 2008 December 2013, focusing on exposures alcohol-dependent patients...
This paper summarizes the research conducted by partners of EU co-funded CoCliME project to ascertain ecological, human health and economic impacts Ostreopsis (mainly O. cf. ovata) blooms in NW Mediterranean coasts France, Monaco Spain. knowledge is necessary design strategies prevent, mitigate and, if necessary, adapt these events future other regions. proliferations have been related massive mortalities benthic organisms symptoms respiratory cutaneous irritation humans. A six-year...
Background. Ciguatera is a disease caused by the ingestion of fish containing toxins Gambierdiscus toxicus. This dinoflagellate frequently found in damaged coral reef systems. Previously rare Europe, this entity now seen tourists returning from tropical countries. Case series. Eighteen patients were examined between 1997 and 2002. Nine poisonings occurred Atlantic Ocean islands, eight Pacific one Egyptian Red Sea coast. Gastrointestinal signs always present areas, but less severe or absent...
The Portuguese man-o-war is a cnidaria classically found in tropical waters. It can cause serious and even life-threatening envenomation swimmers, surfers seafarers. Presence of the Atlantic species Physalia physalis has long been reported European coastal waters but was always an exceptional event.To describe experience Bordeaux Poison centre about stings since first collective episode 2008.Clinical retrospective description cases series envenomations to local poison from 2008 2011...
From January 2011 to March 2018, 26 patients aged from 20 80 years old reported being sick in France after eating sea figs of the genus Microcosmus. The had symptoms evoking a cerebellar syndrome: blurred or double vision, ataxia and dizziness, asthenia, headache, muscle cramps, paresthesia digestive disorders (nausea, vomiting diarrhea). Three 18 food poisoning events recorded by Poison Control Center Marseille involving four were further investigated as meal leftovers collected analyzed. A...
Vipera aspis (V.a.a.) is the most dangerous poisonous snake in South-Eastern France. The clinical symptoms observed after V.a.a. envenomations involve mostly local signs (pain, edema) associated more severe cases with systemic (gastro-intestinal and cardiovascular manifestations). Since 1992, several unusual of moderate `neurotoxic’ by snakes have been reported a very localized area Most human patients mainly suffered neurological owing to cephalic muscle paralysis. Drowsiness dyspnea were...
We report the simultaneous presence of two phospholipase A 2 (PLA ) neurotoxins in venom Vipera aspis , first such observation. One is monomeric and identical to ammodytoxin B ammodytes . Its may result from gene flux after interbreeding between V. The second, a novel heterodimer named vaspin, very similar vipoxin meridionalis PLA ‐I zinnikeri It expression preexisting genes, acidic subunit evolving an ancestor common ammodytin I2 which we also found
Soluble N -ethylmaleimide-sensitive fusion protein attachment receptor (SNARE) interactions at the synaptic vesicle/plasma membrane interface play an essential role in neurotransmitter release. The membrane-proximal region (amino acids 77–90) of v-SNARE vesicle-associated 2 (VAMP 2, synaptobrevin) binds acidic phospholipids or Ca 2+ /calmodulin a mutually exclusive manner, processes that are required for -dependent exocytosis. To address mechanisms involved, we asked whether this VAMP can...
Afin de renforcer et d’adapter un premier dispositif surveillance mis en place sur le pourtour mediterraneen francais au cours l’ete 2007, il etait necessaire faire point les connaissances disponibles effets d’Ostreopsis ovata, s’appuyant la demarche d’evaluation des risques sanitaires. O. ovata est une algue monocellulaire signalee plus frequemment Mediterranee, synthetisant toxine appelee palytoxine. Cette a l’origine survenue plusieurs cas groupes d’irritations, accompagnees toux, fievres...