A5078574918- Per- and polyfluoroalkyl substances research
- Toxic Organic Pollutants Impact
- Air Quality and Health Impacts
- Effects and risks of endocrine disrupting chemicals
- Atmospheric chemistry and aerosols
- Pharmaceutical and Antibiotic Environmental Impacts
- Reproductive biology and impacts on aquatic species
- Health, Environment, Cognitive Aging
- Social and Educational Sciences
- Nutritional Studies and Diet
- Mercury impact and mitigation studies
- Scientific Research and Discoveries
- Birth, Development, and Health
- Environmental Toxicology and Ecotoxicology
- Water Treatment and Disinfection
- Indigenous Studies and Ecology
- Chemical Analysis and Environmental Impact
- NMR spectroscopy and applications
- Atmospheric Ozone and Climate
- Chemistry and Chemical Engineering
- Microplastics and Plastic Pollution
- Thyroid Disorders and Treatments
- Delphi Technique in Research
- Quantum Electrodynamics and Casimir Effect
- Carcinogens and Genotoxicity Assessment
Swedish University of Agricultural Sciences
2020-2025
National Food Administration
2016-2025
Uppsala University
2008-2020
Phthalates and phenolic substances were investigated in urine samples from first-time mothers Uppsala, Sweden, collected between 2009 2014. These have a comparably fast metabolism urinary metabolites are predominantly analysed. The main aim was to investigate if measures decrease production use of certain phthalates bisphenol A (BPA) resulted decreased human exposure, determine exposures replacement chemicals increased. Temporal trends evaluated for (n=13) seven phthalates, phthalate...
A combined method for quantitative analysis, along with suspect and non-target screening of per- polyfluoroalkyl substances (PFAS) was developed using ultra-high pressure liquid chromatography-ultra-high resolution (Orbitrap) mass spectrometry. The applied together measurements total- extractable organofluorine (TF EOF, respectively), to pooled serum samples from 1996-2017 first-time mothers living in the county Uppsala, Sweden, some which (i.e. 148 472 women sampled 1996-2012) were exposed...
and polyfluoroalkyl substances (PFAS) may affect adolescent health, yet factors related to PFAS concentrations in serum are poorly understood. We studied demographic, life-style physiological determinants of Swedish adolescents from a nation-wide survey, Riksmaten Adolescents 2016–17 (RMA, age 10–21 years, n = 1098). Serum samples were analyzed for 42 PFAS, using liquid chromatography-tandem mass spectrometry. The cumulative probability model was used estimate associations between...
We investigated if maternal body burdens of perfluoroalkyl acids (PFAAs) at the time delivery are associated with birth outcome and early life exposure (in utero/nursing) is childhood growth weight gain. Maternal PFAA were estimated by analysis serum samples from mothers living in Uppsala County, Sweden (POPUP), sampled three weeks after between 1996 2011. Data on child length collected medical records converted into standard deviation scores (SDS). Multiple linear regression models...
Little is known about factors influencing infant perfluorinated alkyl acid (PFAA) concentrations. Associations between serum PFAA concentrations in 2–4-month-old infants (n = 101) and determinants were investigated by multiple linear regression general model analysis. In exclusively breast-fed infants, maternal 3 weeks after delivery explained 13% (perfluoroundecanoic acid, PFUnDA) to 73% (perfluorohexanesulfonate, PFHxS) of concentration variation. Median infant/maternal ratios decreased...
Per- and polyfluoroalkyl substances (PFASs) are a highly persistent, mobile, bioaccumulative class of chemicals, which emissions into the environment result in long-lasting contamination with high probability for causing adverse effects to human health environment. Within European Biomonitoring Initiative HBM4EU, samples data were collected harmonized way from biomonitoring (HBM) studies Europe derive current exposure across geographic spread. We performed mixture risk assessments based on...
Teratogenic properties of perfluoroalkyl substances (PFAS) have been assessed in a few studies, however, epidemiological evidence for an association is inconclusive. We conducted Swedish nation-wide register-based cohort study to assess the associations estimated fetal exposure sum drinking water perfluorooctane sulfonic acid (PFOS), perfluorooctanoic (PFOA), perfluorononanoic (PFNA) and perfluorohexane (PFHxS) with major congenital malformations. included all births Sweden during 2012-2018...
There is inconclusive evidence of associations between exposure to per- and polyfluoroalkyl substances (PFAS) diabetes hypertensive disorders during pregnancy. We conducted a nation-wide register-based cohort study assess the estimated maternal drinking water sum four major PFAS (PFAS4; perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), perfluorononanoate (PFNA) perfluorohexanoate (PFHxS)) with gestational mellitus (GDM), hypertension preeclampsia. included nulliparous women giving...
We investigated body burdens of persistent organic pollutants (POPs) in Swedish first-time mothers by measurements breast milk, and followed up the temporal trends between 1996 2017. POPs were analysed individual samples (n = 539) from participants Uppsala county, Sweden. This made it possible to adjust for age mother, pre-pregnancy BMI, weight gain during pregnancy, loss after delivery, education, main determinants POP burdens, apart sampling year. also compared observed with determined be...
Abstract The usefulness of Xenopus tropicalis as a model species to investigate endocrine disruption and developmental reproductive toxicity was assessed. In our test system tadpoles were exposed substances from shortly after hatching until metamorphosis, including the period gonadal differentiation. Effects on sex hormone thyroid axes evidenced skewed ratios, malformations organs, altered cytochrome (CYP19) (aromatase) activity, gene expression in gonads brain, well changed histology time...
We investigated associations between serum perfluoroalkyl acid (PFAA) concentrations in children aged 4, 8, and 12 years (sampled 2008–2015; n = 57, 55, 119, respectively) exposure via placental transfer, breastfeeding, ingestion of PFAA-contaminated drinking water. Sampling took place Uppsala County, Sweden, where the water has been historically contaminated with perfluorobutanesulfonate (PFBS), perfluorohexanesulfonate (PFHxS), perfluorooctanesulfonate (PFOS), perfluoroheptanoate (PFHpA),...
In order to improve human health risk assessment of perfluoroalkyl acids (PFAAs), demography/life-style/physiological factors and drinking water PFAA concentrations were investigated as possible determinants child serum concentrations.
Adolescence is a period of significant physiological changes, and likely sensitive window to chemical exposure. Few nation-wide population-based studies body burdens in adolescents have been published. In the national dietary survey Riksmaten Adolescents (RMA) 2016–17, over 13 substance groups, including elements, chlorinated/brominated/fluorinated persistent organic pollutants (POPs) were analysed blood, urine metabolites phthalates/phthalate alternatives, phosphorous flame retardants,...
There is inconclusive evidence for an association between per- and polyfluoroalkyl substances (PFAS) fetal growth. We conducted a nation-wide register-based cohort study to assess the associations of estimated maternal exposure sum (PFAS4) perfluorooctane sulfonic acid (PFOS), perfluorooctanoic (PFOA), perfluorononanoic (PFNA) perfluorohexane (PFHxS) with birthweight as well risk small- (SGA) large-for-gestational-age (LGA). included all births in Sweden during 2012–2018 mothers residing ≥...
Exposure to methylmercury (MeHg) through fish is a global public health problem. monitoring essential for risk assessment, especially in pregnant women and children due the documented neurotoxicity. Herein, we evaluate time series of MeHg exposure via primiparous Swedish women, covering period 23 years (1996–2019). The 655 included mothers were part POPUP study (Persistent Organic Pollutants Uppsala Primiparas) conducted by Food Agency (SFA). was assessed measurements total mercury (Hg) hair...
Contaminated drinking water (DW) is a major source of exposure to per- and polyfluoroalkyl substances (PFAS) at locations around PFAS production/use facilities military airports. This study aimed investigate quantitative relationships between concentrations in DW serum nine perfluoroalkyl acids (PFAAs) Swedish adult populations living near contamination hotspots. Short-chained (PFPeA, PFHxA, PFHpA, PFBS) long-chained PFAAs (PFOA, PFNA, PFDA, PFHxS PFOS) were measured serum. We matched for...