A5044763213- Bone health and osteoporosis research
- Schizophrenia research and treatment
- Physical Activity and Health
- Hip and Femur Fractures
- Body Composition Measurement Techniques
- Nutrition and Health in Aging
- Suicide and Self-Harm Studies
- Neurotransmitter Receptor Influence on Behavior
- Social and Educational Sciences
- Electroconvulsive Therapy Studies
- Obesity, Physical Activity, Diet
- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
- Treatment of Major Depression
- Bone health and treatments
- Balance, Gait, and Falls Prevention
- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebral Palsy and Movement Disorders
- Cardiovascular and exercise physiology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Stress Responses and Cortisol
- Bipolar Disorder and Treatment
- Medical Imaging Techniques and Applications
- Sports Performance and Training
UiT The Arctic University of Norway
2018-2025
Mid Sweden University
2022-2025
Uppsala University
2024-2025
Umeå University
2015-2024
Karolinska Institutet
2008-2024
Uppsala University Hospital
2023-2024
Roche (Switzerland)
2020-2022
University College Cork
2021
Norwegian School of Sport Sciences
2021
University of Gothenburg
2009-2020
• Several groups have reported increased densities of D<sub>2</sub>dopamine receptors in the basal ganglia schizophrenic brains postmortem. The significance this finding has been questioned, since an upregulation receptor number may be a neuronal response to neuroleptic drug treatment. We used positron emission tomography and [<sup>11</sup>C]raclopride examine central binding 20 healthy subjects 18 newly admitted, young, neuroleptic-naive patients with schizophrenia. An vivo saturation...
Context:We have previously found that visceral fat is a stronger predictor for cardiovascular risk factors than body mass index (BMI).
Background Traumatic brain injury (TBI) has been associated with dementia. The questions of whether the risk dementia decreases over time after TBI, it is similar for different TBI types, and influenced by familial aggregation are not well studied. Methods findings cohort considered inclusion comprised all individuals in Sweden aged ≥50 years on December 31, 2005 (n = 3,329,360). Diagnoses were tracked through nationwide databases from 1964 until 2012. In a first cohort, diagnosed 164,334)...
Objective To investigate the association between traumatic brain injuries (TBIs) and risk of young onset dementia (YOD), that is, before 65 years age. Methods The study cohort comprised 811,622 Swedish men (mean age = 18 years) conscripted for military service 1969 1986. TBIs, dementia, covariates were extracted from national registers. Time‐dependent exposures using Cox proportional hazard regression models evaluated. Results During a median follow‐up period 33 years, there 45,249 with at...
Background Little is known about the short-term and long-term sequelae of concussion, when athletes who have sustained such injuries can safely return to play. Purpose To examine whether sports-related concussion increases risk subsequent injury in elite male football players. Study design Prospective cohort study. Methods Injuries were registered for 46 teams 10 European countries 2001/2002–2011/2102 seasons. Two survival models used analyse increased an first year. Results During follow-up...
To investigate the long-term risk of Parkinson disease (PD) after depression and evaluate potential confounding by shared susceptibility to 2 diagnoses.The nationwide study cohort included 140,688 cases depression, matched 1:3 using a nested case-control design temporal aspects parameters (total, n = 562,631). Potential familial coaggregation diagnoses was investigated in subcohort 540,811 sibling pairs. Associations were multivariable adjusted statistical models.During median follow-up...
Sarcopenia has been defined as age-related loss of muscle mass and function. The aim this randomized controlled trial was to examine the effects a 10-week instructor-led resistance training program on functional strength body composition in men women aged 70 years with pre-sarcopenia.Participants were either 10 weeks physical regimen including optional nutritional supplementation (n = 36) or control group 34) (ClinicalTrials.gov, no. NCT03297632). main outcome changes Short Physical...
Abstract We conducted a nationwide, registry-based study to investigate the importance of 34 potential risk factors for coronavirus disease 2019 (COVID-19) diagnosis, hospitalization (with or without intensive care unit [ICU] admission), and subsequent all-cause mortality. The population comprised all COVID-19 cases confirmed in Sweden by mid-September 2020 (68,575 non-hospitalized, 2494 ICU hospitalized, 13,589 non-ICU hospitalized) 434,081 randomly sampled general-population controls....
The effectiveness of heterologous prime-boost Coronavirus disease 2019 (Covid-19) vaccination is currently unknown.
Central D1, D2, and 5-HT2 receptor occupancy in schizophrenic patients treated with clozapine was determined related to serum concentrations.Seventeen (125-600 mg/day) were examined positron emission tomography (PET) one three of the following selective radioligands: [11C]SCH23390 (N = 11), [11C]raclopride 16), [11C]N-methylspiperone 5). Clozapine concentration by gas chromatography/mass spectrometry.D2 (20%-67%) lower than that previously classical neuroleptics (70%-90%). D1 (36%-59%)...
Recent genome-wide association studies (GWAS) have identified multiple risk loci for common obesity (FTO, MC4R, TMEM18, GNPDA2, SH2B1, KCTD15, MTCH2, NEGR1 and PCSK1). Here we extend those by examining associations with adiposity type 2 diabetes in Swedish adults. The nine single nucleotide polymorphisms (SNPs) were genotyped 3885 non-diabetic 1038 diabetic individuals available measures of height, weight body mass index (BMI). Adipose distribution objectively assessed using dual-energy...
Context: Abdominal obesity is an established risk factor for cardiovascular disease (CVD). However, the correlation of dual-energy x-ray absorptiometry (DEXA) measurements regional fat mass with CVD factors has not been completely investigated. Objective: The aim this study was to investigate association estimated mass, measured DEXA and factors. Design, Setting, Participants: This a cross-sectional 175 men 417 women. were performed on all subjects, who subsequently participated in community...
<b>Objective</b> To investigate relation between inpatient length of stay after hip fracture and risk death hospital discharge. <b>Setting</b> Population ≥50 years old living in Sweden as 31 December 2005 with a first the 2006-12. <b>Participants</b> 116 111 patients an incident from closed nationwide cohort. <b>Main outcome measure</b> Death within 30 days discharge to adjustment for multiple covariates. <b>Results</b> Mean decreased 14.2 2006 11.6 2012 (P<0.001). The association was...
AimsCardiovascular disease is the leading cause of morbidity and mortality worldwide, signs atherosclerosis are present in all large arteries already adolescence. We investigated association between high physical fitness late adolescence myocardial infarction (MI) later life.