The totality of the societal and individual impact treatment-resistant depression (TRD) is unknown, as potential to prognosticate TRD. generalizability many observational studies on TRD limited.To estimate burden in a large population-wide cohort an area with universal health care by including data from both types (psychiatric nonpsychiatric) and, further, develop prognostic model for clinical use.This study, population-based assessed Stockholm MDD Cohort episodes major depressive disorder...

Importance Nonsuicidal self-injury is prevalent in adolescence and associated with adverse clinical outcomes. Effective interventions that are brief, transportable, scalable lacking. Objective To test the hypotheses an internet-delivered emotion regulation individual therapy for adolescents delivered adjunctive to treatment as usual superior only reducing nonsuicidal improvements mediate these effects. Design, Setting, Participants This 3-site, single-masked, randomized superiority trial...

Importance Major depressive disorder (MDD) is an important risk factor of suicidal behavior, but the added burden behavior and MDD on patient societal level, including all-cause mortality, not well studied. Also, contribution various prognostic factors for has been quantified in larger samples. Objective To describe clinical outcomes, patients with to explore associated management inform future research guidelines. Design, Setting, Participants This population-based cohort study used health...

ABSTRACT Objective The study aimed to estimate 5‐year recurrence rates of first‐episode major depressive disorder (MDD) and assess the impact adolescence on likelihood after first episode, compared adults. Methods A pre‐registered retrospective cohort that utilized epidemiological data from Stockholm MDD Cohort (1997–2018), including all individuals registered with a depression diagnosis in Region 2010 2018. This dataset combines longitudinal information primary secondary care, socioeconomic...

Nonsuicidal self-injury (NSSI) is common among adolescents and associated with negative outcomes. However, treatments developed specifically for NSSI the proposed disorder (NSSID) are scarce, access to empirically supported in many areas limited. Online carry potential increase availability of evidence-based treatments. Emotion regulation individual therapy (ERITA) has shown promise treatment NSSID. The present study examined feasibility, acceptability, utility an online version ERITA....

<h3>Importance</h3> Individuals who self-harm may have an increased risk of aggression toward others, but this association has been insufficiently investigated. More conclusive evidence affect assessment, treatment interventions, and clinical guidelines. <h3>Objective</h3> To investigate the between nonfatal violent crime. <h3>Design, Setting, Participants</h3> This population-based longitudinal cohort study, conducted from January 1, 1997, through December 31, 2013, studied all Swedish...

Nonsuicidal self-injury (NSSI) is a serious health risk behavior that forms the basis of tentative diagnosis in DSM-5, NSSI Disorder (NSSID). To date, established treatments specific to or NSSID are scarce. As first step evaluating feasibility, acceptability, and utility novel treatment for adolescents with NSSID, we conducted an open trial emotion regulation individual therapy (ERITA): 12-week, behavioral aimed at directly targeting both its proposed underlying mechanism difficulties....

Obsessive-compulsive disorder (OCD) is associated with increased mortality, but the causes of this increase are poorly understood. This study examined whether OCD an risk metabolic and cardiovascular complications.Individuals diagnosed (n = 25,415) were identified from a cohort 12,497,002 individuals living in Sweden between 1973 2013. Cox proportional hazard regression analyses used to investigate complications patients compared general population unaffected full siblings individuals....

Family and twin studies of Borderline Personality Disorder (BPD) have found familial aggregation genetic propensity for BPD, but estimates vary widely. Large-scale family clinically diagnosed BPD are lacking. Therefore, we performed a total-population study estimating the heritability BPD. We followed 1,851,755 individuals born 1973-1993 in linked Swedish national registries. BPD-diagnosis was ascertained between 1997 2013, 11,665 received BPD-diagnosis. identified relatives estimated sex...

Background Pharmacoepidemiological studies have long raised concerns on widespread use of benzodiazepines and benzodiazepine-related drugs (BZDs), in particular long-term use, among adults the elderly. In contrast, evidence pertaining to rates BZD at younger ages is still scarce, factors that influence utilisation shape different prescribing patterns youths remain largely unexplored. We examined prevalence rates, relative changes over time, for dispensation young people aged 0–24 years...

Abstract O bjective Investigating unique and shared aspects of measures emotion regulation (ER) advances our understanding ER as a multidimensional construct. This study aimed to investigate psychometric properties three ER‐measures: Difficulties in Emotion Regulation Scale (DERS‐36), the abbreviated version DERS‐16, Questionnaire (ERQ). Methods In community sample ( N = 843; 56% females) we investigated their internal consistency, factor structure, convergence, association with symptoms...

Abstract There is concern that selective serotonin reuptake inhibitor (SSRI) treatment may increase the risk of suicide attempts or deaths, particularly among children and adolescents. However, debate remains regarding nature relationship. Using nationwide Swedish registers, we identified all individuals aged 6–59 years with an incident SSRI dispensation ( N = 538,577) from 2006 to 2013. To account for selection into treatment, used a within-individual design compare deaths (suicidal...

Objective: The authors examined associations between medications for alcohol and opioid use disorders (acamprosate, naltrexone, methadone, buprenorphine) suicidal behavior, accidental overdoses, crime. Method: In this total population cohort study, 21,281 individuals who received treatment with at least one of the four 2005 2013 were identified. Data on medication outcomes collected from Swedish population-based registers. A within-individual design (using stratified Cox proportional hazards...

Previous research has noted trends of increasing internalizing problems (e.g., symptoms depression and anxiety), particularly amongst adolescent girls. Cross-cohort comparisons using identical assessments both anxiety in youth are lacking, however.In this large twin study, we examined samples 9 year old children 15 adolescents, gathered from successive birth cohorts 1998 to 2008 (age 9) 1994-2001 15). Assessments at age were parent-rated, self- parent-rated. We (i) the relation between...

Objective Emotion regulation group therapy (ERGT) has shown promising results in several efficacy trials. However, it not been evaluated outside a research setting. In order to increase the availability of empirically supported treatments for individuals with borderline personality disorder and deliberate self-harm, an evaluation ERGT routine clinical care was conducted therapists different professional backgrounds who had received brief intensive training prior trial onset. Design...

This study examines trends in antidepressant drug dispensations among young people aged 0-24 years Sweden during the period 2006-2013, as well prescription patterns and central nervous system (CNS) polypharmacy with antidepressants. Using linkage of Swedish national registers, we identified all residents that collected at least one (here defined users) between 1 January 2006 31 December 2013 (n = 174,237), categorized them children (0-11 years), adolescents (12-17 adults (18-24 years)....

Missing diagnostic information often results poor accuracy of the clinical decision process. The Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID) is a short standardized interview covers rather broad range diagnoses applicable to children adolescents. MINI-KID disorder classifications have shown test-retest reliability validity comparable other interviews claimed be useful tool screening in Child Adolescent Psychiatric care. concordance between Swedish...

Background More knowledge about risks of clinical outcomes associated with nonsuicidal self‐injury (NSSI) and suicide attempts (SAs) is needed to inform risk assessment intervention. Methods Longitudinal cohort study based on 1,855 youths was clinically assessed for NSSI SA, followed up (from December, 2011 December 2013) the outcomes; diagnosed self‐injury, alcohol/substance use disorder, psychiatric inpatient care data derived from Swedish registers. Hazard ratios (HRs) 95% confidence...

Objective: Suicide attempts are common in youth and have potentially lethal outcomes. Effective treatments targeting suicide scarce. The objective was to assess the feasibility of a family-based cognitive-behavioral treatment relative an active control for with suicidal behavior. Method: Thirty youths (93% female; mean [SD] age=14.6 [1.5] years) residing Sweden recent behavior (last 3 months) at least one parent per were randomized 12 weeks Safe Alternatives Teens Youths (SAFETY) or...

Individuals who engage in non-suicidal self-injury (NSSI) exhibit reduced pain sensitivity compared to the general population. It has been argued that this hypoalgesic characteristic may be attributable hyper-effective modulation; however, empirical support for theory remains inconsistent. The aim of study was use a combined offset analgesia (OA) and onset hyperalgesia (OH) protocol investigate if women with NSSI have propensity inhibit nociceptive signals higher degree (stronger OA...

Objective: Suicide attempts are common in youth and have potentially lethal outcomes. Effective treatments targeting suicide scarce. The objective was to assess the feasibility of a family-based cognitive-behavioral treatment relative an active control for with suicidal behavior. Method: Thirty youths (93% female; mean [SD] age=14.6 [1.5] years) residing Sweden recent behavior (last 3 months) at least one parent per were randomized 12 weeks Safe Alternatives Teens Youths (SAFETY) or...

Little is known about sex differences in outcomes of self-harm, and there are inconclusive results concerning the association between sex, suicide attempts. The aim this study was to explore self-harm adolescence. In cohort study, all individuals (0-17 years) enrolled at child- adolescent mental health services (CAMHS) Stockholm 2001 2015 (N = 110,072) were followed national registers from their last contact with CAMHS, until end 2015. Exposure as reason for contact, outcome measures were:...

Abstract A systematic review and meta-analysis was conducted where we evaluated the effects of Parent Management Training (PMT), Parent–Child Interaction Therapy (PCIT) PMT combined with child cognitive behavioral therapy (CBT) using data from 25 RCTs on children clinical levels disruptive behavior (age range 2–13 years). Results showed that ( g = 0.64 [95% CI 0.42, 0.86]) PCIT 1.22 0.75, 1.69]) were more effective than waiting-list (WL) in reducing parent-rated behavior, also improving...