Petra J. M. Elders
A5036526464- Bone health and osteoporosis research
- Metabolomics and Mass Spectrometry Studies
- Pharmaceutical Practices and Patient Outcomes
- Diabetes Treatment and Management
- Chronic Disease Management Strategies
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes Management and Research
- Diabetes Management and Education
- Genetic Associations and Epidemiology
- Hip and Femur Fractures
- Medication Adherence and Compliance
- Balance, Gait, and Falls Prevention
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Clinical practice guidelines implementation
- Blood Pressure and Hypertension Studies
- Diet and metabolism studies
- Sleep and related disorders
- Liver Disease Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Metabolism, Diabetes, and Cancer
- Diabetic Foot Ulcer Assessment and Management
- Vitamin D Research Studies
- Obesity and Health Practices
- Obesity, Physical Activity, Diet
- Cardiac Arrest and Resuscitation
Amsterdam University Medical Centers
2018-2025
Vrije Universiteit Amsterdam
2011-2025
Public Health Service of Amsterdam
2022-2025
University of Amsterdam
1993-2025
EMGO Institute for Health and Care Research
2014-2024
Amsterdam UMC Location VUmc
2015-2024
Amsterdam University of Applied Sciences
2022-2024
Huisarts en Wetenschap
2019-2024
Leiden University Medical Center
2024
Erasmus MC
2023
Background: Nonadherence with medication is a complex and multidimensional health care problem. The causes may be related to the patient, treatment, and/or provider. As consequence, substantial numbers of patients do not benefit optimally from pharmacotherapy, resulting in increased morbidity mortality as well societal costs. Several interventions contribute improved adherence. However, most have only modest effect. Thus, despite many efforts made, there has been little progress made yet...
Social jetlag represents the discrepancy between circadian and social clocks, which is measured as difference in hours midpoint of sleep work days free days. Previous studies have shown to be associated with body mass index (BMI), glycated hemoglobin levels, heart rate, depressive symptoms, smoking, mental distress alcohol use. The objective our current study was investigate, a group 145 apparently healthy participants (67 men 78 women, aged 18-55 years, BMI 18-35 kg/m(2)), prevalence its...
Ambulatory measurements of trunk accelerations can provide valuable information on the amount and quality daily-life activities contribute to identification individuals at risk falls. We compared associations between retrospective prospective falls with potential factors as measured by accelerometry. In addition, we investigated predictive value these parameters for 6-month One week accelerometry (DynaPort MoveMonitor) was obtained in 169 older adults (mean age 75). The daily activity gait...
Only a few studies have investigated the metabolic consequences of social jetlag. Therefore, we examined association jetlag with syndrome and type 2 diabetes mellitus in population-based cohort. We used cross-sectional data from New Hoorn Study cohort ( n = 1585, 47% men, age 60.8 ± 6 years). Social was calculated as difference midpoint sleep (in hours) between weekdays weekend days. Poisson linear regression models were to study associations, regarded possible effect modifier. adjusted for...
Associations between human genetic variation and clinical phenotypes have become a foundation of biomedical research. Most repositories these data seek to be disease-agnostic therefore lack disease-focused views. The Type 2 Diabetes Knowledge Portal (T2DKP) is public resource datasets genomic annotations dedicated type diabetes (T2D) related traits. Here, we make the T2DKP more accessible prospective users useful existing users. First, evaluate T2DKP's comprehensiveness by comparing its with...
The application of multiple omics technologies in biomedical cohorts has the potential to reveal patient-level disease characteristics and individualized response treatment. However, scale heterogeneous nature multi-modal data makes integration inference a non-trivial task. We developed deep-learning-based framework, multi-omics variational autoencoders (MOVE), integrate such applied it cohort 789 people with newly diagnosed type 2 diabetes deep phenotyping from DIRECT consortium. Using...
To study the effect of calcium supplementation on perimenopausal bone loss, 295 women were randomized into a control group and 2 groups receiving, respectively, 1000 2000 mg elemental calcium/day for period yr. We observed significant decrease in lumbar loss relation to (mean after yr 3.5% vs. 1.3% 0.7% groups, respectively), increase urinary excretion, hydroxyproline/creatinine ratio, serum alkaline phosphatase, osteocalcin, 1,25-dihydroxyvitamin D. The was first year supplementation, but...
Abstract It has been suggested that periodontitis and systemic bone mass might be related. In order to evaluate this possible relationship, we performed an intra‐oral examination measured lumbar mineral density (lumbar BMD) metacarpal cortical thickness (MCT) in 286 female volunteers between 46 55 years of age. addition, the alveolar height was on bite wing radiographs dentate subjects. Of subjects, n =60 (21%) were edentulous. Compared BMD MCT edentulous women not significantly different....
Falls can have devastating consequences for older people. We determined the relationship between likelihood of fall incidents and daily-life behavior. used wearable sensors to assess habitual physical activity gait quality (in terms e.g. stability, variability, smoothness symmetry), their predictive ability time-to-first-and-second-falls. 319 people wore a trunk accelerometer (Dynaport MoveMonitor, McRoberts) during one week. Participants further completed questionnaires performed grip...
ObjectivesThe objectives of this study were to determine the prevalence carriage ESBL-producing Enterobacteriaceae (ESBL-E) in a representative sample general adult Dutch community, identify risk factors and gain understanding epidemiology these resistant strains.
Background Physical function is a crucial factor in the prevention and treatment of health conditions older adults usually measured objectively with physical performance tests and/or activity monitoring. Objective To examine whether 1) (PP) (PA) constitute separate domains function; 2) differentiation PA classes more informative than overall PA. Design Cross-sectional study to explore relationships within among PP measures. Methods In 49 participants (83±7 years; M±SD), performance-based...
Drug-related problems (DRP) following hospital discharge are common among elderly patients using multiple drugs for the treatment of chronic diseases. The aim this study was to investigate occurrence DRP in these a specific tool identification by community pharmacists.An observational involving 340 aged over 60 years at least five prescription and discharged from hospital. assessed means an specifically developed use pharmacists, including semistructured patient interview checklist DRP.In...
We investigated the reliability of physical activity monitoring based on trunk accelerometry in older adults and assessed number measured days required to reliably assess activity. Seventy-nine (mean age 79.1 ± 7.9) wore an accelerometer at lower back during two nonconsecutive weeks. The duration locomotion, lying, sitting, standing shuffling, movement intensity, locomotion bouts transitions standing, median maximum were determined per day. Using data week 2 as reference, intraclass...
Background Studies on neighbourhood characteristics and depression show equivocal results. Aims This large-scale pooled analysis examines whether urbanisation, socioeconomic, physical social are associated with the prevalence severity of depression. Method Cross-sectional design including data from eight Dutch cohort studies ( n = 32 487). Prevalence depression, either DSM-IV diagnosis depressive disorder or scoring for moderately severe symptom scales, continuous scores were analysed....
Depressive symptoms and impaired physical functioning are prevalent among older adults. Supplementation with vitamin D might improve both conditions, particularly in persons low status. The D-Vitaal study primarily aimed to investigate the effect of supplementation on depressive symptoms, functional limitations, performance a high-risk population Secondary aims included examining anxiety cognitive functioning, mobility, handgrip strength, health-related quality life. This was randomized...