A5002843087- Bone health and osteoporosis research
- Bone health and treatments
- Hip and Femur Fractures
- Bone Metabolism and Diseases
- Vitamin D Research Studies
- Bone and Joint Diseases
- Nutrition and Health in Aging
- Parathyroid Disorders and Treatments
- Scoliosis diagnosis and treatment
- Hormonal and reproductive studies
- Cardiovascular Health and Disease Prevention
- Body Composition Measurement Techniques
- Musculoskeletal pain and rehabilitation
- Hip disorders and treatments
- Spine and Intervertebral Disc Pathology
- Medical Imaging and Analysis
- Vitamin C and Antioxidants Research
- Connective tissue disorders research
- Vitamin K Research Studies
- Aortic aneurysm repair treatments
- Spondyloarthritis Studies and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Cerebral Palsy and Movement Disorders
- Muscle metabolism and nutrition
- Bone fractures and treatments
Inserm
2016-2025
Université Claude Bernard Lyon 1
2016-2025
Hôpital Edouard Herriot
2016-2025
Hospices Civils de Lyon
2013-2024
Pathophysiology, Diagnosis and Treatment of Bone Diseases
2018-2023
Mahidol University
2022
Siriraj Hospital
2022
United States Congress
2022
Advisory Board Company (United States)
2021
CHR Verviers
2021
1. Abbreviations used in this paper: GLA, -y-carboxyglutamic acid; OC, osteocalcin; similarly carbOC, carboxylated ucOC, under- also, ucOC%, undercarboxylated
Abstract We previously showed that circulating undercarboxylated osteocalcin (ucOC) is elevated in elderly women and a powerful marker of the subsequent risk hip fracture institutionalized (J Clin Invest 1993; 91:1769). To investigate relationship between bone mass ucOC, we measured mineral density (BMD) with dual-energy x-ray absorptiometry 98 women, 81.4 + 6.0 years old. ucOC was negatively correlated BMD at all sites (r = –0.26 to –0.38, p < 0.001 0.0001), even after exclusion...
Abstract In 796 men, 50-85 years of age, decreased relative skeletal muscle mass index was associated with narrower bones, thinner cortices, and a consequent bending strength (lower section modulus), as well impaired balance an increased risk falls. Introduction: appendicular (ASM) is correlated positively BMC areal BMD (aBMD). elderly low (sarcopenia) difficulties in daily living activities. The aim this study to evaluate if ASM bone size, mechanical properties balance, falls men. Materials...
During recent years, experimental data, case reports, and epidemiological studies have suggested an important role for estradiol in bone metabolism men. In a cohort of 596 men, aged 51–85 yr, we measured mineral density (BMD) the lumbar spine, hip, total body, forearm; serum levels sex steroid hormones [total free testosterone, (17βE2), bioavailable (bio-17βE2), androstenedione, hormone-binding globulin]; markers turnover [serum osteocalcin, alkaline phosphatase, N-terminal extension...
Previous studies have suggested an important role for androgens and estrogens in bone metabolism men. However, their local mode of action has not been clearly established. Osteoprotegerin (OPG) is a secreted decoy receptor that inhibits osteoclast formation activity by neutralizing its cognate ligand. To assess the OPG on men, we conducted study aimed at evaluating serum levels correlation with age, mineral density, biochemical markers turnover, testosterone estradiol 252 aged 19–85 yr....
Abstract The increase in bone fragility after menopause results from reduced periosteal formation and increased endocortical resorption. Women with highest remodeling had greatest loss of mass estimated strength, whereas those low lost less maintained strength. Introduction: Bone the inner (endocortical) surface contributes to fragility, deposition on outer (periosteal) is believed be an adaptive response maintain resistance bending. Materials Methods: To test this hypothesis, changes...
We compared trochanteric soft tissue thickness, femoral aBMD, and the ratio of fall force to strength (i.e., factor risk) in 21 postmenopausal women with incident hip fracture 42 age-matched controls. Reduced low increased were associated risk fracture.The contribution thickness is incompletely understood. A biomechanical approach assessing that compares forces applied during a sideways may by improved incorporating force-attenuating effects tissues.We determined relationship between areal...
Abstract Few studies have investigated bone microarchitecture and biomechanical properties in men. This study assessed vivo both aspects a population of 185 men (aged 71 ± 10 years) with prevalent fragility fractures, compared to controls matched for age, height, weight, from the Structure Aging Men's Bones (STRAMBO) cohort. In this case-control study, areal BMD (aBMD) was measured by DXA, high resolution (HR)-pQCT, finite element (µFE) analysis based on HR-pQCT images distal radius tibia. A...
Increased biochemical bone turnover markers (BTMs) measured in serum are associated with loss, increased fracture risk and poor treatment adherence, but their role clinical practice is presently unclear. The aim of this consensus group report to provide guidance clinicians on how use BTMs patient evaluation postmenopausal osteoporosis, prediction the monitoring efficacy adherence osteoporosis medication. A working scientists specialists was invited by Scientific Advisory Board European...