<b>Objective</b> To assess the risk of attempted suicide before, during, and after treatment with isotretinoin for severe acne. <b>Design</b> Retrospective cohort study linking a named patient register users (1980-9) to hospital discharge cause death registers (1980-2001). <b>Setting</b> Sweden, 1980-2001. <b>Population</b> 5756 patients aged 15 49 years prescribed acne observed 17 197 person 2905 87 120 treatment. <b>Main outcome measures</b> Standardised incidence ratio (observed number...

Major depression occurs in 5–10% of pregnancies and is associated with many negative effects for mother child, yet treatment options are scarce. To our knowledge, this the first published randomised controlled trial on Internet delivered Cognitive Behavior Therapy (ICBT) group. test efficacy a pregnancy adapted version an existing 10-week ICBT-program as well assessing acceptability adherence Randomised trial. Online telephone. Self-referred pregnant women (gestational week 10–28 at intake)...

Objectives. Immunological differences have previously been associated with depression and suicidal behaviour. Several cytokines identified as potentially important in understanding the pathophysiology of mood disorders suicidality. Here we aimed to identify new inflammatory biomarkers for suicide prediction. Methods. Plasma concentrations interleukin (IL) 1-a , IL1-b, IL-2, IL-4, IL-6, IL-8, IL-10, interferon-gamma (IFNG), tumor necrosis factor-a (TNF-a), monocyte chemotactic protein-1...

A dysregulated immune system influencing pathways for cytokine regulation and growth factor expression is implicated in the pathophysiology of several neuropsychiatric disorders. Here, we analyzed cerebrospinal fluid (CSF) cytokines factors with an ultra-sensitive immunoassay 43 medication-free suicide attempters 20 healthy male volunteers. CSF vascular endothelial (VEGF) interleukin-8 (IL-8) levels were significantly lower compared controls. Further, VEGF showed a significant negative...

Nonsuicidal self-injury (NSSI) is common among adolescents and associated with negative outcomes. However, treatments developed specifically for NSSI the proposed disorder (NSSID) are scarce, access to empirically supported in many areas limited. Online carry potential increase availability of evidence-based treatments. Emotion regulation individual therapy (ERITA) has shown promise treatment NSSID. The present study examined feasibility, acceptability, utility an online version ERITA....

There is a paucity of studies on the role early risk factors for choice methods violent suicide attempts. Adolescent or non-violent attempts and subsequent were studied using longitudinal design.A national Swedish cohort 48 834 18-20-year-old young men conscripted military service from 1969 to 1970 was followed through official registers during 37-year period. Two questionnaires concerning their psychosocial background answered by each conscript. Cox proportional hazard regression analyses...

The dysregulation of inflammation has been associated with depression and, more recently, suicidal behaviors. reports regarding the relationship between interleukin-6 (IL-6) and suicide attempts are inconsistent. Personality traits such as impulsivity aggression considered endophenotypes important factors that underlie aim current study was to assess whether plasma cerebrospinal fluid (CSF) levels IL-6 personality among attempters. We assessed relationships traits, violent attempts. CSF were...

<h3>Importance</h3> Individuals who self-harm may have an increased risk of aggression toward others, but this association has been insufficiently investigated. More conclusive evidence affect assessment, treatment interventions, and clinical guidelines. <h3>Objective</h3> To investigate the between nonfatal violent crime. <h3>Design, Setting, Participants</h3> This population-based longitudinal cohort study, conducted from January 1, 1997, through December 31, 2013, studied all Swedish...

Nonsuicidal self-injury (NSSI) is a serious health risk behavior that forms the basis of tentative diagnosis in DSM-5, NSSI Disorder (NSSID). To date, established treatments specific to or NSSID are scarce. As first step evaluating feasibility, acceptability, and utility novel treatment for adolescents with NSSID, we conducted an open trial emotion regulation individual therapy (ERITA): 12-week, behavioral aimed at directly targeting both its proposed underlying mechanism difficulties....

Suicide is a major public health concern globally. Accurately predicting suicidal behavior remains challenging. This study aimed to use machine learning approaches examine the potential of Swedish national registry data for prediction behavior.The sample consisted 541,300 inpatient and outpatient visits by 126,205 Sweden-born patients (54% female 46% male) aged 18 39 (mean age at visit: 27.3) years psychiatric specialty care in Sweden between January 1, 2011 December 31, 2012. The most...

Abstract Advanced psychiatric treatments remain uncertain in preventing suicide among adolescents. Across the 21 Swedish regions, using nationwide registers between 2016–2020, we found negative correlation adolescent excess mortality (AESM) and regional frequencies of clozapine, ECT, lithium (CEL) usage adolescents (β = −0.613, p 0.0003, 95% CI: −0.338, −0.889) males −0.404, 0.009, −0.130, −0.678). No was females ( 0.197). Highest CEL male seen regions with lowest quartile (Q1) AESM (W 74,...

Article AbstractBackground: Both childhood trauma and violent behavior are important risk factors for suicidal behavior. The aim of the present study was to construct validate a clinical rating scale that could measure both exposure expression violence in during adult life ability Karolinska Interpersonal Violence Scale (KIVS) predict ultimate suicide attempters. Method: A total 161 attempters 95 healthy volunteers were assessed with KIVS measuring expressed (between 6-14 years age) (15 or...

Article AbstractObjective: Released prisoners have high suicide rates compared with the general population, but little is known about risk factors and possible causal pathways. We conducted a population-based cohort study to investigate for in people previously imprisoned.Method: identified individuals released from prison Sweden between January 1, 2005, December 31, 2009, through linkage of national registers. were followed day release until death, emigration, new incarceration, or 2009....

The aim of this study, comprising 88 suicide attempters, was to identify hypothalamic-pituitary-adrenal (HPA) -axis coupled CpG-sites showing methylation shifts linked severity the attempt. Candidate loci were further investigated as risk for a general psychiatric score in two cohorts adolescents (cohort 1 and 2). genome-wide pattern measured whole blood using Illumina Infinium Methylation EPIC BeadChip. Subjects stratified into high-risk low-risk groups based on suicidal behavior. We...

The aim of this pilot study was to investigate the feasibility and effectiveness a new psychoeducative intervention program (PEGASUS) for adults with ADHD their significant others in psychiatric outpatient context. At three clinics, took part PEGASUS, psychoeducational based on theories from cognitive behavioral therapy, neuropsychology, cross-disciplinary evidence regarding ADHD. In total, 108 were allocated treatment (51 57 others). Feasibility evaluated suitability at clinic completion....