A5017170377- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Carcinogens and Genotoxicity Assessment
- Air Quality and Health Impacts
- Environmental Toxicology and Ecotoxicology
- Per- and polyfluoroalkyl substances research
- Analytical Chemistry and Chromatography
- Pharmacogenetics and Drug Metabolism
- Mercury impact and mitigation studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Atmospheric chemistry and aerosols
- Drug Transport and Resistance Mechanisms
- Microplastics and Plastic Pollution
- Chemical Reaction Mechanisms
- Chemical Analysis and Environmental Impact
- Estrogen and related hormone effects
- Chemical Synthesis and Reactions
- Chemical Reactions and Isotopes
- Chemistry and Chemical Engineering
- Microbial bioremediation and biosurfactants
- Environmental Chemistry and Analysis
- Eicosanoids and Hypertension Pharmacology
- Neuroscience and Neuropharmacology Research
- Metabolomics and Mass Spectrometry Studies
- Health, Environment, Cognitive Aging
Örebro University
2017-2025
Stockholm University
2014-2024
Tongji University
2014-2022
State Key Laboratory of Pollution Control and Resource Reuse
2015-2021
Shanghai Institute of Pollution Control and Ecological Security
2019
Karolinska Institutet
1978-2018
Södertälje Sjukhus
2015
European Food Safety Authority
2015
Norwegian Veterinary Institute
2010
Swedish Museum of Natural History
1995-2010
Brominated flame retardants such as polybrominated diphenyl ethers (PBDEs), pentabromophenol (PBP), and tetrabromobisphenol A (TBBPA) are produced in large quantities for use electronic equipment, plastics, building materials. Because these compounds have some structural resemblance to the thyroid hormone thyroxine (T4), it was suggested that they may interfere with metabolism transport, e.g., by competition T4 on transthyretin (TTR). In present study, we investigated possible interaction of...
Polybrominated diphenyl ethers (PBDEs) are used in large quantities as additive flame retardants plastics and textile materials. PBDEs persistent compounds have been detected wildlife human adipose tissue plasma samples. In this study, we investigated the (anti)estrogenic potencies of several PBDE congeners, three hydroxylated (HO-PBDEs), differently brominated bisphenol A different cell line assays based on estrogen receptor (ER)-dependent luciferase reporter gene expression. T47D breast...
Air samples from a plant engaged in recycling electronics goods, factory assembling printed circuit boards, computer repair facility, offices equipped with computers, and outdoor air have been analyzed respect to their content of brominated hydrocarbon phosphate ester flame retardants. Polybrominated diphenyl ethers, polybrominated biphenyls, 1,2-bis(2,4,6-tribromophenoxy)ethane, tetrabromobisphenol A, organophosphate esters were all detected the indoor samples, highest concentrations being...
Abstract A previously described method for analysis of organochlorine compounds in human milk was adopted brominated diphenyl ethers ( BDEs) substituted with three to six bromine atom s. Analytes were extracted from hum an the lipophilic gel Lipidex 5000. Further purifications performed on partly deactivated aluminum oxide and silica columns, followed by permeation chromatography. The concentrations BDEs determined gas chromatography/mass spectrometry (GC/MS). average recoveries...
Ever since the interest in organic environmental contaminants first emerged 50 years ago, there has been a need to present discussion of such chemicals and their transformation products using simple abbreviations so as avoid repetitive use long chemical names. As number concern increased, also increased dramatically, sometimes resulting different for same chemical. In this article, we propose flame retardants (FRs) substituted with bromine or chlorine atoms including functional group...
Among all brominated flame retardants in use, the polybrominated diphenyl ethers (PBDEs) have been identified as being of particular environmental concern due to their global distribution and bioaccumulating properties, observed humans wildlife worldwide. Still there is a need for more data on basic characteristics PBDEs better understand describe fate. Hence, aim this study was investigate photochemical degradation with different degrees bromination. The 15 individual substituted 4−10...
The aim of this study was to determine human prenatal and postnatal exposures polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), hydroxylated metabolites PCBs (polychlorobiphenylols; OH-PCBs), pentachlorophenol (PCP). median PBDE fresh-weight concentrations in maternal cord blood plasma breast milk were 24, 4.3, 75 pg/g, respectively. PCB approximately 60 times higher each compartment (1,560, 277, 4,310 respectively). Calculated on a lipid weight basis, the levels...
Polychlorinated biphenyls (PCBs) are persistent environmental pollutants which exert a variety of toxic effects in animals, including disturbances sexual development and reproductive function. The estrogenic PCBs may be mediated part by hydroxylated PCB metabolites (PCB-OHs), but the mechanisms they brought about not understood. as well PCB-Hs show low affinities for both alpha beta estrogen receptor isoforms. In present study we demonstrate that various environmentally relevant PCB-OHs...
Polybrominated diphenyl ethers (PBDEs) are used as additives in polymers and textiles to prohibit the development of fires. Because production use PBDEs, their lipophilic characteristics, persistence, these compounds have become ubiquitous environmental contaminants. The aim present study was determine potential exposures PBDEs clerks working full-time at computer screens personnel an electronics-dismantling plant, with hospital cleaners a control group. Five PBDE...
Polychlorinated biphenyls (PCBs) are important environmental contaminants, and their toxicity to wildlife humans of major concern. PCBs form persistent abundant metabolites, PCB methyl sulfones, that accumulate in biota. We now report certain hydroxylated metabolites show a strong selective accumulation mammalian blood. Plasma from experimentally PCB-dosed rats blood environmentally exposed grey seals (Halichoerus grypus) were analyzed. Among all possible may be formed, only few, dominated...
The aim of the present study was to model apparent serum half-lives polybrominated diphenyl ethers (PBDEs) with 7-10 bromine substituents. Workers occupational exposure PBDEs have elevated levels PBDEs, but these substances are also found in general population and ubiquitous environmental contaminants. calculations were based on assessments rubber workers (manufactured flame-retarded compound) electronics dismantlers who donated blood during a period no work-related exposures referents...
Methoxylated polybrominated diphenyl ethers (MeO-PBDEs) and hydroxylated PBDEs (OH-PBDEs) have recently been identified in fish wildlife from the Baltic Sea. Both OH-PBDEs MeO-PBDEs are known natural products, while also may be metabolites of PBDEs. The aim present study was to determine if red macroalga Ceramium tenuicorne could a source for MeO- environment. Blue mussels (Mytilus edulis) same area were investigated their content OH-PBDEs. Seven four both blue mussels. contained...
Our aim was to investigate exposure polybrominated diphenyl ethers (PBDEs) in a young urban population developing country, with focus on potentially highly exposed children working informally as scrap scavengers at large municipal waste disposal site. We also set out whether hydroxylated metabolites, which not hitherto have been found retained humans, could be detected.We assessed PBDEs pooled serum samples obtained 2002 from 11-15 years of age, and sometimes living the site Managua,...