A5037971113- Air Quality and Health Impacts
- Effects and risks of endocrine disrupting chemicals
- Asthma and respiratory diseases
- Toxic Organic Pollutants Impact
- Per- and polyfluoroalkyl substances research
- Nutritional Studies and Diet
- Health, Environment, Cognitive Aging
- Birth, Development, and Health
- Allergic Rhinitis and Sensitization
- Cardiovascular Function and Risk Factors
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Epigenetics and DNA Methylation
- ECG Monitoring and Analysis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Indoor Air Quality and Microbial Exposure
- Heart Failure Treatment and Management
- Workplace Violence and Bullying
- Sexual Assault and Victimization Studies
- COVID-19 Clinical Research Studies
- Maternal and Perinatal Health Interventions
- Cardiac electrophysiology and arrhythmias
- Maternal Mental Health During Pregnancy and Postpartum
- Pediatric health and respiratory diseases
- Heart Rate Variability and Autonomic Control
- Noise Effects and Management
Uppsala University
2016-2025
Uppsala University Hospital
2009-2019
Stockholm County Council
2008
Institute of Pharmacology
1999
University of Naples Federico II
1979
The knowledge of the impact cardiovascular risk factors at different ages has mainly been based on studies performed ages. This study aimed to investigate change in traditional over aging process subjects followed for 4 decades.In ULSAM (Uppsala Longitudinal Study Adult Men) study, 2322 men originally investigated 1970 1974 have regarding diseases until end 2013. cohort physically 50, 60, 70, 77, and 82 years body mass index, low-density lipoprotein- high-density lipoprotein-cholesterol,...
Age-related changes in DNA methylation were observed cross-sectional studies, but longitudinal evidence is still limited. Here, we aimed to characterize age-related patterns using 1011 blood samples collected from 385 Swedish twins (age at entry: mean 69 and standard deviation 9.7, 73 monozygotic 96 dizygotic pairs) up five times (mean 2.6) over 20 years 8.7). We identified 1316 age-associated sites (P<1.3×10-7) a epigenome-wide association study design. measured how estimated cellular...
Abstract Background DNA methylation changes over life at specific sites in the genome, which can be used to estimate “biological age.” The aim of this population‐based longitudinal cohort study was investigate association between estimated biological age and incident cardiovascular disease ( CVD ). Materials methods Based on formulas published by Hannum et al Horvath al, age” calculated using data from Illumina 450k Bead Methylation chip 832 participants free Prospective Study Vasculature...
and polyfluoroalkyl substances (PFAS) may affect adolescent health, yet factors related to PFAS concentrations in serum are poorly understood. We studied demographic, life-style physiological determinants of Swedish adolescents from a nation-wide survey, Riksmaten Adolescents 2016–17 (RMA, age 10–21 years, n = 1098). Serum samples were analyzed for 42 PFAS, using liquid chromatography-tandem mass spectrometry. The cumulative probability model was used estimate associations between...
Importance Major depressive disorder (MDD) is an important risk factor of suicidal behavior, but the added burden behavior and MDD on patient societal level, including all-cause mortality, not well studied. Also, contribution various prognostic factors for has been quantified in larger samples. Objective To describe clinical outcomes, patients with to explore associated management inform future research guidelines. Design, Setting, Participants This population-based cohort study used health...
Client satisfaction is an essential component of quality care. Health system factors, processes care as well mothers' characteristics influence the extent to which meets expectations mothers and families. In our study, we specifically aimed address experiences of, with, during childbirth. A population-based cross-sectional using structured interviews with published sequences questions assessing satisfaction, including 4358 who gave birth 12 months before June 2016 estimate childbirth...
Periodontal disease has been associated with cardiovascular (CVD), but whether the response to treatment of periodontal affects this association not investigated in any large prospective study. data obtained at baseline and 1 y after were available 5,297 individuals remaining teeth who treated a specialized clinic for disease. Poor was defined as having >10% sites probing pocket depth >4 mm deep bleeding on ≥20% active treatment. Fatal/nonfatal incidence rate CVD (composite end point...
To investigate whether users of hormonal contraceptives (HCs) are at increased risk depression compared with non-users.Register-based cohort study.Sweden.Women aged 15-25 years between 2010 and 2017 no prior antidepressant treatment, psychiatric diagnose or contraindication for HCs (n = 739 585).Women a prescription HC were identified via the Swedish Prescribed Drug Register (SPDR). Relative risks (RRs) first diagnosis in current HC-users non-users modelled by Poisson regression. Adjustments...
Since the beginning of Covid-19 pandemic, scientific community has explored determinants Covid 19 disease severity. However, majority studies are based on in-hospital patients with high risk collider- or selection bias. The present investigation details factors associated overall mortality, hospitalization and intensive care unit (ICU) admission in infections, complete population coverage high-resolution data patient characteristics comorbid conditions This population-based observational...
To cite this article: Cai G‐H, Hashim JH, Z, Ali F, Bloom E, Larsson L, Lampa Norbäck D. Fungal DNA, allergens, mycotoxins and associations with asthmatic symptoms among pupils in schools from Johor Bahru, Malaysia. Pediatr Allergy Immunol 2011; 22 : 290–297. Abstract While there is a large variation of prevalence asthma worldwide, what we do know that it on the rise developing countries. However, are few studies moulds mycotoxin exposure tropical The aims were to measure selected fungal...
We investigated if maternal body burdens of perfluoroalkyl acids (PFAAs) at the time delivery are associated with birth outcome and early life exposure (in utero/nursing) is childhood growth weight gain. Maternal PFAA were estimated by analysis serum samples from mothers living in Uppsala County, Sweden (POPUP), sampled three weeks after between 1996 2011. Data on child length collected medical records converted into standard deviation scores (SDS). Multiple linear regression models...
There is a need to evaluate complex interaction effects on human health, such as those induced by mixtures of environmental contaminants. The usual approach formulate an additive statistical model and check for departures using product terms between the variables interest. In this paper, we present search among several boosted regression trees. We simulate continuous outcome from real data 27 contaminants, some which are correlated, test method's ability uncover simulated interactions....
The impact of most, but not all, cardiovascular risk factors decline by age. We investigated how the metabolic syndrome (MetS) was related to disease (CVD) during 40 years follow-up in Uppsala Longitudinal Study Adult Men (ULSAM, 2,123 men all aged 50 at baseline with reinvestigations age 60, 70, 77 and 82). strength MetS as a factor incident combined end-point three outcomes declined ageing, well for myocardial infarction, ischemic stroke heart failure when analysed separately. For CVD,...
Abstract Myocardial infarction diagnosis is a common challenge in the emergency department. In managed settings, deep learning-based models and especially convolutional have shown promise electrocardiogram (ECG) classification, but there lack of high-performing for myocardial real-world scenarios. We aimed to train validate learning model using ECGs predict department patients. studied patients Stockholm region between 2007 2016 that had an ECG obtained because their presenting complaint....
We investigated the impact of time to adjuvant chemotherapy (AC) on survival after surgical resection (<8 weeks or 8-16 weeks) for patients with non-small cell lung cancer (NSCLC) by applying a target-trial emulation. used Swedish population-based healthcare registries emulate hypothetical target trial, treatment arms 'initiate AC <8 postoperatively' and postoperatively'. The clone-censor-weight approach was in which all were cloned clones assigned each arm. Clones then censored when no...
To follow-up lung function and airway symptoms in workers exposed to cobalt dust at a hard metal plant.A total of 582 employees underwent spirometry completed questionnaire. A historical exposure matrix was created, assigning figures for recent work-related exposure.At the time employment, 5% reported from respiratory tract. At follow-up, suffered persistent coughing 7% asthma; 20% were daily smokers. Among nonsmokers without asthma, an evident, statistically nonsignificant, dose-response...
Summary: From the lectures presented at 2nd International Workshop on Obesity and Environmental Contaminants, which was held in Uppsala, Sweden, 8–9 October 2015, it became evident that findings from numerous animal epidemiological studies are consistent with hypothesis environmental contaminants could contribute to global obesity epidemic. To increase awareness of this important issue among scientists, regulatory agencies, politicians, chemical industry management, general public, authors...
Study objectives Obesity is often associated with lower lung function; however, the interaction of function central obesity and physical inactivity less clear. As such, we investigated effect on body size (body mass index (BMI)), (waist circumference (WC)) self-reported activity. Methods Lung function, height, weight WC were measured in 22 743 participants (12 791 women), aged 45–75 years, from EpiHealth cohort study. Physical activity, gender educational level assessed using a...
Abstract Background Insufficient reductions in maternal and neonatal deaths stillbirths the past decade are a deterrence to achieving Sustainable Development Goal 3. The majority of occur during intrapartum immediate postnatal period. Overcoming knowledge-do-gap ensure implementation known evidence-based interventions this period has potential avert at least 2.5 million mothers their offspring annually. This paper describes study protocol for implementing evaluating multi-faceted health care...